Literature DB >> 22304911

Hypoxia-inducible factors in physiology and medicine.

Gregg L Semenza1.   

Abstract

Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22304911      PMCID： PMC3437543          DOI： 10.1016/j.cell.2012.01.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  100 in total

1.  An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.

Authors:  Sébastien Bonnet; Evangelos D Michelakis; Christopher J Porter; Miguel A Andrade-Navarro; Bernard Thébaud; Sandra Bonnet; Alois Haromy; Gwyneth Harry; Rohit Moudgil; M Sean McMurtry; E Kenneth Weir; Stephen L Archer
Journal:  Circulation       Date:  2006-05-30       Impact factor: 29.690

2.  Hypoxia requires notch signaling to maintain the undifferentiated cell state.

Authors:  Maria V Gustafsson; Xiaowei Zheng; Teresa Pereira; Katarina Gradin; Shaobo Jin; Johan Lundkvist; Jorge L Ruas; Lorenz Poellinger; Urban Lendahl; Maria Bondesson
Journal:  Dev Cell       Date:  2005-11       Impact factor: 12.270

3.  Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha.

Authors:  A Y Yu; L A Shimoda; N V Iyer; D L Huso; X Sun; R McWilliams; T Beaty; J S Sham; C M Wiener; J T Sylvester; G L Semenza
Journal:  J Clin Invest       Date:  1999-03       Impact factor: 14.808

4.  Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease.

Authors:  Jon R Resar; Ariel Roguin; Jeffery Voner; Khurram Nasir; Thomas A Hennebry; Julie M Miller; Roxann Ingersoll; Laura M Kasch; Gregg L Semenza
Journal:  Chest       Date:  2005-08       Impact factor: 9.410

5.  The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.

Authors:  H Tian; R E Hammer; A M Matsumoto; D W Russell; S L McKnight
Journal:  Genes Dev       Date:  1998-11-01       Impact factor: 11.361

6.  HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

Authors:  Ioanna Papandreou; Rob A Cairns; Lucrezia Fontana; Ai Lin Lim; Nicholas C Denko
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

7.  HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Authors:  Jung-whan Kim; Irina Tchernyshyov; Gregg L Semenza; Chi V Dang
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

8.  Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung.

Authors:  A Y Yu; M G Frid; L A Shimoda; C M Wiener; K Stenmark; G L Semenza
Journal:  Am J Physiol       Date:  1998-10

9.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche.

Authors:  Rosandra N Kaplan; Rebecca D Riba; Stergios Zacharoulis; Anna H Bramley; Loïc Vincent; Carla Costa; Daniel D MacDonald; David K Jin; Koji Shido; Scott A Kerns; Zhenping Zhu; Daniel Hicklin; Yan Wu; Jeffrey L Port; Nasser Altorki; Elisa R Port; Davide Ruggero; Sergey V Shmelkov; Kristian K Jensen; Shahin Rafii; David Lyden
Journal:  Nature       Date:  2005-12-08       Impact factor: 49.962

10.  Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology.

Authors:  Thomas G Smith; Jerome T Brooks; George M Balanos; Terence R Lappin; D Mark Layton; Dawn L Leedham; Chun Liu; Patrick H Maxwell; Mary F McMullin; Christopher J McNamara; Melanie J Percy; Christopher W Pugh; Peter J Ratcliffe; Nick P Talbot; Marilyn Treacy; Peter A Robbins
Journal:  PLoS Med       Date:  2006-07       Impact factor: 11.069
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  1128 in total

1.  Loss of endothelial-ARNT in adult mice contributes to dampened circulating proangiogenic cells and delayed wound healing.

Authors:  Yu Han; Jiayi Tao; Alla Gomer; Diana L Ramirez-Bergeron
Journal:  Vasc Med       Date:  2014-11-14       Impact factor: 3.239

2.  Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.

Authors:  Naoharu Takano; Ying-Jie Peng; Ganesh K Kumar; Weibo Luo; Hongxia Hu; Larissa A Shimoda; Makoto Suematsu; Nanduri R Prabhakar; Gregg L Semenza
Journal:  Biochem J       Date:  2014-03-01       Impact factor: 3.857

Review 3.  Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration.

Authors:  Marten Szibor; Jochen Pöling; Henning Warnecke; Thomas Kubin; Thomas Braun
Journal:  Cell Mol Life Sci       Date:  2013-12-10       Impact factor: 9.261

4.  Hypoxia induces downregulation of soluble guanylyl cyclase β1 by miR-34c-5p.

Authors:  Xiaojian Xu; Shumin Wang; Juan Liu; Dou Dou; Limei Liu; Zhengju Chen; Liping Ye; Huixia Liu; Qiong He; J Usha Raj; Yuansheng Gao
Journal:  J Cell Sci       Date:  2012-10-04       Impact factor: 5.285

Review 5.  An arranged marriage for precision medicine: hypoxia and genomic assays in localized prostate cancer radiotherapy.

Authors:  R G Bristow; A Berlin; A Dal Pra
Journal:  Br J Radiol       Date:  2014-02-03       Impact factor: 3.039

6.  Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response.

Authors:  R Lall; S Ganapathy; M Yang; S Xiao; T Xu; H Su; M Shadfan; J M Asara; C S Ha; I Ben-Sahra; B D Manning; J B Little; Z-M Yuan
Journal:  Cell Death Differ       Date:  2014-02-28       Impact factor: 15.828

Review 7.  New Insights into the Nuclear Imaging Phenotypes of Cluster 1 Pheochromocytoma and Paraganglioma.

Authors:  David Taïeb; Karel Pacak
Journal:  Trends Endocrinol Metab       Date:  2017-08-31       Impact factor: 12.015

8.  HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition.

Authors:  Mari Ekman; Bengt Uvelius; Sebastian Albinsson; Karl Swärd
Journal:  Lab Invest       Date:  2014-03-03       Impact factor: 5.662

Review 9.  MYC, Metabolism, and Cancer.

Authors:  Zachary E Stine; Zandra E Walton; Brian J Altman; Annie L Hsieh; Chi V Dang
Journal:  Cancer Discov       Date:  2015-09-17       Impact factor: 39.397

Review 10.  Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas.

Authors:  Görkem Eskiizmir
Journal:  Turk Arch Otorhinolaryngol       Date:  2015-09-01
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