Literature DB >> 27401625

Biomarkers in Severe Asthma.

Xiao Chloe Wan1, Prescott G Woodruff2.   

Abstract

Biomarkers have been critical for studies of disease pathogenesis and the development of new therapies in severe asthma. In particular, biomarkers of type 2 inflammation have proven valuable for endotyping and targeting new biological agents. Because of these successes in understanding and marking type 2 inflammation, lack of knowledge regarding non-type 2 inflammatory mechanisms in asthma will soon be the major obstacle to the development of new treatments and management strategies in severe asthma. Biomarkers can play a role in these investigations as well by providing insight into the underlying biology in human studies of patients with severe asthma.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Biomarker; Endotype; Eosinophil; Exhaled nitric oxide; Periostin; Severe asthma

Mesh：

Substances：

Year:  2016        PMID： 27401625      PMCID： PMC6057475          DOI： 10.1016/j.iac.2016.03.004

Source DB:  PubMed          Journal:  Immunol Allergy Clin North Am        ISSN： 0889-8561            Impact factor:   3.479


  87 in total

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Journal:  Am J Respir Crit Care Med       Date:  2013-12-01       Impact factor: 21.405

4.  Effects of steroid therapy on inflammatory cell subtypes in asthma.

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5.  Sputum in severe exacerbations of asthma: kinetics of inflammatory indices after prednisone treatment.

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Journal:  Am J Respir Crit Care Med       Date:  1997-05       Impact factor: 21.405

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Journal:  Am J Respir Crit Care Med       Date:  1996-08       Impact factor: 21.405

7.  Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids.

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8.  Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.

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2.  miR-144-3p Is a Biomarker Related to Severe Corticosteroid-Dependent Asthma.

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Review 4.  Biomarkers for Severe Asthma: Lessons From Longitudinal Cohort Studies.

Authors:  Youngsoo Lee; Quang Luu Quoc; Hae Sim Park
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Review 5.  A review on the effect of COVID-19 in type 2 asthma and its management.

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Review 6.  Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies.

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Review 7.  Biomarkers in Different Asthma Phenotypes.

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8.  Using biomarkers to adjust corticosteroid dose in patients with severe asthma.

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9.  Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma.

Authors:  Mahmood Yaseen Hachim; Noha Mousaad Elemam; Rakhee K Ramakrishnan; Laila Salameh; Ronald Olivenstein; Ibrahim Yaseen Hachim; Thenmozhi Venkatachalam; Bassam Mahboub; Saba Al Heialy; Rabih Halwani; Qutayba Hamid; Rifat Hamoudi
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Review 10.  An update on the diagnostic biomarkers for asthma.

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