| Literature DB >> 26321784 |
Shijun Sung1, James Garritano2, Neha Bajwa2, Sophie Deng3, Jean-Pierre Hubschman3, Warren S Grundfest4, Zachary D Taylor5.
Abstract
This paper presents a novel THz optical design that allows the acquisition of THz reflectivity maps of in vivo cornea without the need for a field flattening window and preliminary imaging results of in vivo rabbit cornea. The system's intended use is to sense small changes in corneal tissue water content (CTWC) that can be precursors for a host of diseases and pathologies. Unique beam optics allows the scanning of a curved surface at normal incidence while keeping the source detector and target stationary. Basic system design principles are discussed and image sets of spherical calibration targets and corneal phantom models are presented. The presented design will enable, for the first time, non-contact THz imaging of animal and human cornea.Entities:
Keywords: THz medical imaging; optical design; quasioptics
Year: 2015 PMID: 26321784 PMCID: PMC4551114 DOI: 10.1117/12.2086866
Source DB: PubMed Journal: Proc SPIE Int Soc Opt Eng ISSN: 0277-786X