Literature DB >> 19822706

Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model.

Julien Brillault1, Whocely Victor De Castro, William Couet.   

Abstract

The transport characteristics of six fluoroquinolones (FQs) with various lipophilicities were compared in a Calu-3 cell model. For each FQ, an active polarized transport was observed in the direction of the apical side. However, the apparent permeability of FQs resulted from active transport and passive diffusion that were highly variable between compounds and mainly governed by lipophilicity. Therefore, active transport was predominant for compounds with relatively low lipophilicity but minor for FQs with higher lipophilicity.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19822706      PMCID： PMC2798514          DOI： 10.1128/AAC.00733-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Protonation equilibrium and lipophilicity of moxifloxacin.

Authors:  Marie-Hélène Langlois; Martine Montagut; Jean-Pierre Dubost; Jean Grellet; Marie-Claude Saux
Journal:  J Pharm Biomed Anal       Date:  2005-02-23       Impact factor: 3.935

2.  Transport characteristics of grepafloxacin and levofloxacin in the human intestinal cell line Caco-2.

Authors:  H Yamaguchi; I Yano; H Saito; K Inui
Journal:  Eur J Pharmacol       Date:  2001-11-23       Impact factor: 4.432

3.  Multidrug resistance-associated protein-1 functional activity in Calu-3 cells.

Authors:  K O Hamilton; E Topp; I Makagiansar; T Siahaan; M Yazdanian; K L Audus
Journal:  J Pharmacol Exp Ther       Date:  2001-09       Impact factor: 4.030

4.  P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers.

Authors:  Sibylle Endter; Ulrich Becker; Nicole Daum; Hanno Huwer; Claus-Michael Lehr; Mark Gumbleton; Carsten Ehrhardt
Journal:  Cell Tissue Res       Date:  2006-12-13       Impact factor: 5.249

Review 5.  Fluoroquinolone efflux mediated by ABC transporters.

Authors:  Ana I Alvarez; Miriam Pérez; Julio G Prieto; Antonio J Molina; Rebeca Real; Gracia Merino
Journal:  J Pharm Sci       Date:  2008-09       Impact factor: 3.534

6.  P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model.

Authors:  Julien Brillault; Whocely Victor De Castro; Thomas Harnois; Alain Kitzis; Jean-Christophe Olivier; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

7.  Transport characteristics of fexofenadine in the Caco-2 cell model.

Authors:  Niclas Petri; Christer Tannergren; David Rungstad; Hans Lennernäs
Journal:  Pharm Res       Date:  2004-08       Impact factor: 4.200

8.  Pharmacokinetics of pefloxacin in renal insufficiency.

Authors:  G Montay; C Jacquot; J Bariety; R Cunci
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

9.  Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.

Authors:  Matthew D Troutman; Dhiren R Thakker
Journal:  Pharm Res       Date:  2003-08       Impact factor: 4.200

10.  Efficacy of aerosol MP-376, a levofloxacin inhalation solution, in models of mouse lung infection due to Pseudomonas aeruginosa.

Authors:  Mojgan Sabet; Courtney E Miller; Thomas G Nolan; Kathy Senekeo-Effenberger; Michael N Dudley; David C Griffith
Journal:  Antimicrob Agents Chemother       Date:  2009-06-15       Impact factor: 5.191
View more
  14 in total

1.  Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats.

Authors:  Sandrine Marchand; Patrice Gobin; Julien Brillault; Sara Baptista; Christophe Adier; Jean-Christophe Olivier; Olivier Mimoz; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2010-06-14       Impact factor: 5.191

2.  Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.

Authors:  Romain Carrez; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Julian Laroche; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

Review 3.  Interethnic differences in pharmacokinetics of antibacterials.

Authors:  Danny Tsai; Janattul-Ain Jamal; Joshua S Davis; Jeffrey Lipman; Jason A Roberts
Journal:  Clin Pharmacokinet       Date:  2015-03       Impact factor: 6.447

4.  Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam.

Authors:  Sandrine Marchand; Nicolas Grégoire; Julien Brillault; Isabelle Lamarche; Patrice Gobin; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

5.  In Vitro Mechanistic Study of the Distribution of Lascufloxacin into Epithelial Lining Fluid.

Authors:  Kouhei Ohya; Junichi Takano; Shigeru Manita
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

6.  Simultaneous Semimechanistic Population Analyses of Levofloxacin in Plasma, Lung, and Prostate To Describe the Influence of Efflux Transporters on Drug Distribution following Intravenous and Intratracheal Administration.

Authors:  Estevan Sonego Zimmermann; João Victor Laureano; Camila Neris Dos Santos; Stephan Schmidt; Chakradhar V Lagishetty; Whocely Victor de Castro; Teresa Dalla Costa
Journal:  Antimicrob Agents Chemother       Date:  2015-11-30       Impact factor: 5.191

7.  Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.

Authors:  Aline Vidal Lacerda Gontijo; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2014-05-05       Impact factor: 5.191

8.  Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model.

Authors:  Mayur K Ladumor; Jashvant D Unadkat
Journal:  Drug Metab Dispos       Date:  2022-03-04       Impact factor: 3.579

9.  Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate.

Authors:  Danilo Cesar Galindo Bedor; Sandrine Marchand; Isabelle Lamarche; Julian Laroche; Davi Pereira de Santana; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

10.  Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin.

Authors:  Sandrine Marchand; Nicolas Grégoire; Julien Brillault; Isabelle Lamarche; Patrice Gobin; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.