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Literature DB >> 26247005

The role of PET quantification in cardiovascular imaging.

Piotr Slomka¹, Daniel S Berman², Erick Alexanderson³, Guido Germano¹.

Abstract

Positron Emission Tomography (PET) has several clinical and research applications in cardiovascular imaging. Myocardial perfusion imaging with PET allows accurate global and regional measurements of myocardial perfusion, myocardial blood flow and function at stress and rest in one exam. Simultaneous assessment of function and perfusion by PET with quantitative software is currently the routine practice. Combination of ejection fraction reserve with perfusion information may improve the identification of severe disease. The myocardial viability can be estimated by quantitative comparison of fluorodeoxyglucose (18FDG) and rest perfusion imaging. The myocardial blood flow and coronary flow reserve measurements are becoming routinely included in the clinical assessment due to enhanced dynamic imaging capabilities of the latest PET/CT scanners. Absolute flow measurements allow evaluation of the coronary microvascular dysfunction and provide additional prognostic and diagnostic information for coronary disease. Standard quantitative approaches to compute myocardial blood flow from kinetic PET data in automated and rapid fashion have been developed for 13N-ammonia, 15O-water and 82Rb radiotracers. The agreement between software methods available for such analysis is excellent. Relative quantification of 82Rb PET myocardial perfusion, based on comparisons to normal databases, demonstrates high performance for the detection of obstructive coronary disease. New tracers, such as 18F-flurpiridaz may allow further improvements in the disease detection. Computerized analysis of perfusion at stress and rest reduces the variability of the assessment as compared to visual analysis. PET quantification can be enhanced by precise coregistration with CT angiography. In emerging clinical applications, the potential to identify vulnerable plaques by quantification of atherosclerotic plaque uptake of 18FDG and 18F-sodium fluoride tracers in carotids, aorta and coronary arteries has been demonstrated.

Entities: Chemical Disease Gene Species

Keywords: cardiac PET; cardiac function; coronary flow reserve; hybrid PET/CT; myocardial perfusion; myocardial perfusion flow; myocardial viability; quantification; vascular imaging; vulnerable plaque

Year: 2014 PMID： 26247005 PMCID： PMC4523308 DOI： 10.1007/s40336-014-0070-2

Source DB: PubMed Journal: Clin Transl Imaging ISSN： 2281-5872

60 in total

1. Clinical evaluation of a new concept: resting myocardial perfusion heterogeneity quantified by markovian analysis of PET identifies coronary microvascular dysfunction and early atherosclerosis in 1,034 subjects.

Authors: Nils P Johnson; K Lance Gould
Journal: J Nucl Med Date: 2005-09 Impact factor: 10.057

2. Quantification of myocardial blood flow with 82Rb positron emission tomography: clinical validation with 15O-water.

Authors: John O Prior; Gilles Allenbach; Ines Valenta; Marek Kosinski; Cyrill Burger; Francis R Verdun; Angelika Bischof Delaloye; Philipp A Kaufmann
Journal: Eur J Nucl Med Mol Imaging Date: 2012-03-08 Impact factor: 9.236

3. Validation of an evaluation routine for left ventricular volumes, ejection fraction and wall motion from gated cardiac FDG PET: a comparison with cardiac magnetic resonance imaging.

Authors: Wolfgang M Schaefer; Claudia S A Lipke; Bernd Nowak; Hans Juergen Kaiser; Arno Buecker; Gabriele A Krombach; Udalrich Buell; Harald P Kühl
Journal: Eur J Nucl Med Mol Imaging Date: 2003-02-15 Impact factor: 9.236

4. Comparison of clinical tools for measurements of regional stress and rest myocardial blood flow assessed with 13N-ammonia PET/CT.

Authors: Piotr J Slomka; Erick Alexanderson; Rodrigo Jácome; Moises Jiménez; Edgar Romero; Aloha Meave; Ludovic Le Meunier; Magnus Dalhbom; Daniel S Berman; Guido Germano; Heinrich Schelbert
Journal: J Nucl Med Date: 2012-01-06 Impact factor: 10.057

5. CCS/CAR/CANM/CNCS/CanSCMR joint position statement on advanced noninvasive cardiac imaging using positron emission tomography, magnetic resonance imaging and multidetector computed tomographic angiography in the diagnosis and evaluation of ischemic heart disease--executive summary.

