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Literature DB >> 31181927

Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium, Microbulbifer sp.

Dinith R Jayanetti¹, Doug R Braun¹, Kenneth J Barns¹, Scott R Rajski¹, Tim S Bugni¹.

Abstract

Here we report the discovery of two new 3-acetamido-4-hydroxybenzoate esters, bulbiferates A (1) and B (2), isolated from Microbulbifer sp. cultivated from the marine tunicate Ecteinascidia turbinata. The structures of 1 and 2 were determined by analysis of 2D NMR and MS data. Additionally, three synthetic analogues (3-5), differing in ester sizes/lengths, were prepared for the purposes of evaluating potential structure-activity relationships; no clear correlations tying ester lengths to activity were evident. Bulbiferates A (1) and B (2) demonstrated antibacterial activity against both Escherichia coli (E. coli) and methicillin-sensitive Staphylococcus aureus (MSSA), whereas the synthetic analogues 3 and 4 displayed activity only against MSSA.

Entities: CellLine Chemical Disease Species

Mesh：

Substances：
Anti-Bacterial Agents

Year: 2019 PMID： 31181927 PMCID： PMC6660402 DOI： 10.1021/acs.jnatprod.9b00312

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

28 in total

1. Natural assemblages of marine proteobacteria and members of the Cytophaga-Flavobacter cluster consuming low- and high-molecular-weight dissolved organic matter.

Authors: M T Cottrell; D L Kirchman
Journal: Appl Environ Microbiol Date: 2000-04 Impact factor: 4.792

2. Bacterioplankton compositions of lakes and oceans: a first comparison based on fluorescence in situ hybridization.

Authors: F O Glöckner; B M Fuchs; R Amann
Journal: Appl Environ Microbiol Date: 1999-08 Impact factor: 4.792

3. Community composition of marine bacterioplankton determined by 16S rRNA gene clone libraries and fluorescence in situ hybridization.

Authors: M T Cottrell; D L Kirchman
Journal: Appl Environ Microbiol Date: 2000-12 Impact factor: 4.792

Review 4. The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes.

Authors: R S Gupta
Journal: FEMS Microbiol Rev Date: 2000-10 Impact factor: 16.408

5. Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates.

Authors: Thorsten Brinkhoff; Gabriela Bach; Thorsten Heidorn; Lanfang Liang; Andrea Schlingloff; Meinhard Simon
Journal: Appl Environ Microbiol Date: 2004-04 Impact factor: 4.792

3. Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

Authors: Amit Raj Sharma; Enjuro Harunari; Tao Zhou; Agus Trianto; Yasuhiro Igarashi
Journal: Beilstein J Org Chem Date: 2019-09-30 Impact factor: 2.883

4. Quorum Quenching Strains Isolated from the Microbiota of Sea Anemones and Holothurians Attenuate Vibriocorallilyticus Virulence Factors and Reduce Mortality in Artemiasalina.

Authors: José Carlos Reina; Pedro Pérez; Inmaculada Llamas
Journal: Microorganisms Date: 2022-03-16

4 in total

Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium, Microbulbifer sp.

1. Natural assemblages of marine proteobacteria and members of the Cytophaga-Flavobacter cluster consuming low- and high-molecular-weight dissolved organic matter.

2. Bacterioplankton compositions of lakes and oceans: a first comparison based on fluorescence in situ hybridization.

3. Community composition of marine bacterioplankton determined by 16S rRNA gene clone libraries and fluorescence in situ hybridization.

Review 4. The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes.

5. Antibiotic production by a Roseobacter clade-affiliated species from the German Wadden Sea and its antagonistic effects on indigenous isolates.

6. Phylogeny of Proteobacteria and Bacteroidetes from oxic habitats of a tidal flat ecosystem.

7. Culturability and In situ abundance of pelagic bacteria from the North Sea.

8. Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp.

9. Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl esters, parabens.

10. Microbulbifer salipaludis sp. nov., a moderate halophile isolated from a Korean salt marsh.

1. Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from Globimetula braunii Leaf.

Review 2. Marine Natural Products from Tunicates and Their Associated Microbes.

3. Isolation and biosynthesis of an unsaturated fatty acid with unusual methylation pattern from a coral-associated bacterium Microbulbifer sp.

4. Quorum Quenching Strains Isolated from the Microbiota of Sea Anemones and Holothurians Attenuate Vibriocorallilyticus Virulence Factors and Reduce Mortality in Artemiasalina.