Literature DB >> 26309768

MEMS-based multiphoton endomicroscope for repetitive imaging of mouse colon.

Xiyu Duan1, Haijun Li2, Zhen Qiu3, Bishnu P Joshi2, Asha Pant2, Arlene Smith2, Katsuo Kurabayashi4, Kenn R Oldham5, Thomas D Wang6.   

Abstract

We demonstrate a handheld multiphoton endomicroscope with 3.4 mm distal diameter that can repetitively image mouse colon in vivo. A 2D resonant MEMS mirror was developed to perform beam scanning in a Lissajous pattern. The instrument has an effective numerical aperture of 0.63, lateral and axial resolution of 2.03 and 9.02 μm, respectively, working distance of 60 μm, and image field-of-view of 300 × 300 μm(2). Hoechst was injected intravenously in mice to stain cell nuclei. We were able to collect histology-like images in vivo at 5 frames/sec, and distinguish between normal and pre-malignant colonic epithelium.

Entities:  

Keywords:  (060.2350) Fiber optics imaging; (110.0110) Imaging systems; (170.0170) Medical optics and biotechnology; (170.2150) Endoscopic imaging; (190.4180) Multiphoton processes

Year:  2015        PMID： 26309768      PMCID： PMC4541532          DOI： 10.1364/BOE.6.003074

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  20 in total

1.  In vivo mammalian brain imaging using one- and two-photon fluorescence microendoscopy.

Authors:  Juergen C Jung; Amit D Mehta; Emre Aksay; Raymond Stepnoski; Mark J Schnitzer
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2.  Rigid and high-numerical-aperture two-photon fluorescence endoscope.

Authors:  R Le Harzic; I Riemann; M Weinigel; K König; B Messerschmidt
Journal:  Appl Opt       Date:  2009-06-20       Impact factor: 1.980

3.  Two-photon laser scanning fluorescence microscopy.

Authors:  W Denk; J H Strickler; W W Webb
Journal:  Science       Date:  1990-04-06       Impact factor: 47.728

4.  Vertical cross-sectional imaging of colonic dysplasia in vivo with multi-spectral dual axes confocal endomicroscopy.

Authors:  Zhen Qiu; Supang Khondee; Xiyu Duan; Haijun Li; Michael J Mandella; Bishnu P Joshi; Quan Zhou; Scott R Owens; Katsuo Kurabayashi; Kenn R Oldham; Thomas D Wang
Journal:  Gastroenterology       Date:  2014-01-15       Impact factor: 22.682

5.  Intravital microscopy to image membrane trafficking in live rats.

Authors:  Andrius Masedunskas; Monika Sramkova; Laura Parente; Roberto Weigert
Journal:  Methods Mol Biol       Date:  2013

6.  A compact fiber-optic SHG scanning endomicroscope and its application to visualize cervical remodeling during pregnancy.

Authors:  Yuying Zhang; Meredith L Akins; Kartikeya Murari; Jiefeng Xi; Ming-Jun Li; Katherine Luby-Phelps; Mala Mahendroo; Xingde Li
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-23       Impact factor: 11.205

7.  Ultra-compact fiber-optic two-photon microscope for functional fluorescence imaging in vivo.

Authors:  Christoph J Engelbrecht; Richard S Johnston; Eric J Seibel; Fritjof Helmchen
Journal:  Opt Express       Date:  2008-04-14       Impact factor: 3.894

8.  Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.

Authors:  Takao Hinoi; Aytekin Akyol; Brian K Theisen; David O Ferguson; Joel K Greenson; Bart O Williams; Kathleen R Cho; Eric R Fearon
Journal:  Cancer Res       Date:  2007-10-15       Impact factor: 12.701

9.  In vivo imaging of unstained tissues using long gradient index lens multiphoton endoscopic systems.

Authors:  David M Huland; Christopher M Brown; Scott S Howard; Dimitre G Ouzounov; Ina Pavlova; Ke Wang; David R Rivera; Watt W Webb; Chris Xu
Journal:  Biomed Opt Express       Date:  2012-04-19       Impact factor: 3.732

