Literature DB >> 26324270

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.

Ranae M Ranade1, Zhongsheng Zhang2, J Robert Gillespie1, Sayaka Shibata2, Christophe L M J Verlinde2, Wim G J Hol2, Erkang Fan2, Frederick S Buckner3.   

Abstract

The methionyl-tRNA synthetase (MetRS) is a novel drug target for the protozoan pathogen Giardia intestinalis. This protist contains a single MetRS that is distinct from the human cytoplasmic MetRS. A panel of MetRS inhibitors was tested against recombinant Giardia MetRS, Giardia trophozoites, and mammalian cell lines. The best compounds inhibited trophozoite growth at 500 nM (metronidazole did so at ∼5,000 nM) and had low cytotoxicity against mammalian cells, indicating excellent potential for further development as anti-Giardia drugs.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26324270      PMCID： PMC4604383          DOI： 10.1128/AAC.01573-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements.

Authors:  Catherine Z Chen; Liudmila Kulakova; Noel Southall; Juan J Marugan; Andrey Galkin; Christopher P Austin; Osnat Herzberg; Wei Zheng
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

2.  Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.

Authors:  Sayaka Shibata; J Robert Gillespie; Angela M Kelley; Alberto J Napuli; Zhongsheng Zhang; Kuzma V Kovzun; Ranae M Pefley; Jocelyn Lam; Frank H Zucker; Wesley C Van Voorhis; Ethan A Merritt; Wim G J Hol; Christophe L M J Verlinde; Erkang Fan; Frederick S Buckner
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

3.  Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.

Authors:  Christopher Mehlin; Erica Boni; Frederick S Buckner; Linnea Engel; Tiffany Feist; Michael H Gelb; Lutfiyah Haji; David Kim; Colleen Liu; Natascha Mueller; Peter J Myler; J T Reddy; Joshua N Sampson; E Subramanian; Wesley C Van Voorhis; Elizabeth Worthey; Frank Zucker; Wim G J Hol
Journal:  Mol Biochem Parasitol       Date:  2006-04-18       Impact factor: 1.759

4.  Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile.

Authors:  D B Keister
Journal:  Trans R Soc Trop Med Hyg       Date:  1983       Impact factor: 2.184

5.  Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Authors:  Richard L Jarvest; John M Berge; Valerie Berry; Helen F Boyd; Murray J Brown; John S Elder; Andrew K Forrest; Andrew P Fosberry; Daniel R Gentry; Martin J Hibbs; Deborah D Jaworski; Peter J O'Hanlon; Andrew J Pope; Stephen Rittenhouse; Robert J Sheppard; Courtney Slater-Radosti; Angela Worby
Journal:  J Med Chem       Date:  2002-05-09       Impact factor: 7.446

6.  Dual targeting of aminoacyl-tRNA synthetases to the apicoplast and cytosol in Plasmodium falciparum.

Authors:  Katherine E Jackson; James S Pham; Michelle Kwek; Nilushi S De Silva; Stacey M Allen; Christopher D Goodman; Geoffrey I McFadden; Lluis Ribas de Pouplana; Stuart A Ralph
Journal:  Int J Parasitol       Date:  2011-12-24       Impact factor: 3.981

7.  Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection.

Authors:  Cho Yeow Koh; Jessica E Kim; Sayaka Shibata; Ranae M Ranade; Mingyan Yu; Jiyun Liu; J Robert Gillespie; Frederick S Buckner; Christophe L M J Verlinde; Erkang Fan; Wim G J Hol
Journal:  Structure       Date:  2012-08-16       Impact factor: 5.006

8.  Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.

Authors:  Laura Pedró-Rosa; Frederick S Buckner; Ranae M Ranade; Christina Eberhart; Franck Madoux; J Robert Gillespie; Cho Yeow Koh; Steven Brown; Jacqueline Lohse; Christophe L M Verlinde; Erkang Fan; Thomas Bannister; Louis Scampavia; Wim G J Hol; Timothy Spicer; Peter Hodder
Journal:  J Biomol Screen       Date:  2014-08-27

9.  An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Authors:  Fernando L Rock; Weimin Mao; Anya Yaremchuk; Mikhail Tukalo; Thibaut Crépin; Huchen Zhou; Yong-Kang Zhang; Vincent Hernandez; Tsutomu Akama; Stephen J Baker; Jacob J Plattner; Lucy Shapiro; Susan A Martinis; Stephen J Benkovic; Stephen Cusack; M R K Alley
Journal:  Science       Date:  2007-06-22       Impact factor: 47.728

