Asiye Kanbay1, Neslihan Cerrah Demir2, Nuri Tutar2, Osman Köstek3, Zuhal Özer Şimşek2, Hakan Buyukoglan2, Ramazan Demir2, Liborio Parrino4. 1. Department of Pulmonary Medicine, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey. 2. Department of Pulmonary Medicine, Erciyes University School of Medicine, Kayseri, Turkey. 3. Department of Internal Medicine, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey. 4. Department of Neurosciences, Sleep Disorders Center, University of Parma, Parma, Italy.
Abstract
OBJECTIVES: Cognitive impairment is common among patients with obstructive sleep apnea syndrome (OSAS). In this study, we aimed to investigate the effect of continuous positive airway pressure (CPAP) therapy on serum insulin-like growth factor-1 (IGF-1) levels and cognitive functions in patients with OSAS. PATIENT/ METHODS: Thirty-three patients with newly diagnosed OSAS and 17 healthy-control subjects enrolled in the study. All individuals completed the mini-mental state examination (MMSE) to evaluate cognitive function. Blood samples were taken at the end of the polysomnography in the morning and the same procedures were repeated 3 months after starting CPAP treatment. RESULTS: In the OSAS group, the baseline MMSE score was 23.5 ± 3.6, and serum IGF-1 level was 79.1 ± 36.1 ng/mL. Both values were significantly lower compared with the control group (mean MMSE score = 28.1 ± 1.4, P = 0.0001; mean serum IGF-1 level = 147.1 ± 49.1 ng/mL, P < 0.0001). Three months after CPAP treatment, OSAS patients showed a significant improvement in MMSE scores (26.5 ± 2.8, P = 0.0001) and serum IGF-1 level (129.1 ± 58.2, P = 0.0001). In contrast, baseline and third-month measurements for IGF-1 levels and MMSE scores were not significantly different in the control group. CONCLUSIONS: The results indicate that effective CPAP therapy in OSAS patients leads to significant improvement in cognitive functions and IGF-1 even in a short-term follow-up. Cognitive function assessment might be a part of evaluation in OSAS patients.
OBJECTIVES:Cognitive impairment is common among patients with obstructive sleep apnea syndrome (OSAS). In this study, we aimed to investigate the effect of continuous positive airway pressure (CPAP) therapy on serum insulin-like growth factor-1 (IGF-1) levels and cognitive functions in patients with OSAS. PATIENT/ METHODS: Thirty-three patients with newly diagnosed OSAS and 17 healthy-control subjects enrolled in the study. All individuals completed the mini-mental state examination (MMSE) to evaluate cognitive function. Blood samples were taken at the end of the polysomnography in the morning and the same procedures were repeated 3 months after starting CPAP treatment. RESULTS: In the OSAS group, the baseline MMSE score was 23.5 ± 3.6, and serum IGF-1 level was 79.1 ± 36.1 ng/mL. Both values were significantly lower compared with the control group (mean MMSE score = 28.1 ± 1.4, P = 0.0001; mean serum IGF-1 level = 147.1 ± 49.1 ng/mL, P < 0.0001). Three months after CPAP treatment, OSAS patients showed a significant improvement in MMSE scores (26.5 ± 2.8, P = 0.0001) and serum IGF-1 level (129.1 ± 58.2, P = 0.0001). In contrast, baseline and third-month measurements for IGF-1 levels and MMSE scores were not significantly different in the control group. CONCLUSIONS: The results indicate that effective CPAP therapy in OSAS patients leads to significant improvement in cognitive functions and IGF-1 even in a short-term follow-up. Cognitive function assessment might be a part of evaluation in OSAS patients.
Authors: Andreas Palm; Christian Berne; Helena Igelström; Pernilla Åsenlöf; Christer Janson; Eva Lindberg Journal: J Clin Sleep Med Date: 2018-03-15 Impact factor: 4.062
Authors: Chitra Lal; Indu Ayappa; Najib Ayas; Andrew E Beaudin; Camilla Hoyos; Clete A Kushida; Marta Kaminska; Anna Mullins; Sharon L Naismith; Ricardo S Osorio; Craig L Phillips; Ankit Parekh; Katie L Stone; Arlener D Turner; Andrew W Varga Journal: Ann Am Thorac Soc Date: 2022-08