Literature DB >> 26321784

Preliminary results of non-contact THz imaging of cornea.

Shijun Sung1, James Garritano2, Neha Bajwa2, Sophie Deng3, Jean-Pierre Hubschman3, Warren S Grundfest4, Zachary D Taylor5.   

Abstract

This paper presents a novel THz optical design that allows the acquisition of THz reflectivity maps of in vivo cornea without the need for a field flattening window and preliminary imaging results of in vivo rabbit cornea. The system's intended use is to sense small changes in corneal tissue water content (CTWC) that can be precursors for a host of diseases and pathologies. Unique beam optics allows the scanning of a curved surface at normal incidence while keeping the source detector and target stationary. Basic system design principles are discussed and image sets of spherical calibration targets and corneal phantom models are presented. The presented design will enable, for the first time, non-contact THz imaging of animal and human cornea.

Entities:  

Keywords:  THz medical imaging; optical design; quasioptics

Year:  2015        PMID: 26321784      PMCID: PMC4551114          DOI: 10.1117/12.2086866

Source DB:  PubMed          Journal:  Proc SPIE Int Soc Opt Eng        ISSN: 0277-786X


  14 in total

1.  Terahertz sensing in corneal tissues.

Authors:  David B Bennett; Zachary D Taylor; Pria Tewari; Rahul S Singh; Martin O Culjat; Warren S Grundfest; Daniel J Sassoon; R Duncan Johnson; Jean-Pierre Hubschman; Elliott R Brown
Journal:  J Biomed Opt       Date:  2011-05       Impact factor: 3.170

2.  Repeatability and reproducibility of central corneal thickness measurement with Pentacam, Orbscan, and ultrasound.

Authors:  Birgit Lackner; Gerald Schmidinger; Stefan Pieh; Martin A Funovics; Christian Skorpik
Journal:  Optom Vis Sci       Date:  2005-10       Impact factor: 1.973

3.  Time-domain transillumination of biological tissues with terahertz pulses.

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Journal:  Opt Lett       Date:  2000-02-15       Impact factor: 3.776

4.  T-ray computed tomography.

Authors:  Bradley Ferguson; Shaohong Wang; Doug Gray; Derek Abbot; X-C Zhang
Journal:  Opt Lett       Date:  2002-08-01       Impact factor: 3.776

5.  Terahertz dark-field imaging of biomedical tissue.

Authors:  T Löffler; T Bauer; K Siebert; H Roskos; A Fitzgerald; S Czasch
Journal:  Opt Express       Date:  2001-12-03       Impact factor: 3.894

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Authors:  Y S Rabinowitz
Journal:  Surv Ophthalmol       Date:  1998 Jan-Feb       Impact factor: 6.048

Review 7.  Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach.

Authors:  M J Doughty; M L Zaman
Journal:  Surv Ophthalmol       Date:  2000 Mar-Apr       Impact factor: 6.048

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Journal:  Surv Ophthalmol       Date:  1993 Sep-Oct       Impact factor: 6.048

9.  THz Medical Imaging: in vivo Hydration Sensing.

Authors:  Zachary D Taylor; Rahul S Singh; David B Bennett; Priyamvada Tewari; Colin P Kealey; Neha Bajwa; Martin O Culjat; Alexander Stojadinovic; Hua Lee; Jean-Pierre Hubschman; Elliott R Brown; Warren S Grundfest
Journal:  IEEE Trans Terahertz Sci Technol       Date:  2011-09       Impact factor: 3.274

10.  Central corneal thickness: z-ring corneal confocal microscopy versus ultrasound pachymetry.

Authors:  Erica Brugin; Alessandra Ghirlando; Catia Gambato; Edoardo Midena
Journal:  Cornea       Date:  2007-04       Impact factor: 2.651

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  3 in total

1.  Corneal hydration assessment indicator based on terahertz time domain spectroscopy.

Authors:  Jiali Yao; Jiaonan Ma; Jiehui Zhao; Pengfei Qi; Mengdi Li; Lie Lin; Lu Sun; Xiaolei Wang; Weiwei Liu; Yan Wang
Journal:  Biomed Opt Express       Date:  2020-03-18       Impact factor: 3.732

2.  Non-contact terahertz spectroscopic measurement of the intraocular pressure through corneal hydration mapping.

Authors:  Andrew Chen; Arjun Virk; Zachery Harris; Azin Abazari; Robert Honkanen; M Hassan Arbab
Journal:  Biomed Opt Express       Date:  2021-05-17       Impact factor: 3.732

3.  Safety profiles of terahertz scanning in ophthalmology.

Authors:  Yu-Chi Liu; Lin Ke; Steve Wu Qing Yang; Zhang Nan; Ericia Pei Wen Teo; Nyein Chan Lwin; Molly Tzu-Yu Lin; Isabelle Xin Yu Lee; Anita Sook-Yee Chan; Leopold Schmetterer; Jodhbir S Mehta
Journal:  Sci Rep       Date:  2021-01-28       Impact factor: 4.379

  3 in total

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