Literature DB >> 8081845

beta-Lactamase inhibitors derived from N-tosyloxy-beta-lactams.

M Teng1, M J Miller, T I Nicas, J Grissom-Arnold, R D Cooper.   

Abstract

Electrophilic N-tosyloxy-beta-lactams, N-tosyloxy-4-phenyl-2-azetidinone (2b) and N-tosyloxy-3-(S)-phthalimido-4-(S)-2-azetidinone (2c), are described. These agents are novel potent beta-lactamase inhibitors.

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Year:  1993        PMID： 8081845     DOI： 10.1016/s0968-0896(00)82113-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  Syntheses and studies of new forms of N-sulfonyloxy β-lactams as potential antibacterial agents and β-lactamase inhibitors.

Authors:  Serena Carosso; Marvin J Miller
Journal:  Bioorg Med Chem       Date:  2015-08-14       Impact factor: 3.641

Review 2.  Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis.

Authors:  Patrick Rabe; Jos J A G Kamps; Christopher J Schofield; Christopher T Lohans
Journal:  Nat Prod Rep       Date:  2018-08-15       Impact factor: 13.423
  2 in total

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