Sabrina Boyrie1, Claire Charra-Brunaud2, Valentin Harter3, Anne Ducassou4, Youlia Kirova5, Isabelle Barillot6, Claude Krzisch7, Philippe Lang8, Marie-Hélène Baron9, Xavier Montbarbon10, Martine Delannes4, Didier Peiffert2. 1. Department of Radiotherapy, Institut Claudius Regaud, Toulouse, France. Electronic address: boyrie.sabrina@claudiusregaud.fr. 2. Department of Radiotherapy, Centre Alexis-Vautrin, Vandoeuvre-les-Nancy, France. 3. Department of Biostatistics, Centre Alexis-Vautrin, Vandoeuvre-les-Nancy, France. 4. Department of Radiotherapy, Institut Claudius Regaud, Toulouse, France. 5. Department of Radiotherapy, Institut Curie, Paris, France. 6. Department of Radiotherapy, Centre GF Leclerc, Dijon, France. 7. Department of Radiotherapy, Hopital Sud, Amiens, France. 8. Department of Radiotherapy, Hopital de la Pitié Salpétrière, Paris, France. 9. Department of Radiotherapy, Hopital J Minjoz, Besançon, France. 10. Department of Radiotherapy, Centre Léon Bérard, Lyon, France.
Abstract
PURPOSE: To investigate the impact of dose-volume histograms parameters on local control of three-dimensional (3D) image-based pulsed dose-rate brachytherapy (BT). METHODS AND MATERIALS: Within a French multicentric prospective study, the data of the 110 patients treated for cervical cancer with external beam radiotherapy followed by 3D image-based and optimized pulsed dose-rate BT were analyzed. Delineation procedures were performed on magnetic resonance imaging in a minority of cases and on CT for the majority of cases, adapted from the Gynaecological Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology recommendations. Optimization procedure was left to the discretion of the treating center. RESULTS: At 2 years, local control rate reached 78%. Dose to Point A, total reference air kerma, and intermediate-risk clinical target volume (IR-CTV) V60 were predictive factors for local control (p = 0.001, p = 0.001, and p = 0.013, respectively). Patients with IR-CTV V60 <75% had a relative risk of local recurrence of 3.8 (95% confidence interval, 1.4-11.1). There was no correlation found between the high-risk clinical target volume dosimetric parameters and local control. CONCLUSIONS: This multicentric study has shown that 3D image-based BT provides a high local control rate for cervical cancer patients. The V60 for IR-CTV was identified as an important predictive factor for local control.
PURPOSE: To investigate the impact of dose-volume histograms parameters on local control of three-dimensional (3D) image-based pulsed dose-rate brachytherapy (BT). METHODS AND MATERIALS: Within a French multicentric prospective study, the data of the 110 patients treated for cervical cancer with external beam radiotherapy followed by 3D image-based and optimized pulsed dose-rate BT were analyzed. Delineation procedures were performed on magnetic resonance imaging in a minority of cases and on CT for the majority of cases, adapted from the Gynaecological Groupe Européen de Curiethérapie-European Society for Therapeutic Radiology and Oncology recommendations. Optimization procedure was left to the discretion of the treating center. RESULTS: At 2 years, local control rate reached 78%. Dose to Point A, total reference air kerma, and intermediate-risk clinical target volume (IR-CTV) V60 were predictive factors for local control (p = 0.001, p = 0.001, and p = 0.013, respectively). Patients with IR-CTV V60 <75% had a relative risk of local recurrence of 3.8 (95% confidence interval, 1.4-11.1). There was no correlation found between the high-risk clinical target volume dosimetric parameters and local control. CONCLUSIONS: This multicentric study has shown that 3D image-based BT provides a high local control rate for cervical cancerpatients. The V60 for IR-CTV was identified as an important predictive factor for local control.
Authors: Brian V Balgobind; Kees Koedooder; Diego Ordoñez Zúñiga; Raquel Dávila Fajardo; Coen R N Rasch; Bradley R Pieters Journal: Br J Radiol Date: 2015-08-20 Impact factor: 3.039