Literature DB >> 26321604

Syntheses and studies of new forms of N-sulfonyloxy β-lactams as potential antibacterial agents and β-lactamase inhibitors.

Serena Carosso1, Marvin J Miller2.   

Abstract

The synthesis of a small library of N-sulfonyloxy-2-azetidinones is reported and the preliminary results of the investigation of the biological activity of these molecules are discussed. These new multi-electrophilic β-lactams ('electrophilic bombs') display unexpected selectivity in their antibacterial activity and β-lactamase inhibitory activity.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  N-Sulfonyloxy β-lactam; Oxidatative lactamization; β-Lactamase inhibitors

Mesh：

Substances：

Year:  2015        PMID： 26321604      PMCID： PMC4562877          DOI： 10.1016/j.bmc.2015.08.005

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

1.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Authors:  Hartmuth C. Kolb; M. G. Finn; K. Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2001-06-01       Impact factor: 15.336

Review 2.  Click chemistry: 1,2,3-triazoles as pharmacophores.

Authors:  Sandip G Agalave; Suleman R Maujan; Vandana S Pore
Journal:  Chem Asian J       Date:  2011-08-29

Review 3.  Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria.

Authors:  Michael W Crowder; James Spencer; Alejandro J Vila
Journal:  Acc Chem Res       Date:  2006-10       Impact factor: 22.384

Review 4.  Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.

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Journal:  Clin Infect Dis       Date:  1997-01       Impact factor: 9.079

5.  beta-Lactamase inhibitors derived from N-tosyloxy-beta-lactams.

Authors:  M Teng; M J Miller; T I Nicas; J Grissom-Arnold; R D Cooper
Journal:  Bioorg Med Chem       Date:  1993-08       Impact factor: 3.641

6.  Monocyclic beta-lactam antibiotics produced by bacteria.

Authors:  R B Sykes; C M Cimarusti; D P Bonner; K Bush; D M Floyd; N H Georgopapadakou; W M Koster; W C Liu; W L Parker; P A Principe; M L Rathnum; W A Slusarchyk; W H Trejo; J S Wells
Journal:  Nature       Date:  1981-06-11       Impact factor: 49.962

7.  A quick method for the determination of inhibition constants.

Authors:  S G Waley
Journal:  Biochem J       Date:  1982-09-01       Impact factor: 3.857

8.  Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams.

Authors:  L Mourey; L P Kotra; J Bellettini; A Bulychev; M O'Brien; M J Miller; S Mobashery; J P Samama
Journal:  J Biol Chem       Date:  1999-09-03       Impact factor: 5.157

Review 9.  The growing impact of click chemistry on drug discovery.

Authors:  Hartmuth C Kolb; K Barry Sharpless
Journal:  Drug Discov Today       Date:  2003-12-15       Impact factor: 7.851

10.  Sulfazecin and isosulfazecin, novel beta-lactam antibiotics of bacterial origin.

Authors:  A Imada; K Kitano; K Kintaka; M Muroi; M Asai
Journal:  Nature       Date:  1981-02-12       Impact factor: 49.962
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