Literature DB >> 26277695

A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents.

Chelsea Carpenter1, John Sidney1, Ravi Kolla1, Kaustuv Nayak2, Helena Tomiyama3, Claudia Tomiyama3, Oscar A Padilla3, Virginie Rozot4, Syed F Ahamed5, Carlos Ponte6, Valeria Rolla6, Paulo R Antas6, Anmol Chandele2, John Kenneth5, Seetha Laxmi7, Edward Makgotlho4, Valentina Vanini8, Giuseppe Ippolito8, Alexandra S Kazanova9, Alexander V Panteleev9, Willem Hanekom4, Harriet Mayanja-Kizza10, David Lewinsohn11, Mayuko Saito12, M Juliana McElrath13, W Henry Boom14, Delia Goletti8, Robert Gilman15, Irina V Lyadova9, Thomas J Scriba4, Esper G Kallas3, Kaja Murali-Krishna16, Alessandro Sette1, Cecilia S Lindestam Arlehamn17.   

Abstract

We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  BCG; CD4; LTBI; T cell antigen; Tuberculosis; Vaccine

Mesh：

Substances：

Year:  2015        PMID： 26277695      PMCID： PMC4666753          DOI： 10.1016/j.tube.2015.07.001

Source DB:  PubMed          Journal:  Tuberculosis (Edinb)        ISSN： 1472-9792            Impact factor:   3.131


  50 in total

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Journal:  Vaccine       Date:  2012-05-27       Impact factor: 3.641

Review 2.  Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosis.

Authors:  Jason R Andrews; Farzad Noubary; Rochelle P Walensky; Rodrigo Cerda; Elena Losina; C Robert Horsburgh
Journal:  Clin Infect Dis       Date:  2012-01-19       Impact factor: 9.079

3.  Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants.

Authors:  Thomas J Scriba; Michele Tameris; Nazma Mansoor; Erica Smit; Linda van der Merwe; Katya Mauff; E Jane Hughes; Sizulu Moyo; Nathaniel Brittain; Alison Lawrie; Humphrey Mulenga; Marwou de Kock; Sebastian Gelderbloem; Ashley Veldsman; Mark Hatherill; Hendrik Geldenhuys; Adrian V S Hill; Gregory D Hussey; Hassan Mahomed; Willem A Hanekom; Helen McShane
Journal:  J Infect Dis       Date:  2011-06-15       Impact factor: 5.226

4.  TubercuList--10 years after.

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Journal:  Tuberculosis (Edinb)       Date:  2010-10-25       Impact factor: 3.131

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Authors:  Jason Greenbaum; John Sidney; Jolan Chung; Christian Brander; Bjoern Peters; Alessandro Sette
Journal:  Immunogenetics       Date:  2011-02-09       Impact factor: 2.846

6.  An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection.

Authors:  Susanna Commandeur; Krista E van Meijgaarden; Corine Prins; Alexander V Pichugin; Karin Dijkman; Susan J F van den Eeden; Annemieke H Friggen; Kees L M C Franken; Gregory Dolganov; Igor Kramnik; Gary K Schoolnik; Fredrik Oftung; Gro Ellen Korsvold; Annemieke Geluk; Tom H M Ottenhoff
Journal:  J Immunol       Date:  2013-01-14       Impact factor: 5.422

7.  The candidate tuberculosis vaccine Mtb72F/AS02 in PPD positive adults: a randomized controlled phase I/II study.

Authors:  François Spertini; Régine Audran; Floriana Lurati; Opokua Ofori-Anyinam; Frédéric Zysset; Pierre Vandepapelière; Philippe Moris; Marie-Ange Demoitié; Pascal Mettens; Carlota Vinals; Ilse Vastiau; Erik Jongert; Joe Cohen; W Ripley Ballou
Journal:  Tuberculosis (Edinb)       Date:  2012-12-05       Impact factor: 3.131

8.  The candidate tuberculosis vaccine Mtb72F/AS02A: Tolerability and immunogenicity in humans.

Authors:  Kenneth Von Eschen; Royce Morrison; Madeleine Braun; Opokua Ofori-Anyinam; Els De Kock; Priya Pavithran; Marguerite Koutsoukos; Philippe Moris; Daniel Cain; Marie-Claude Dubois; Joe Cohen; W Ripley Ballou
Journal:  Hum Vaccin       Date:  2009-07-27

9.  The BCG World Atlas: a database of global BCG vaccination policies and practices.

Authors:  Alice Zwerling; Marcel A Behr; Aman Verma; Timothy F Brewer; Dick Menzies; Madhukar Pai
Journal:  PLoS Med       Date:  2011-03-22       Impact factor: 11.069

10.  Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.

