Literature DB >> 32617906

Practical implications of the 2019 Nobel Prize in Physiology or Medicine: from molecular adaptation to hypoxia to novel anti-anemic drugs in the clinic.

Fabiana Busti1, Giacomo Marchi2, Alice Vianello2, Domenico Girelli2.   

Abstract

The 2019 Nobel Prize for Medicine or Physiology was assigned to three prestigious physician-scientists, Gregg L. Semenza, William G. Kaelin, and Peter J. Ratcliffe, who clarified the molecular mechanisms of hypoxia adaptation. This viewpoint traces their fundamental findings, which have paved the way for the development of innovative drugs for a wide range of common diseases, including cancer and anemia.

Entities:  

Keywords:  Erythropoiesis; HIF; Hypoxia; Iron homeostasis; Nobel Prize; PHD inhibitors

Mesh：

Year:  2020        PMID： 32617906     DOI： 10.1007/s11739-020-02417-w

Source DB:  PubMed          Journal:  Intern Emerg Med        ISSN： 1828-0447            Impact factor:   3.397


  19 in total

1.  A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

Authors:  G L Semenza; G L Wang
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

2.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors:  P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal:  Nature       Date:  1999-05-20       Impact factor: 49.962

3.  Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors:  P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

4.  HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.

Authors:  M Ivan; K Kondo; H Yang; W Kim; J Valiando; M Ohh; A Salic; J M Asara; W S Lane; W G Kaelin
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

5.  Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.

Authors:  Andrew J Schwartz; Nupur K Das; Sadeesh K Ramakrishnan; Chesta Jain; Mladen T Jurkovic; Jun Wu; Elizabeta Nemeth; Samira Lakhal-Littleton; Justin A Colacino; Yatrik M Shah
Journal:  J Clin Invest       Date:  2018-12-10       Impact factor: 14.808

Review 6.  Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis.

Authors:  Gregg L Semenza
Journal:  Blood       Date:  2009-06-03       Impact factor: 22.113

Review 7.  Oxygen Sensing and Homeostasis.

Authors:  Nanduri R Prabhakar; Gregg L Semenza
Journal:  Physiology (Bethesda)       Date:  2015-09

Review 8.  Hepcidin in the diagnosis of iron disorders.

Authors:  Domenico Girelli; Elizabeta Nemeth; Dorine W Swinkels
Journal:  Blood       Date:  2016-04-04       Impact factor: 22.113

Review 9.  New insights into the links between hypoxia and iron homeostasis.

Authors:  Cyril Renassia; Carole Peyssonnaux
Journal:  Curr Opin Hematol       Date:  2019-05       Impact factor: 3.284

10.  NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice.

Authors:  Antonella Nai; Maria Rosa Lidonnici; Giorgia Federico; Mariateresa Pettinato; Violante Olivari; Federica Carrillo; Simonetta Geninatti Crich; Giuliana Ferrari; Clara Camaschella; Laura Silvestri; Francesca Carlomagno
Journal:  Haematologica       Date:  2021-03-01       Impact factor: 9.941
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