Authors: R S B Beanlands; B J W Chow; A Dick; M G Friedrich; K Y Gulenchyn; M Kiess; H Leong-Poi; R M Miller; G Nichol; M Freeman; P Bogaty; G Honos; G Hudon; G Wisenberg; J Van Berkom; K Williams; K Yoshinaga; J Graham
Journal: Can J Cardiol Date: 2007-02 Impact factor: 5.223

6. Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF.

Authors: Sharmila Dorbala; Rory Hachamovitch; Zelmira Curillova; Deepak Thomas; Divya Vangala; Raymond Y Kwong; Marcelo F Di Carli
Journal: JACC Cardiovasc Imaging Date: 2009-07

7. Independent and incremental prognostic value of left ventricular ejection fraction determined by stress gated rubidium 82 PET imaging in patients with known or suspected coronary artery disease.

Authors: Kirkeith Lertsburapa; Alan W Ahlberg; Timothy M Bateman; Deborah Katten; Lyndy Volker; S James Cullom; Gary V Heller
Journal: J Nucl Cardiol Date: 2008-09-12 Impact factor: 5.952

8. Comparison of fully automated computer analysis and visual scoring for detection of coronary artery disease from myocardial perfusion SPECT in a large population.

Authors: Reza Arsanjani; Yuan Xu; Sean W Hayes; Mathews Fish; Mark Lemley; James Gerlach; Sharmila Dorbala; Daniel S Berman; Guido Germano; Piotr Slomka
Journal: J Nucl Med Date: 2013-01-11 Impact factor: 10.057

9. Positron emission tomography and recovery following revascularization (PARR-1): the importance of scar and the development of a prediction rule for the degree of recovery of left ventricular function.

Authors: Rob S B Beanlands; Terrence D Ruddy; Robert A deKemp; Robert M Iwanochko; Geoffrey Coates; Michael Freeman; Claude Nahmias; Paul Hendry; Robert J Burns; Andre Lamy; Lynda Mickleborough; William Kostuk; Ernest Fallen; Graham Nichol
Journal: J Am Coll Cardiol Date: 2002-11-20 Impact factor: 24.094

Review 10. Anatomy and physiology of coronary blood flow.

Authors: Heinrich R Schelbert
Journal: J Nucl Cardiol Date: 2010-08 Impact factor: 5.952

13 in total

1. Early post-STEMI PET, a judicious investment?

Authors: Riemer H J A Slart; Luis Eduardo Juarez-Orozco
Journal: J Nucl Cardiol Date: 2017-08-03 Impact factor: 5.952

2. Cardiac-gated parametric images from ⁸² Rb PET from dynamic frames and direct 4D reconstruction.

Authors: Mary Germino; Richard E Carson
Journal: Med Phys Date: 2017-12-30 Impact factor: 4.071

Review 3. Cardiovascular Imaging Techniques to Assess Microvascular Dysfunction.

Authors: Roshin C Mathew; Jamieson M Bourque; Michael Salerno; Christopher M Kramer
Journal: JACC Cardiovasc Imaging Date: 2019-10-11

Review 4. PET-Based Imaging of Ischemic Heart Disease.

Authors: Kevin Chen; Edward J Miller; Mehran M Sadeghi
Journal: PET Clin Date: 2019-02-01

Review 5. Coronary microvascular dysfunction in diabetes mellitus.

Authors: Aleksandar Kibel; Kristina Selthofer-Relatic; Ines Drenjancevic; Tatjana Bacun; Ivica Bosnjak; Dijana Kibel; Mario Gros
Journal: J Int Med Res Date: 2017-01-12 Impact factor: 1.671

6. Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM.

Authors: Brett W Sperry; Timothy M Bateman; Esma A Akin; Paco E Bravo; Wengen Chen; Vasken Dilsizian; Fabien Hyafil; Yiu Ming Khor; Robert J H Miller; Riemer H J A Slart; Piotr Slomka; Hein Verberne; Edward J Miller; Chi Liu
Journal: J Nucl Cardiol Date: 2022-07-21 Impact factor: 3.872