| Literature DB >> 11985462 |
Richard L Jarvest, John M Berge, Valerie Berry, Helen F Boyd, Murray J Brown, John S Elder, Andrew K Forrest, Andrew P Fosberry, Daniel R Gentry, Martin J Hibbs, Deborah D Jaworski, Peter J O'Hanlon, Andrew J Pope, Stephen Rittenhouse, Robert J Sheppard, Courtney Slater-Radosti, Angela Worby.
Abstract
Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized compounds show excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics. Compound 11 demonstrated in vivo efficacy in an S. aureus rat abscess infection model.Entities:
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Year: 2002 PMID： 11985462 DOI： 10.1021/jm025502x
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446