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Literature DB >> 26239992

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin.

Sandrine Marchand¹, Nicolas Grégoire², Julien Brillault², Isabelle Lamarche², Patrice Gobin³, William Couet⁴.

Abstract

The aim of this study was to determine the biopharmaceutical characteristics of tobramycin (TOB) after nebulization in rats. TOB was administered by intravenous (i.v.) bolus or intratracheal nebulization (3 mg · kg(-1)), and concentrations were determined in plasma and epithelial lining fluid (ELF) by liquid chromatography-tandem mass spectrometry. The ratio of the TOB concentration in ELF to the plasma area under the curve (AUC) was more than 200 times as high after NEB as after i.v. bolus administration, indicating that TOB nebulization offers a biopharmaceutical advantage over i.v. administration.

Entities: Chemical Species

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Year: 2015 PMID： 26239992 PMCID： PMC4576081 DOI： 10.1128/AAC.01647-15

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

1. Determination of tobramycin in serum using liquid chromatography-tandem mass spectrometry and comparison with a fluorescence polarisation assay.

Authors: Brian G Keevil; Stephen J Lockhart; Donald P Cooper
Journal: J Chromatogr B Analyt Technol Biomed Life Sci Date: 2003-09-05 Impact factor: 3.205

2. Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats.

Authors: Sandrine Marchand; Patrice Gobin; Julien Brillault; Sara Baptista; Christophe Adier; Jean-Christophe Olivier; Olivier Mimoz; William Couet
Journal: Antimicrob Agents Chemother Date: 2010-06-14 Impact factor: 5.191

3. Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections.

Authors: Shalini Yapa; Jian Li; Christopher J H Porter; Roger L Nation; Kashyap Patel; Michelle P McIntosh
Journal: Antimicrob Agents Chemother Date: 2013-08-05 Impact factor: 5.191

4. Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model.

Authors: Julien Brillault; Whocely Victor De Castro; William Couet
Journal: Antimicrob Agents Chemother Date: 2009-10-12 Impact factor: 5.191

5. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 2. Colistin.

Authors: Aline Vidal Lacerda Gontijo; Nicolas Grégoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand
Journal: Antimicrob Agents Chemother Date: 2014-05-05 Impact factor: 5.191

6. Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.

Authors: Aline Vidal Lacerda Gontijo; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand
Journal: Antimicrob Agents Chemother Date: 2014-05-05 Impact factor: 5.191

Review 7. Inhaled antibiotics beyond aminoglycosides, polymyxins and aztreonam: A systematic review.

Authors: Matthew E Falagas; Kyriakos K Trigkidis; Konstantinos Z Vardakas
Journal: Int J Antimicrob Agents Date: 2014-11-06 Impact factor: 5.283

8. P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model.

Authors: Julien Brillault; Whocely Victor De Castro; Thomas Harnois; Alain Kitzis; Jean-Christophe Olivier; William Couet
Journal: Antimicrob Agents Chemother Date: 2009-02-02 Impact factor: 5.191

8 in total

7 in total

1. Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.

Authors: Romain Carrez; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Julian Laroche; William Couet; Sandrine Marchand
Journal: Antimicrob Agents Chemother Date: 2019-05-24 Impact factor: 5.191

2. Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus.

Authors: Shachi Mehta; Vincent Aranzana-Climent; Blandine Rammaert; Nicolas Grégoire; Sandrine Marchand; William Couet; Julien M Buyck
Journal: Antimicrob Agents Chemother Date: 2019-06-24 Impact factor: 5.191

3. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam.

Authors: Sandrine Marchand; Nicolas Grégoire; Julien Brillault; Isabelle Lamarche; Patrice Gobin; William Couet
Journal: Antimicrob Agents Chemother Date: 2016-04-22 Impact factor: 5.191

4. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate.

Authors: Danilo Cesar Galindo Bedor; Sandrine Marchand; Isabelle Lamarche; Julian Laroche; Davi Pereira de Santana; William Couet
Journal: Antimicrob Agents Chemother Date: 2016-07-22 Impact factor: 5.191

5. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides.

Authors: Sandrine Marchand; Matthieu Boisson; Shachi Mehta; Christophe Adier; Olivier Mimoz; Nicolas Grégoire; William Couet
Journal: Antimicrob Agents Chemother Date: 2018-09-24 Impact factor: 5.191

Review 6. Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones.

Authors: Julien Brillault; Frédéric Tewes
Journal: Pharmaceutics Date: 2020-04-23 Impact factor: 6.321

7. Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions.

Authors: Tomás Sou; Fadi Soukarieh; Paul Williams; Michael J Stocks; Miguel Cámara; Christel A S Bergström
Journal: ACS Omega Date: 2020-09-22

7 in total