10.  Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

Authors:  Laila Ritsma; Saskia I J Ellenbroek; Anoek Zomer; Hugo J Snippert; Frederic J de Sauvage; Benjamin D Simons; Hans Clevers; Jacco van Rheenen
Journal:  Nature       Date:  2014-02-16       Impact factor: 49.962
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  12 in total

1.  Integrated monolithic 3D MEMS scanner for switchable real time vertical/horizontal cross-sectional imaging.

Authors:  Haijun Li; Xiyu Duan; Zhen Qiu; Quan Zhou; Katsuo Kurabayashi; Kenn R Oldham; Thomas D Wang
Journal:  Opt Express       Date:  2016-02-08       Impact factor: 3.894

2.  Motion Estimation for a Compact Electrostatic Microscanner via Shared Driving and Sensing Electrodes in Endomicroscopy.

Authors:  Yi Chen; Miki Lee; Mayur Bhushan Birla; Haijun Li; Gaoming Li; Xiyu Duan; Thomas D Wang; Kenn R Oldham
Journal:  IEEE ASME Trans Mechatron       Date:  2020-03-12       Impact factor: 5.303

3.  Handheld laser scanning microscope catheter for real-time and in vivo confocal microscopy using a high definition high frame rate Lissajous MEMS mirror.

Authors:  Jaehun Jeon; Hyunwoo Kim; Hyunwoo Jang; Kyungmin Hwang; Kyuyoung Kim; Young-Gyun Park; Ki-Hun Jeong
Journal:  Biomed Opt Express       Date:  2022-02-15       Impact factor: 3.732

4.  Multi-photon vertical cross-sectional imaging with a dynamically-balanced thin-film PZT z-axis microactuator.

Authors:  Jongsoo Choi; Xiyu Duan; Haijun Li; Thomas D Wang; Kenn R Oldham
Journal:  J Microelectromech Syst       Date:  2017-05-19       Impact factor: 2.417

5.  Label-free imaging for T staging of gastric carcinoma by multiphoton microscopy.

Authors:  Kexin He; Lili Zhao; Xiaoyang Huang; Ying Ding; Li Liu; Xiang Wang; Min Wang; Yong Zhang; Zhining Fan
Journal:  Lasers Med Sci       Date:  2018-02-06       Impact factor: 3.161

6.  Visualizing epithelial expression of EGFR in vivo with distal scanning side-viewing confocal endomicroscope.

Authors:  Xiyu Duan; Haijun Li; Juan Zhou; Quan Zhou; Kenn R Oldham; Thomas D Wang
Journal:  Sci Rep       Date:  2016-11-22       Impact factor: 4.379

7.  Lissajous Scanning Two-photon Endomicroscope for In vivo Tissue Imaging.

Authors:  Daniel Youngsuk Kim; Kyungmin Hwang; Jinhyo Ahn; Yeong-Hyeon Seo; Jae-Beom Kim; Soyoung Lee; Jin-Hui Yoon; Eunji Kong; Yong Jeong; Sangyong Jon; Pilhan Kim; Ki-Hun Jeong
Journal:  Sci Rep       Date:  2019-03-05       Impact factor: 4.379

8.  MEMS-in-the-lens architecture for a miniature high-NA laser scanning microscope.

Authors:  Tianbo Liu; Milind Rajadhyaksha; David L Dickensheets
Journal:  Light Sci Appl       Date:  2019-06-26       Impact factor: 17.782

Review 9.  Imaging of Mucosal Inflammation: Current Technological Developments, Clinical Implications, and Future Perspectives.

Authors:  Maximilian J Waldner; Timo Rath; Sebastian Schürmann; Christian Bojarski; Raja Atreya
Journal:  Front Immunol       Date:  2017-10-11       Impact factor: 7.561

Review 10.  MEMS Actuators for Optical Microendoscopy.

Authors:  Zhen Qiu; Wibool Piyawattanametha
Journal:  Micromachines (Basel)       Date:  2019-01-24       Impact factor: 2.891
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