Renato de Lima Azambuja1, Layla Salomao Eulalio da Costa Santos Azambuja1, Cláudia Costa1, Rogério Rufino2,3. 1. Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, CEP 20551-030, Brazil. 2. Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, CEP 20551-030, Brazil. rrufino.uerj@gmail.com. 3. Pulmonology Department, Hospital Universitário Pedro Ernesto, Avenida 28 de Setembro, 77, Rio de Janeiro, RJ, CEP 20551-030, Brazil. rrufino.uerj@gmail.com.
Abstract
PURPOSE: The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. METHODS: We conducted a cross-sectional study with asthma with different body mass indices (BMI); the patients were classified as eutrophic, overweight, or obese. We assessed disease control using the GINA consensus, and the levels of adiponectin, C-reactive protein (CRP) and interleukin 33 (IL-33) in each of the patients. RESULTS: We evaluated 75 of the 96 patients eligible for the study, including 25 in each BMI group. The CRP levels were significantly higher in the obese patients compared with both the eutrophic (p = 0.01) and the overweight (p = 0.03) patients. The mean adiponectin level was 21.82 ± 9.93 mg/L for the eutrophic asthmatics, which is a level that was significantly higher than in the overweight (15.31 ± 6.27 mg/L, p = 0.0140) and the obese (16.69 ± 11.45 mg/L, p = 0.0287) patients. The patients with higher adiponectin levels exhibited smaller FEV1 (p = 0.02) and lower FVC (p = 0.003). The IL-33 levels were not different between the groups. CONCLUSIONS: Adiponectin does not protect against the development of inflammation in the setting of asthma and may in fact exacerbate the disease via its anti-TH1 inflammatory effects, allowing for increased TH2 differentiation and a more severe allergic response.
PURPOSE: The relationship between asthma and obesity is well established, although the pathophysiological mechanisms linking both diseases remain unknown. Adiponectin is a hormone secreted by adipose cells, plays a role in the modulation of inflammation and may be the key linking these two types of inflammation. METHODS: We conducted a cross-sectional study with asthma with different body mass indices (BMI); the patients were classified as eutrophic, overweight, or obese. We assessed disease control using the GINA consensus, and the levels of adiponectin, C-reactive protein (CRP) and interleukin 33 (IL-33) in each of the patients. RESULTS: We evaluated 75 of the 96 patients eligible for the study, including 25 in each BMI group. The CRP levels were significantly higher in the obesepatients compared with both the eutrophic (p = 0.01) and the overweight (p = 0.03) patients. The mean adiponectin level was 21.82 ± 9.93 mg/L for the eutrophic asthmatics, which is a level that was significantly higher than in the overweight (15.31 ± 6.27 mg/L, p = 0.0140) and the obese (16.69 ± 11.45 mg/L, p = 0.0287) patients. The patients with higher adiponectin levels exhibited smaller FEV1 (p = 0.02) and lower FVC (p = 0.003). The IL-33 levels were not different between the groups. CONCLUSIONS:Adiponectin does not protect against the development of inflammation in the setting of asthma and may in fact exacerbate the disease via its anti-TH1 inflammatory effects, allowing for increased TH2 differentiation and a more severe allergic response.
Authors: Akshay Sood; Clifford Qualls; Mark Schuyler; Bharat Thyagarajan; Michael W Steffes; Lewis J Smith; David R Jacobs Journal: Am J Respir Crit Care Med Date: 2012-04-06 Impact factor: 21.405
Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: Meghan C Wulster-Radcliffe; Kolapo M Ajuwon; Jiazhen Wang; John A Christian; Michael E Spurlock Journal: Biochem Biophys Res Commun Date: 2004-04-09 Impact factor: 3.575
Authors: Akshay Sood; Elizabeth Dominic; Clifford Qualls; Michael W Steffes; Bharat Thyagarajan; Lewis J Smith; Cora E Lewis; David R Jacobs Journal: Front Pharmacol Date: 2011-10-05 Impact factor: 5.810
Authors: Julie V Philley; Anbarasu Kannan; David E Griffith; Megan S Devine; Jeana L Benwill; Richard J Wallace; Barbara A Brown-Elliott; Foram Thakkar; Varsha Taskar; James G Fox; Ammar Alqaid; Hernaina Bains; Sudeep Gupta; Santanu Dasgupta Journal: Oncotarget Date: 2017-03-14
Authors: Aleksandra Rył; Aleksandra Szylińska; Alina Jurewicz; Andrzej Bohatyrewicz; Tomasz Miazgowski; Iwona Rotter Journal: Int J Environ Res Public Health Date: 2019-12-22 Impact factor: 3.390