Patrick Fleming1, John Kraft2, Wayne P Gulliver3, Charles Lynde4. 1. Division of Dermatology, University of Toronto, Toronto, Canada flemingp@mun.ca. 2. Lynde Dermatology (Private Practice), Markham, Canada. 3. Department of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada. 4. Division of Dermatology, University of Toronto, Toronto, Canada Lynde Dermatology (Private Practice), Markham, Canada.
Abstract
BACKGROUND: Psoriasis is a chronic inflammatory disease associated with obesity. The increased production of adipocytokines in central adiposity contributes to the systemic inflammation of obesity and perhaps to psoriasis. OBJECTIVE: The objective of this systematic review is to determine the association of obesity with psoriasis severity. METHODS: We searched PubMed, EMBASE, and Cochrane Database for English-language papers involving human subjects for all years. We extracted data on age, sex, body mass index (BMI), proportion obese, and psoriasis severity index score (PASI). RESULTS: We identified 254 articles in our search and included 9. The sample size was 134 823 psoriasis patients. Seven of the 9 studies found a statistically significant association of increased psoriasis severity with higher BMI. CONCLUSION: Increased severity of psoriasis appears to be associated with increased BMI. Most studies were cross-sectional or case-control, making it difficult to determine temporality. Dermatologists should consider recording BMI for psoriasis patients and offering them lifestyle counseling.
BACKGROUND:Psoriasis is a chronic inflammatory disease associated with obesity. The increased production of adipocytokines in central adiposity contributes to the systemic inflammation of obesity and perhaps to psoriasis. OBJECTIVE: The objective of this systematic review is to determine the association of obesity with psoriasis severity. METHODS: We searched PubMed, EMBASE, and Cochrane Database for English-language papers involving human subjects for all years. We extracted data on age, sex, body mass index (BMI), proportion obese, and psoriasis severity index score (PASI). RESULTS: We identified 254 articles in our search and included 9. The sample size was 134 823 psoriasispatients. Seven of the 9 studies found a statistically significant association of increased psoriasis severity with higher BMI. CONCLUSION: Increased severity of psoriasis appears to be associated with increased BMI. Most studies were cross-sectional or case-control, making it difficult to determine temporality. Dermatologists should consider recording BMI for psoriasispatients and offering them lifestyle counseling.
Authors: Martin P Playford; Amit K Dey; Claudia Zierold; Aditya A Joshi; Frank Blocki; Fabrizio Bonelli; Justin A Rodante; Charlotte L Harrington; Joshua P Rivers; Youssef A Elnabawi; Marcus Y Chen; Mark A Ahlman; Heather L Teague; Nehal N Mehta Journal: Atherosclerosis Date: 2019-08-17 Impact factor: 5.162
Authors: Charlotte L Harrington; Amit K Dey; Raza Yunus; Aditya A Joshi; Nehal N Mehta Journal: Am J Physiol Heart Circ Physiol Date: 2017-03-03 Impact factor: 4.733
Authors: Joshua P Rivers; Tiffany M Powell-Wiley; Amit K Dey; Justin A Rodante; Jonathan H Chung; Aditya A Joshi; Balaji Natarajan; Aparna P Sajja; Abhishek Chaturvedi; Anshuma Rana; Charlotte L Harrington; Heather L Teague; Benjamin N Lockshin; Mark A Ahlman; Jianhua Yao; Martin P Playford; Joel M Gelfand; Nehal N Mehta Journal: JACC Cardiovasc Imaging Date: 2017-10-18
Authors: Luigi Barrea; Francesca Nappi; Carolina Di Somma; Maria Cristina Savanelli; Andrea Falco; Anna Balato; Nicola Balato; Silvia Savastano Journal: Int J Environ Res Public Health Date: 2016-07-22 Impact factor: 3.390