Andreas Palm1,2, Christian Berne3, Helena Igelström4, Pernilla Åsenlöf4, Christer Janson1, Eva Lindberg1. 1. Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden. 2. Centre for Research and Development, Uppsala University, Region Gävleborg, Gävle, Sweden. 3. Department of Medical Sciences, Clinical Diabetology and Metabolism, Uppsala University, Uppsala, Sweden. 4. Department of Neuroscience, Section of Physiotherapy, Uppsala University, Uppsala, Sweden.
Abstract
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is a disease with metabolic and cardiovascular consequences and is associated with decreased serum concentrations of insulin-like growth factor-1 (IGF-1). The aim of this study was to investigate whether continuous positive airway pressure (CPAP) will increase serum IGF-1 concentration in patients with OSA. METHODS: Patients with moderate to severe OSA were recruited from a sleep clinic and serum IGF-1 was measured before initiation of CPAP and at follow-up after 4.8 ± 2.5 months. Patients adherent to CPAP treatment (usage ≥ 4 h/night) were compared with those considered to be nonadherent (usage < 4 h/night). RESULTS: Complete data were obtained from 69 patients (86% male, age 56 ± 12 years, respiratory event index 43 ± 21 events/h, Epworth Sleepiness Scale score 12 ± 5). In those adherent to CPAP (n = 42), there was an increase in serum IGF-1 concentration with 21.1 (95% confidence interval [CI]: 13.1 to 29.2) μg/L compared to 4.7 (95% CI: -4.1 to 13.5) μg/L in the nonadherent group (n = 27) (P = .0083). In a linear multivariate model adjusting for sex, age, body mass index, respiratory event index, and mean oxygen saturation during the night recording, the change in serum IGF-1 concentration was significantly associated with adherence to CPAP treatment (adjusted β coefficient: 21.8, 95% CI: 10.2 to 33.4) and inversely associated with change in body mass index (adjusted β coefficient: -7.1, 95% CI: -11.3 to -3.0) and change in hemoglobin A1c (adjusted β coefficient: -1.8, 95% CI: -33 to -0.3). CONCLUSIONS: CPAP usage ≥ 4 h/night is associated with increased serum IGF-1 concentration in male patients with OSA.
STUDY OBJECTIVES:Obstructive sleep apnea (OSA) is a disease with metabolic and cardiovascular consequences and is associated with decreased serum concentrations of insulin-like growth factor-1 (IGF-1). The aim of this study was to investigate whether continuous positive airway pressure (CPAP) will increase serum IGF-1 concentration in patients with OSA. METHODS:Patients with moderate to severe OSA were recruited from a sleep clinic and serum IGF-1 was measured before initiation of CPAP and at follow-up after 4.8 ± 2.5 months. Patients adherent to CPAP treatment (usage ≥ 4 h/night) were compared with those considered to be nonadherent (usage < 4 h/night). RESULTS: Complete data were obtained from 69 patients (86% male, age 56 ± 12 years, respiratory event index 43 ± 21 events/h, Epworth Sleepiness Scale score 12 ± 5). In those adherent to CPAP (n = 42), there was an increase in serum IGF-1 concentration with 21.1 (95% confidence interval [CI]: 13.1 to 29.2) μg/L compared to 4.7 (95% CI: -4.1 to 13.5) μg/L in the nonadherent group (n = 27) (P = .0083). In a linear multivariate model adjusting for sex, age, body mass index, respiratory event index, and mean oxygen saturation during the night recording, the change in serum IGF-1 concentration was significantly associated with adherence to CPAP treatment (adjusted β coefficient: 21.8, 95% CI: 10.2 to 33.4) and inversely associated with change in body mass index (adjusted β coefficient: -7.1, 95% CI: -11.3 to -3.0) and change in hemoglobin A1c (adjusted β coefficient: -1.8, 95% CI: -33 to -0.3). CONCLUSIONS: CPAP usage ≥ 4 h/night is associated with increased serum IGF-1 concentration in male patients with OSA.
Authors: Aletta E Schutte; Elena Conti; Catharina Mc Mels; Wayne Smith; Ruan Kruger; Shani Botha; Lucio Gnessi; Massimo Volpe; Hugo W Huisman Journal: Eur J Prev Cardiol Date: 2016-07-22 Impact factor: 7.804
Authors: Imran H Iftikhar; Christopher W Valentine; Lia R A Bittencourt; Debbie L Cohen; Annette C Fedson; Thorarinn Gíslason; Thomas Penzel; Craig L Phillips; Lin Yu-sheng; Allan I Pack; Ulysses J Magalang Journal: J Hypertens Date: 2014-12 Impact factor: 4.844