Literature DB >> 26312245

Intestinal microbial metabolism of phosphatidylcholine: a novel insight in the cardiovascular risk scenario.

Enzo Ierardi1, Claudia Sorrentino1, Mariabeatrice Principi1, Floriana Giorgio1, Giuseppe Losurdo1, Alfredo Di Leo1.   

Abstract

Intestinal microbiota is a "dynamic organ" influencing host metabolism, nutrition, physiology and immune system. Among its several interactions, the role of a phosphatidylcholine metabolite derived by gut flora activity, i.e., trimethylamine-N-oxide (TMAO), allows perceiving a novel insight in the cardiovascular risk scenario, being a strong predictor of this condition. Based on current reports, including the paper of Tang et al., we describe here: the possible role of intestinal microbiota in cardiovascular risk as well as potential interventions to reduce gut flora TMAO production by diet, probiotics and antibiotics. Finally, we highlight the possibility of evaluating, monitoring and modulating TMAO in order to use its serum levels as a marker of cardiovascular risk in the next future, when the need of controlled studies on large series will be satisfied.

Entities:  

Keywords:  Intestinal microbiota; antibiotics; cardiovascular risk; choline; probiotics; trimethylamine-N-oxide (TMAO)

Year:  2015        PMID： 26312245      PMCID： PMC4526767          DOI： 10.3978/j.issn.2304-3881.2015.02.01

Source DB:  PubMed          Journal:  Hepatobiliary Surg Nutr        ISSN： 2304-3881            Impact factor:   7.293


  19 in total

Review 1.  The multifaceted role of the intestinal microbiota in colon cancer.

Authors:  Thergiory Irrazábal; Antoaneta Belcheva; Stephen E Girardin; Alberto Martin; Dana J Philpott
Journal:  Mol Cell       Date:  2014-04-24       Impact factor: 17.970

2.  Trimethylaminuria: causes and diagnosis of a socially distressing condition.

Authors:  Richard J Mackay; Christopher J McEntyre; Caroline Henderson; Michael Lever; Peter M George
Journal:  Clin Biochem Rev       Date:  2011-02

Review 3.  The impact of gut microbes in allergic diseases.

Authors:  Shannon L Russell; Brett B Finlay
Journal:  Curr Opin Gastroenterol       Date:  2012-11       Impact factor: 3.287

4.  Transmission of atherosclerosis susceptibility with gut microbial transplantation.

Authors:  Jill C Gregory; Jennifer A Buffa; Elin Org; Zeneng Wang; Bruce S Levison; Weifei Zhu; Matthew A Wagner; Brian J Bennett; Lin Li; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen
Journal:  J Biol Chem       Date:  2014-12-30       Impact factor: 5.157

Review 5.  Gut microbiota and metabolic syndrome.

Authors:  Davide Festi; Ramona Schiumerini; Leonardo Henry Eusebi; Giovanni Marasco; Martina Taddia; Antonio Colecchia
Journal:  World J Gastroenterol       Date:  2014-11-21       Impact factor: 5.742

Review 6.  The role of the gut and microbes in the pathogenesis of spondyloarthritis.

Authors:  Mark Asquith; Dirk Elewaut; Phoebe Lin; James T Rosenbaum
Journal:  Best Pract Res Clin Rheumatol       Date:  2014-11-15       Impact factor: 4.098

7.  Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

Authors:  W H Wilson Tang; Zeneng Wang; Bruce S Levison; Robert A Koeth; Earl B Britt; Xiaoming Fu; Yuping Wu; Stanley L Hazen
Journal:  N Engl J Med       Date:  2013-04-25       Impact factor: 91.245

8.  Endothelial function and cardiovascular risk in active inflammatory bowel diseases.

Authors:  Mariabeatrice Principi; Mario Mastrolonardo; Pietro Scicchitano; Michele Gesualdo; Marco Sassara; Piero Guida; Antongiulio Bucci; Annapaola Zito; Paola Caputo; Francesca Albano; Enzo Ierardi; Alfredo Di Leo; Marco Matteo Ciccone
Journal:  J Crohns Colitis       Date:  2013-03-07       Impact factor: 9.071

9.  Archaebiotics: proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease.

Authors:  Jean-François Brugère; Guillaume Borrel; Nadia Gaci; William Tottey; Paul W O'Toole; Corinne Malpuech-Brugère
Journal:  Gut Microbes       Date:  2013-10-31

Review 10.  Far from the eyes, close to the heart: dysbiosis of gut microbiota and cardiovascular consequences.

