Laura Brennan1, Andrew Siderowf2, Jonathan D Rubright3, Jacqueline Rick4, Nabila Dahodwala4, John E Duda5, Howard Hurtig4, Matthew Stern4, Sharon X Xie6, Lior Rennert7, Jason Karlawish8, Judy A Shea9, John Q Trojanowski4, Daniel Weintraub10. 1. Drexel Neurosciences Institute, Drexel University College of Medicine, 245 N. 15th St., 7102 NCB, Philadelphia, PA 19102, USA; Department of Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St., #330, Philadelphia, PA 19104, USA. 2. Avid Radiopharmaceuticals, 3711 Market St # 7, Philadelphia, PA 19104, USA. 3. National Board of Medical Examiners, 3750 Market Street, Philadelphia, PA 19104, USA. 4. Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA. 5. Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA; Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA. 6. Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 8th Floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA. 7. Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA. 8. Departments of Medical Ethics and Medicine, PENN-CMU Roybal Center on Behavioral Economics and Health, The LDI Center for Health Incentives, and Alzheimer's Disease Center, 3401 Market Street, Suite 320, Philadelphia, PA 19104, USA. 9. Department of Medicine, University of Pennsylvania School of Medicine, 3400 Civic Center Boulevard, Building 421, Philadelphia, PA 19104, USA. 10. Department of Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St., #330, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania School of Medicine, 330 S. 9th St., Philadelphia, PA 19107, USA; Philadelphia Veterans Affairs Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA. Electronic address: daniel.weintraub@uphs.upenn.edu.
Abstract
INTRODUCTION: To describe the psychometric properties of the Penn Parkinson's Daily Activities Questionnaire-15 (PDAQ-15), a 15-item measure of cognitive instrumental activities of daily living for Parkinson's disease (PD) patients derived from the original 50-item PDAQ. METHODS: PDAQ-15 items were chosen by expert consensus. Knowledgeable informants of PD participants (n = 161) completed the PDAQ-15. Knowledgeable informants were defined as an individual having regular contact with the PD participant. PD participants were assigned a diagnosis of normal cognition, mild cognitive impairment, or dementia based on expert consensus. RESULTS: PDAQ-15 scores correlated strongly with global cognition (Dementia Rating Scale-2, r = 0.71, p < 0.001) and a performance-based functional measure (Direct Assessment of Functional Status, r = 0.83; p < 0.001). PDAQ-15 scores accurately discriminated between non-demented PD participants (normal cognition/mild cognitive impairment) and PD with dementia (ROC curve area = 0.91), participants with and without any cognitive impairment (normal cognition versus mild cognitive impairment/dementia, ROC curve area = 0.85) and between participants with mild cognitive impairment and dementia (ROC curve area = 0.84). CONCLUSIONS: The PDAQ-15 shows good discriminant validity across cognitive stages, correlates highly with global cognitive performance, and appears suitable to assess daily cognitive functioning in PD.
INTRODUCTION: To describe the psychometric properties of the Penn Parkinson's Daily Activities Questionnaire-15 (PDAQ-15), a 15-item measure of cognitive instrumental activities of daily living for Parkinson's disease (PD) patients derived from the original 50-item PDAQ. METHODS:PDAQ-15 items were chosen by expert consensus. Knowledgeable informants of PDparticipants (n = 161) completed the PDAQ-15. Knowledgeable informants were defined as an individual having regular contact with the PDparticipant. PDparticipants were assigned a diagnosis of normal cognition, mild cognitive impairment, or dementia based on expert consensus. RESULTS:PDAQ-15 scores correlated strongly with global cognition (Dementia Rating Scale-2, r = 0.71, p < 0.001) and a performance-based functional measure (Direct Assessment of Functional Status, r = 0.83; p < 0.001). PDAQ-15 scores accurately discriminated between non-demented PDparticipants (normal cognition/mild cognitive impairment) and PD with dementia (ROC curve area = 0.91), participants with and without any cognitive impairment (normal cognition versus mild cognitive impairment/dementia, ROC curve area = 0.85) and between participants with mild cognitive impairment and dementia (ROC curve area = 0.84). CONCLUSIONS: The PDAQ-15 shows good discriminant validity across cognitive stages, correlates highly with global cognitive performance, and appears suitable to assess daily cognitive functioning in PD.
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