| Literature DB >> 26290399 |
Brian V Balgobind1, Kees Koedooder1, Diego Ordoñez Zúñiga1, Raquel Dávila Fajardo1, Coen R N Rasch1, Bradley R Pieters1.
Abstract
Pulsed dose rate (PDR) brachytherapy is a treatment modality that combines physical advantages of high dose rate (HDR) brachytherapy with the radiobiological advantages of low dose rate brachytherapy. The aim of this review was to describe the effective clinical use of PDR brachytherapy worldwide in different tumour locations. We found 66 articles reporting on clinical PDR brachytherapy including the treatment procedure and outcome. Moreover, PDR brachytherapy has been applied in almost all tumour sites for which brachytherapy is indicated and with good local control and low toxicity. The main advantage of PDR is, because of the small pulse sizes used, the ability to spare normal tissue. In certain cases, HDR resembles PDR brachytherapy by the use of multifractionated low-fraction dose.Entities:
Mesh:
Year: 2015 PMID: 26290399 PMCID: PMC4743453 DOI: 10.1259/bjr.20150310
Source DB: PubMed Journal: Br J Radiol ISSN: 0007-1285 Impact factor: 3.039