Authors:  Matteo Serino; Vincent Blasco-Baque; Simon Nicolas; Remy Burcelin
Journal:  Curr Cardiol Rep       Date:  2014-11       Impact factor: 2.931
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  14 in total

1.  Alterations in gut microbial function following liver transplant.

Authors:  Jasmohan S Bajaj; Genta Kakiyama; I Jane Cox; Hiroshi Nittono; Hajime Takei; Melanie White; Andrew Fagan; Edith A Gavis; Douglas M Heuman; Ho Chong Gilles; Phillip Hylemon; Simon D Taylor-Robinson; Cristina Legido-Quigley; Min Kim; Jin Xu; Roger Williams; Masoumeh Sikaroodi; William M Pandak; Patrick M Gillevet
Journal:  Liver Transpl       Date:  2018-05-13       Impact factor: 5.799

2.  Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice.

Authors:  Nan Xu; Pengcheng Kan; Xiuhua Yao; Ping Yang; Jiwei Wang; Lei Xiang; Yu Zhu
Journal:  J Microbiol       Date:  2018-10-24       Impact factor: 3.422

Review 3.  Microbial-derived antigens and metabolites in spondyloarthritis.

Authors:  Katharine Lu Yang; Alannah Lejeune; Gregory Chang; Jose U Scher; Sergei B Koralov
Journal:  Semin Immunopathol       Date:  2021-02-10       Impact factor: 11.759

Review 4.  Trimethylamine N-Oxide: The Good, the Bad and the Unknown.

Authors:  Manuel T Velasquez; Ali Ramezani; Alotaibi Manal; Dominic S Raj
Journal:  Toxins (Basel)       Date:  2016-11-08       Impact factor: 4.546

5.  Metagenomic data-mining reveals contrasting microbial populations responsible for trimethylamine formation in human gut and marine ecosystems.

Authors:  Eleanor Jameson; Andrew C Doxey; Ruth Airs; Kevin J Purdy; J Colin Murrell; Yin Chen
Journal:  Microb Genom       Date:  2016-09-20

Review 6.  Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut.

Authors:  Eleanor Jameson; Mussa Quareshy; Yin Chen
Journal:  Methods       Date:  2018-04-19       Impact factor: 3.608

7.  Targeted metabolomic analysis of plasma metabolites in patients with coronary heart disease in southern China.

Authors:  Zhixiong Zhong; Jing Liu; Qifeng Zhang; Wei Zhong; Bin Li; Cunren Li; Zhidong Liu; Min Yang; Pingsen Zhao
Journal:  Medicine (Baltimore)       Date:  2019-02       Impact factor: 1.817

Review 8.  Metabolic Interactions in the Gastrointestinal Tract (GIT): Host, Commensal, Probiotics, and Bacteriophage Influences.

Authors:  Luis Vitetta; Sean Hall; Samantha Coulson
Journal:  Microorganisms       Date:  2015-12-17

Review 9.  Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity.

Authors:  Jin Bu; Zhaohui Wang
Journal:  Gastroenterol Res Pract       Date:  2018-06-03       Impact factor: 2.260

10.  Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study.

Authors:  Yuxiang Dai; Qianqian Tian; Jing Si; Zhonghan Sun; Shalaimaiti Shali; Lili Xu; Daoyuan Ren; Shufu Chang; Xin Dong; Hongxia Zhao; Zhendong Mei; Yan Zheng; Junbo Ge
Journal:  Nutr Metab (Lond)       Date:  2020-05-24       Impact factor: 4.169
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