10.  GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis.

Authors:  Cristina Aurrecoechea; John Brestelli; Brian P Brunk; Jane M Carlton; Jennifer Dommer; Steve Fischer; Bindu Gajria; Xin Gao; Alan Gingle; Greg Grant; Omar S Harb; Mark Heiges; Frank Innamorato; John Iodice; Jessica C Kissinger; Eileen Kraemer; Wei Li; John A Miller; Hilary G Morrison; Vishal Nayak; Cary Pennington; Deborah F Pinney; David S Roos; Chris Ross; Christian J Stoeckert; Steven Sullivan; Charles Treatman; Haiming Wang
Journal:  Nucleic Acids Res       Date:  2008-09-29       Impact factor: 16.971
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  9 in total

1.  Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.

Authors:  Samantha A Michaels; Han-Wei Shih; Bailin Zhang; Edelmar D Navaluna; Zhongsheng Zhang; Ranae M Ranade; J Robert Gillespie; Ethan A Merritt; Erkang Fan; Frederick S Buckner; Alexander R Paredez; Kayode K Ojo
Journal:  J Antimicrob Chemother       Date:  2020-05-01       Impact factor: 5.790

2.  Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.

Authors:  Omeed Faghih; Zhongsheng Zhang; Ranae M Ranade; J Robert Gillespie; Sharon A Creason; Wenlin Huang; Sayaka Shibata; Ximena Barros-Álvarez; Christophe L M J Verlinde; Wim G J Hol; Erkang Fan; Frederick S Buckner
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

3.  Dual-targeted hit identification using pharmacophore screening.

Authors:  Galyna P Volynets; Sergiy A Starosyla; Mariia Yu Rybak; Volodymyr G Bdzhola; Oksana P Kovalenko; Vasyl S Vdovin; Sergiy M Yarmoluk; Michail A Tukalo
Journal:  J Comput Aided Mol Des       Date:  2019-11-06       Impact factor: 3.686

4.  Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

Authors:  Wenlin Huang; Zhongsheng Zhang; Ximena Barros-Álvarez; Cho Yeow Koh; Ranae M Ranade; J Robert Gillespie; Sharon A Creason; Sayaka Shibata; Christophe L M J Verlinde; Wim G J Hol; Frederick S Buckner; Erkang Fan
Journal:  Eur J Med Chem       Date:  2016-10-14       Impact factor: 6.514

5.  From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.

Authors:  William G Devine; Rosario Diaz-Gonzalez; Gloria Ceballos-Perez; Domingo Rojas; Takashi Satoh; Westley Tear; Ranae M Ranade; Ximena Barros-Álvarez; Wim G J Hol; Frederick S Buckner; Miguel Navarro; Michael P Pollastri
Journal:  ACS Infect Dis       Date:  2017-02-08       Impact factor: 5.084

6.  Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N'-thiazol-2-yl-hydrazines.

Authors:  Oksana P Kovalenko; Galyna P Volynets; Mariia Yu Rybak; Sergiy A Starosyla; Olga I Gudzera; Sergiy S Lukashov; Volodymyr G Bdzhola; Sergiy M Yarmoluk; Helena I Boshoff; Michael A Tukalo
Journal:  Medchemcomm       Date:  2019-11-28       Impact factor: 3.597

7.  Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Authors:  Kayode K Ojo; Ranae M Ranade; Zhongsheng Zhang; David M Dranow; Janette B Myers; Ryan Choi; Steve Nakazawa Hewitt; Thomas E Edwards; Douglas R Davies; Donald Lorimer; Stephen M Boyle; Lynn K Barrett; Frederick S Buckner; Erkang Fan; Wesley C Van Voorhis
Journal:  PLoS One       Date:  2016-08-08       Impact factor: 3.240

8.  5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.

Authors:  Zhongsheng Zhang; Cho Yeow Koh; Ranae M Ranade; Sayaka Shibata; J Robert Gillespie; Matthew A Hulverson; Wenlin Huang; Jasmine Nguyen; Nagendar Pendem; Michael H Gelb; Christophe L M J Verlinde; Wim G J Hol; Frederick S Buckner; Erkang Fan
Journal:  ACS Infect Dis       Date:  2016-04-11       Impact factor: 5.084

9.  Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum.

Authors:  Kelly M Hennessey; Ilse C Rogiers; Han-Wei Shih; Matthew A Hulverson; Ryan Choi; Molly C McCloskey; Grant R Whitman; Lynn K Barrett; Ethan A Merritt; Alexander R Paredez; Kayode K Ojo
Journal:  PLoS Negl Trop Dis       Date:  2018-08-06
  9 in total

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