Authors:  Cecilia S Lindestam Arlehamn; Anna Gerasimova; Federico Mele; Ryan Henderson; Justine Swann; Jason A Greenbaum; Yohan Kim; John Sidney; Eddie A James; Randy Taplitz; Denise M McKinney; William W Kwok; Howard Grey; Federica Sallusto; Bjoern Peters; Alessandro Sette
Journal:  PLoS Pathog       Date:  2013-01-24       Impact factor: 6.823
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  15 in total

1.  T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome.

Authors:  Anne Bresciani; Sinu Paul; Nina Schommer; Myles B Dillon; Tara Bancroft; Jason Greenbaum; Alessandro Sette; Morten Nielsen; Bjoern Peters
Journal:  Immunology       Date:  2016-02-08       Impact factor: 7.397

2.  Immunodominance in allergic T-cell reactivity to Japanese cedar in different geographic cohorts.

Authors:  Carla Oseroff; John Pham; April Frazier; Denise Hinz; John Sidney; Sinu Paul; Jason A Greenbaum; Randi Vita; Bjoern Peters; Véronique Schulten; Alessandro Sette
Journal:  Ann Allergy Asthma Immunol       Date:  2016-12       Impact factor: 6.347

3.  A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.

Authors:  Jennifer M Dan; Cecilia S Lindestam Arlehamn; Daniela Weiskopf; Ricardo da Silva Antunes; Colin Havenar-Daughton; Samantha M Reiss; Matthew Brigger; Marcella Bothwell; Alessandro Sette; Shane Crotty
Journal:  J Immunol       Date:  2016-06-24       Impact factor: 5.422

4.  Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23.

Authors:  Rubén Martínez-Barricarte; Janet G Markle; Cindy S Ma; Elissa K Deenick; Noé Ramírez-Alejo; Federico Mele; Daniela Latorre; Seyed Alireza Mahdaviani; Caner Aytekin; Davood Mansouri; Vanessa L Bryant; Fabienne Jabot-Hanin; Caroline Deswarte; Alejandro Nieto-Patlán; Laura Surace; Gaspard Kerner; Yuval Itan; Sandra Jovic; Danielle T Avery; Natalie Wong; Geetha Rao; Etienne Patin; Satoshi Okada; Benedetta Bigio; Bertrand Boisson; Franck Rapaport; Yoann Seeleuthner; Monika Schmidt; Aydan Ikinciogullari; Figen Dogu; Gonul Tanir; Payam Tabarsi; Mohammed Reza Bloursaz; Julia K Joseph; Avneet Heer; Xiao-Fei Kong; Mélanie Migaud; Tomi Lazarov; Frédéric Geissmann; Bernhard Fleckenstein; Cecilia Lindestam Arlehamn; Alessandro Sette; Anne Puel; Jean-François Emile; Esther van de Vosse; Lluis Quintana-Murci; James P Di Santo; Laurent Abel; Stéphanie Boisson-Dupuis; Jacinta Bustamante; Stuart G Tangye; Federica Sallusto; Jean-Laurent Casanova
Journal:  Sci Immunol       Date:  2018-12-21

5.  A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

Authors:  Cecilia S Lindestam Arlehamn; Denise M McKinney; Chelsea Carpenter; Sinu Paul; Virginie Rozot; Edward Makgotlho; Yolande Gregg; Michele van Rooyen; Joel D Ernst; Mark Hatherill; Willem A Hanekom; Bjoern Peters; Thomas J Scriba; Alessandro Sette
Journal:  PLoS Pathog       Date:  2016-07-13       Impact factor: 6.823

6.  New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles.

Authors:  Mariateresa Coppola; Krista E van Meijgaarden; Kees L M C Franken; Susanna Commandeur; Gregory Dolganov; Igor Kramnik; Gary K Schoolnik; Inaki Comas; Ole Lund; Corine Prins; Susan J F van den Eeden; Gro E Korsvold; Fredrik Oftung; Annemieke Geluk; Tom H M Ottenhoff
Journal:  Sci Rep       Date:  2016-11-28       Impact factor: 4.379

7.  Risk factors for increased immune reconstitution in response to Mycobacterium tuberculosis antigens in tuberculosis HIV-infected, antiretroviral-naïve patients.

Authors:  Tatiana Pereira da Silva; Carmem Beatriz Wagner Giacoia-Gripp; Carolina A Schmaltz; Flavia Marinho Sant'Anna; Maria Helena Saad; Juliana Arruda de Matos; Julio Castro Alves de Lima E Silva; Valeria Cavalcanti Rolla; Mariza Gonçalves Morgado
Journal:  BMC Infect Dis       Date:  2017-09-06       Impact factor: 3.090

8.  Multi-subunit BCG booster vaccine GamTBvac: Assessment of immunogenicity and protective efficacy in murine and guinea pig TB models.

Authors:  A P Tkachuk; V A Gushchin; V D Potapov; A V Demidenko; V G Lunin; A L Gintsburg
Journal:  PLoS One       Date:  2017-04-28       Impact factor: 3.240

9.  A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.

Authors:  Wendy E Whatney; Neel R Gandhi; Cecilia S Lindestam Arlehamn; Azhar Nizam; Hao Wu; Melanie J Quezada; Angela Campbell; Salim Allana; Mbuyi Madeleine Kabongo; Jeremiah Khayumbi; Benson Muchiri; Joshua Ongalo; Joan Tonui; Loren E Sasser; Tawania J Fergus; Gregory Sadat Ouma; Samuel Gurrion Ouma; Allison A Beck; Mark J Mulligan; Alawode Oladele; Deepak Kaushal; Kevin P Cain; Lance Waller; Henry M Blumberg; John D Altman; Joel D Ernst; Jyothi Rengarajan; Cheryl L Day
Journal:  J Immunol       Date:  2018-03-14       Impact factor: 5.426

Review 10.  A review of clinical models for the evaluation of human TB vaccines.

Authors:  Matthew K O'Shea; Helen McShane
Journal:  Hum Vaccin Immunother       Date:  2016-01-25       Impact factor: 3.452
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