Guangfeng Ruan1,2,3, Jianhua Xu1, Kang Wang1, Shuang Zheng1,2, Juan Wu1, Fuqin Bian1, Bingru Chang1, Yan Zhang2,3, Tao Meng2, Zhaohua Zhu2,3, Weiyu Han2,3, Changhai Ding4,5,6. 1. Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Street, Hefei, Anhui, China. 2. Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia. 3. Clinical Research Centre, Zhujiang Hospital, Southern Medical University, No. 253, Middle Gongye Avenue, Guangzhou, Guangdong, China. 4. Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Street, Hefei, Anhui, China. changhai.ding@utas.edu.au. 5. Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia. changhai.ding@utas.edu.au. 6. Clinical Research Centre, Zhujiang Hospital, Southern Medical University, No. 253, Middle Gongye Avenue, Guangzhou, Guangdong, China. changhai.ding@utas.edu.au.
Abstract
OBJECTIVE: The aim of this study was to investigate cross-sectional associations between serum levels of IL-8 and the above outcomes in patients with knee osteoarthritis (OA). METHODS: A total of 160 subjects with clinical knee OA were included. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and Lequesne index were used to assess the joint symptom. Magnetic resonance imaging was used to measure knee structural abnormalities including infrapatellar fat pad (IPFP) signal intensity alternation. Knee radiographic OA was assessed by radiography using the Kellgren-Lawrence (K-L) grading system. Enzyme-linked immunosorbent assay was used to measure the serum levels of IL-8 and cartilage or bone biomarkers. RESULTS: In multivariable analyses, serum IL-8 was positively associated with WOMAC weight-bearing pain (β 2.85, P = 0.028), WOMAC physical dysfunction (β 12.71, P = 0.048), and Lequesne index (β 1.65, P = 0.015), and had positive associations with IPFP signal intensity alteration (OR 3.18, P = 0.011) and serum levels of N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), matrix metalloproteinase (MMP)3, and MMP13 (β 0.24-1.44, all P < 0.05) in patients with clinical knee OA. Furthermore, there were positive associations between IL-8 and WOMAC score (β 22.49, P = 0.037), K-L grades (OR 3.88, P = 0.013), and IPFP signal intensity alteration (OR 3.20, P = 0.033) in patients with radiographic OA. CONCLUSIONS: Serum levels of IL-8 were positively associated with increased knee symptoms, IPFP signal intensity alteration, and serum levels of bone and/or cartilage biomarkers, suggesting that IL-8 may have a role to play in knee OA.Key Point• This study systemically investigates the associations between serum IL 8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis, and some significant associations have been found, suggesting that IL 8 may have a role to play in knee OA.
OBJECTIVE: The aim of this study was to investigate cross-sectional associations between serum levels of IL-8 and the above outcomes in patients with knee osteoarthritis (OA). METHODS: A total of 160 subjects with clinical knee OA were included. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and Lequesne index were used to assess the joint symptom. Magnetic resonance imaging was used to measure knee structural abnormalities including infrapatellar fat pad (IPFP) signal intensity alternation. Knee radiographic OA was assessed by radiography using the Kellgren-Lawrence (K-L) grading system. Enzyme-linked immunosorbent assay was used to measure the serum levels of IL-8 and cartilage or bone biomarkers. RESULTS: In multivariable analyses, serum IL-8 was positively associated with WOMAC weight-bearing pain (β 2.85, P = 0.028), WOMAC physical dysfunction (β 12.71, P = 0.048), and Lequesne index (β 1.65, P = 0.015), and had positive associations with IPFP signal intensity alteration (OR 3.18, P = 0.011) and serum levels of N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), matrix metalloproteinase (MMP)3, and MMP13 (β 0.24-1.44, all P < 0.05) in patients with clinical knee OA. Furthermore, there were positive associations between IL-8 and WOMAC score (β 22.49, P = 0.037), K-L grades (OR 3.88, P = 0.013), and IPFP signal intensity alteration (OR 3.20, P = 0.033) in patients with radiographic OA. CONCLUSIONS: Serum levels of IL-8 were positively associated with increased knee symptoms, IPFP signal intensity alteration, and serum levels of bone and/or cartilage biomarkers, suggesting that IL-8 may have a role to play in knee OA.Key Point• This study systemically investigates the associations between serum IL 8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis, and some significant associations have been found, suggesting that IL 8 may have a role to play in knee OA.
Entities:
Keywords:
IL-8; Magnetic resonance imaging; Osteoarthritis
Authors: D J Hunter; A Guermazi; G H Lo; A J Grainger; P G Conaghan; R M Boudreau; F W Roemer Journal: Osteoarthritis Cartilage Date: 2011-05-23 Impact factor: 6.576
Authors: Frank W Roemer; C Kent Kwoh; Michael J Hannon; David J Hunter; Felix Eckstein; Tomoko Fujii; Robert M Boudreau; Ali Guermazi Journal: Arthritis Rheumatol Date: 2015-05 Impact factor: 10.995
Authors: William H Robinson; Christin M Lepus; Qian Wang; Harini Raghu; Rong Mao; Tamsin M Lindstrom; Jeremy Sokolove Journal: Nat Rev Rheumatol Date: 2016-08-19 Impact factor: 20.543
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: F W Roemer; M Jarraya; D T Felson; D Hayashi; M D Crema; D Loeuille; A Guermazi Journal: Osteoarthritis Cartilage Date: 2015-10-09 Impact factor: 6.576
Authors: Lei Ding; Cheng Zhou; Hongjun Zheng; Quanming Wang; Haiyan Song; Joseph A Buckwalter; James A Martin Journal: Cartilage Date: 2021-10-12 Impact factor: 3.117
Authors: Eiva Bernotiene; Edvardas Bagdonas; Gailute Kirdaite; Paulius Bernotas; Ursule Kalvaityte; Ilona Uzieliene; Christian S Thudium; Heidi Hannula; Gabriela S Lorite; Mona Dvir-Ginzberg; Ali Guermazi; Ali Mobasheri Journal: Front Med (Lausanne) Date: 2020-10-21