Jingyu Cai1, Jianhua Xu1, Kang Wang1, Shuang Zheng1, Fan He1, Shuting Huan1, Shengqing Xu1, Hui Zhang1, Laura Laslett1, Changhai Ding2. 1. From the Department of Rheumatology and Immunology, Arthritis Research Institute, and the Department of Medical Images, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.J. Cai, MMed; J. Xu, MD; K. Wang, MD; S. Zheng, MMed; F. He, MMed; S. Huan, MMed; S. Xu, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University; H. Zhang, MMed, Department of Medical Image, the First Affiliated Hospital of Anhui Medical University; L. Laslett, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University; C. Ding, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, and Menzies Institute for Medical Research, University of Tasmania. 2. From the Department of Rheumatology and Immunology, Arthritis Research Institute, and the Department of Medical Images, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.J. Cai, MMed; J. Xu, MD; K. Wang, MD; S. Zheng, MMed; F. He, MMed; S. Huan, MMed; S. Xu, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University; H. Zhang, MMed, Department of Medical Image, the First Affiliated Hospital of Anhui Medical University; L. Laslett, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University; C. Ding, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, and Menzies Institute for Medical Research, University of Tasmania. changhai.ding@utas.edu.au.
Abstract
OBJECTIVE: The function of the infrapatellar fat pad (IPFP) in knee osteoarthritis (OA) remains uncertain. This study aimed to examine cross-sectional associations between IPFP volume and knee structures in patients with knee OA. METHODS: The study included 174 patients with clinical knee OA (mean age, 55.5 yrs). Fat-suppressed 3-D T1-weighted spoiled gradient recall magnetic resonance imaging (MRI) was used to measure the IPFP and cartilage volume. T2-weighted fast spin echo MRI was used to assess cartilage defects and bone marrow lesions (BML). Radiographic knee osteophytes and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. RESULTS: After adjustment for potential confounders, greater IPFP volume was associated with greater tibial and patellar cartilage volume (all p < 0.05), and fewer cartilage defects at all sites (OR 0.88-0.91, all p < 0.05). IPFP volume was associated with presence of BML at lateral tibial and medial femoral sites (OR 0.88-0.91, all p < 0.05) and osteophytes at lateral tibiofemoral compartment (OR 0.88, p < 0.05). IPFP volume was not significantly associated with JSN. CONCLUSION: Greater IPFP volume was associated with greater knee cartilage volume and fewer structural abnormalities, suggesting a protective role of IPFP size in knee OA.
OBJECTIVE: The function of the infrapatellar fat pad (IPFP) in knee osteoarthritis (OA) remains uncertain. This study aimed to examine cross-sectional associations between IPFP volume and knee structures in patients with knee OA. METHODS: The study included 174 patients with clinical knee OA (mean age, 55.5 yrs). Fat-suppressed 3-D T1-weighted spoiled gradient recall magnetic resonance imaging (MRI) was used to measure the IPFP and cartilage volume. T2-weighted fast spin echo MRI was used to assess cartilage defects and bone marrow lesions (BML). Radiographic knee osteophytes and joint space narrowing (JSN) were assessed using the Osteoarthritis Research Society International atlas. RESULTS: After adjustment for potential confounders, greater IPFP volume was associated with greater tibial and patellar cartilage volume (all p < 0.05), and fewer cartilage defects at all sites (OR 0.88-0.91, all p < 0.05). IPFP volume was associated with presence of BML at lateral tibial and medial femoral sites (OR 0.88-0.91, all p < 0.05) and osteophytes at lateral tibiofemoral compartment (OR 0.88, p < 0.05). IPFP volume was not significantly associated with JSN. CONCLUSION: Greater IPFP volume was associated with greater knee cartilage volume and fewer structural abnormalities, suggesting a protective role of IPFP size in knee OA.
Authors: A Ruhdorfer; F Haniel; T Petersohn; J Dörrenberg; W Wirth; T Dannhauer; D J Hunter; F Eckstein Journal: Osteoarthritis Cartilage Date: 2017-02-12 Impact factor: 6.576
Authors: Benedikt J Schwaiger; John Mbapte Wamba; Alexandra S Gersing; Michael C Nevitt; Luca Facchetti; Charles E McCulloch; Thomas M Link Journal: Skeletal Radiol Date: 2017-09-24 Impact factor: 2.199
Authors: Aarón Leonardo Pogacnik Murillo; Felix Eckstein; Wolfgang Wirth; Daniel Beavers; Richard F Loeser; Barbara J Nicklas; Shannon L Mihalko; Gary D Miller; David J Hunter; Stephen P Messier Journal: Cells Tissues Organs Date: 2017-02-22 Impact factor: 2.481
Authors: Zhenhong Ni; Siru Zhou; Song Li; Liang Kuang; Hangang Chen; Xiaoqing Luo; Junjie Ouyang; Mei He; Xiaolan Du; Lin Chen Journal: Bone Res Date: 2020-06-19 Impact factor: 13.567
Authors: Rianne A van der Heijden; Bas A de Vries; Dirk H J Poot; Marienke van Middelkoop; Sita M A Bierma-Zeinstra; Gabriel P Krestin; Edwin H G Oei Journal: Quant Imaging Med Surg Date: 2021-01