G E Sanda1, A D Belur1, H L Teague1, Nehal N Mehta2. 1. Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, NIH, 10 Center Drive, CRC, Room 5-5140, Bethesda, MD, 20892, USA. 2. Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, NIH, 10 Center Drive, CRC, Room 5-5140, Bethesda, MD, 20892, USA. nehal.mehta@nih.gov.
Abstract
PURPOSE OF REVIEW: Atherogenesis, once thought to be a passive process, is now recognized as a dynamic, immune-driven process. The critical innate immune cells, including neutrophils, normal-density granulocytes, and their newly identified subset low-density granulocytes, are moving to the forefront of interest in cardiovascular medicine due to their abundance in atherosclerotic plaques and chronic inflammatory diseases associating with early cardiovascular disease (CVD) such as psoriasis. In this review, we discuss the emerging roles of neutrophils in CVD and how they play a potential role in early CVD observed in psoriasis patients. This review aims to describe the roles of neutrophils in both early atherosclerosis and psoriasis. RECENT FINDINGS: Recent work has demonstrated mechanistic links between vascular inflammation and neutrophil frequency. Evolving mouse models and clinical trials targeting IL-17-associated pathways continue to elucidate contributions of neutrophils in both atherosclerosis and psoriasis. Early animal, in vitro and human studies suggest an important emerging role of neutrophils in atherosclerosis and psoriasis.
PURPOSE OF REVIEW: Atherogenesis, once thought to be a passive process, is now recognized as a dynamic, immune-driven process. The critical innate immune cells, including neutrophils, normal-density granulocytes, and their newly identified subset low-density granulocytes, are moving to the forefront of interest in cardiovascular medicine due to their abundance in atherosclerotic plaques and chronic inflammatory diseases associating with early cardiovascular disease (CVD) such as psoriasis. In this review, we discuss the emerging roles of neutrophils in CVD and how they play a potential role in early CVD observed in psoriasispatients. This review aims to describe the roles of neutrophils in both early atherosclerosis and psoriasis. RECENT FINDINGS: Recent work has demonstrated mechanistic links between vascular inflammation and neutrophil frequency. Evolving mouse models and clinical trials targeting IL-17-associated pathways continue to elucidate contributions of neutrophils in both atherosclerosis and psoriasis. Early animal, in vitro and human studies suggest an important emerging role of neutrophils in atherosclerosis and psoriasis.
Authors: Eneida Villanueva; Srilakshmi Yalavarthi; Celine C Berthier; Jeffrey B Hodgin; Ritika Khandpur; Andrew M Lin; Cory J Rubin; Wenpu Zhao; Stephen H Olsen; Matthew Klinker; David Shealy; Michael F Denny; Joel Plumas; Laurence Chaperot; Matthias Kretzler; Allen T Bruce; Mariana J Kaplan Journal: J Immunol Date: 2011-05-25 Impact factor: 5.422
Authors: Nehal N Mehta; YiDing Yu; Rebecca Pinnelas; Parasuram Krishnamoorthy; Daniel B Shin; Andrea B Troxel; Joel M Gelfand Journal: Am J Med Date: 2011-08 Impact factor: 4.965
Authors: Lam C Tsoi; Sarah L Spain; Jo Knight; Eva Ellinghaus; Philip E Stuart; Francesca Capon; Jun Ding; Yanming Li; Trilokraj Tejasvi; Johann E Gudjonsson; Hyun M Kang; Michael H Allen; Ross McManus; Giuseppe Novelli; Lena Samuelsson; Joost Schalkwijk; Mona Ståhle; A David Burden; Catherine H Smith; Michael J Cork; Xavier Estivill; Anne M Bowcock; Gerald G Krueger; Wolfgang Weger; Jane Worthington; Rachid Tazi-Ahnini; Frank O Nestle; Adrian Hayday; Per Hoffmann; Juliane Winkelmann; Cisca Wijmenga; Cordelia Langford; Sarah Edkins; Robert Andrews; Hannah Blackburn; Amy Strange; Gavin Band; Richard D Pearson; Damjan Vukcevic; Chris C A Spencer; Panos Deloukas; Ulrich Mrowietz; Stefan Schreiber; Stephan Weidinger; Sulev Koks; Külli Kingo; Tonu Esko; Andres Metspalu; Henry W Lim; John J Voorhees; Michael Weichenthal; H Erich Wichmann; Vinod Chandran; Cheryl F Rosen; Proton Rahman; Dafna D Gladman; Christopher E M Griffiths; Andre Reis; Juha Kere; Rajan P Nair; Andre Franke; Jonathan N W N Barker; Goncalo R Abecasis; James T Elder; Richard C Trembath Journal: Nat Genet Date: 2012-11-11 Impact factor: 38.330
Authors: Elena Galkina; Alexandra Kadl; John Sanders; Danielle Varughese; Ian J Sarembock; Klaus Ley Journal: J Exp Med Date: 2006-05-08 Impact factor: 14.307
Authors: Vishnu Hosur; Daniel A Skelly; Christopher Francis; Benjamin E Low; Vivek Kohar; Lisa M Burzenski; Mansoor M Amiji; Leonard D Shultz; Michael V Wiles Journal: Drug Discov Today Date: 2020-05-05 Impact factor: 7.851
Authors: Erik Taylor; Nasi Huang; Jacob Bodde; Andrew Ellison; Ronald Killiany; Markus Michael Bachschmid; James Hamilton Journal: J Transl Med Date: 2018-08-01 Impact factor: 5.531
Authors: Stephanie T Le; Alexander A Merleev; Guillaume Luxardi; Michiko Shimoda; Iannis E Adamopoulos; Lam C Tsoi; Jenny Z Wang; Claire Alexanian; Siba P Raychaudhuri; Samuel T Hwang; Johann Gudjonsson; Alina I Marusina; Emanual Maverakis Journal: Front Immunol Date: 2019-04-04 Impact factor: 7.561
Authors: Yan Zhou; Dan Han; Taylor Follansbee; Xuesong Wu; Sebastian Yu; Bo Wang; Zhenrui Shi; Dan T Domocos; Mirela Carstens; Earl Carstens; Samuel T Hwang Journal: J Cell Mol Med Date: 2019-05-21 Impact factor: 5.310