Laura Brennan1,2, Andrew Siderowf3, Jonathan D Rubright4, Jacqueline Rick5, Nabila Dahodwala5, John E Duda2,5, Howard Hurtig5, Matthew Stern5, Sharon X Xie6, Lior Rennert6, Jason Karlawish7, Judy A Shea8, John Q Trojanowski5, Daniel Weintraub1,2,5. 1. Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. 2. Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA. 3. Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA. 4. American Institute of Certified Public Accountants, Ewing, New Jersey, USA. 5. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. 6. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. 7. Departments of Medical Ethics and Medicine, PENN-CMU Roybal Center on Behavioral Economics and Health, the LDI Center for Health Incentives, and Alzheimer's Disease Center. 8. Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Abstract
OBJECTIVE: The aim of this work was to describe the development and psychometric analysis of the Penn Parkinson's Daily Activities Questionnaire. The questionnaire is an item response theory-based tool for rating cognitive instrumental activities of daily living in PD. METHODS: Candidate items for the Penn Parkinson's Daily Activities Questionnaire were developed through literature review and focus groups of patients and knowledgeable informants. Item selection and calibration of item-response theory parameters were performed using responses from a cohort of PD patients and knowledgeable informants (n = 388). In independent cohorts of PD patients and knowledgeable informants, assessments of test-retest reliability (n = 50), and construct validity (n = 68) of the questionnaire were subsequently performed. Construct validity was assessed by correlating questionnaire scores with measures of motor function, cognition, an existing activities of daily living measure, and directly observed daily function. RESULTS: Fifty items were retained in the final questionnaire item bank. Items were excluded owing to redundancy, difficult reading level, and when item-response theory parameters could not be calculated. Test-retest reliability was high (intraclass correlation coefficient = 0.97; P < 0.001). The questionnaire correlated strongly with cognition (r = 0.68; P < 0.001) and directly observed daily function (r = 0.87; P < 0.001), but not with motor impairment (r = 0.08; P = 0.53). The questionnaire score accurately discriminated between PD patients with and without dementia (receiver operating characteristic curve = 0.91; 95% confidence interval: 0.85-0.97). CONCLUSIONS: The Penn Parkinson's Daily Activities Questionnaire shows strong evidence of reliability and validity. Item response theory-based psychometric analysis suggests that this questionnaire can discriminate across a range of daily functions.
OBJECTIVE: The aim of this work was to describe the development and psychometric analysis of the Penn Parkinson's Daily Activities Questionnaire. The questionnaire is an item response theory-based tool for rating cognitive instrumental activities of daily living in PD. METHODS: Candidate items for the Penn Parkinson's Daily Activities Questionnaire were developed through literature review and focus groups of patients and knowledgeable informants. Item selection and calibration of item-response theory parameters were performed using responses from a cohort of PDpatients and knowledgeable informants (n = 388). In independent cohorts of PDpatients and knowledgeable informants, assessments of test-retest reliability (n = 50), and construct validity (n = 68) of the questionnaire were subsequently performed. Construct validity was assessed by correlating questionnaire scores with measures of motor function, cognition, an existing activities of daily living measure, and directly observed daily function. RESULTS: Fifty items were retained in the final questionnaire item bank. Items were excluded owing to redundancy, difficult reading level, and when item-response theory parameters could not be calculated. Test-retest reliability was high (intraclass correlation coefficient = 0.97; P < 0.001). The questionnaire correlated strongly with cognition (r = 0.68; P < 0.001) and directly observed daily function (r = 0.87; P < 0.001), but not with motor impairment (r = 0.08; P = 0.53). The questionnaire score accurately discriminated between PDpatients with and without dementia (receiver operating characteristic curve = 0.91; 95% confidence interval: 0.85-0.97). CONCLUSIONS: The Penn Parkinson's Daily Activities Questionnaire shows strong evidence of reliability and validity. Item response theory-based psychometric analysis suggests that this questionnaire can discriminate across a range of daily functions.
Authors: S E Starkstein; L Sabe; G Petracca; E Chemerinski; G Kuzis; M Merello; R Leiguarda Journal: J Neurol Neurosurg Psychiatry Date: 1996-10 Impact factor: 10.154
Authors: Laura Brennan; Andrew Siderowf; Jonathan D Rubright; Jacqueline Rick; Nabila Dahodwala; John E Duda; Howard Hurtig; Matthew Stern; Sharon X Xie; Lior Rennert; Jason Karlawish; Judy A Shea; John Q Trojanowski; Daniel Weintraub Journal: Parkinsonism Relat Disord Date: 2016-02-21 Impact factor: 4.891
Authors: Benjamin L Deck; Jacqueline Rick; Sharon X Xie; Alice Chen-Plotkin; John E Duda; James F Morley; Lana M Chahine; Nabila Dahodwala; John Q Trojanowski; Daniel Weintraub Journal: J Parkinsons Dis Date: 2017 Impact factor: 5.568
Authors: Samantha K Holden; Luis D Medina; Brian Hoyt; Stefan H Sillau; Brian D Berman; Jennifer G Goldman; Daniel Weintraub; Benzi M Kluger Journal: Mov Disord Date: 2018-10-10 Impact factor: 10.338
Authors: Benjamin L Deck; Sharon X Xie; Gyujae Choi; Jacqueline Rick; Andrew Siderowf; Samuel Rudovsky; Alice Chen-Plotkin; John E Duda; James F Morley; Nabila Dahodwala; John Q Trojanowski; Daniel Weintraub Journal: Mov Disord Clin Pract Date: 2019-05-17
Authors: Ondrej Bezdicek; Josef Mana; Filip Růžička; Filip Havlik; Anna Fečíková; Tereza Uhrová; Evžen Růžička; Dušan Urgošík; Robert Jech Journal: Front Aging Neurosci Date: 2022-06-17 Impact factor: 5.702