Literature DB >> 30082284

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 6. Aminoglycosides.

Sandrine Marchand1,2,3, Matthieu Boisson4,2,5, Shachi Mehta2, Christophe Adier3, Olivier Mimoz4,2,6, Nicolas Grégoire4,2, William Couet4,2,3.   

Abstract

Amikacin and gentamicin pharmacokinetic behaviors after nebulization were determined by comparing plasma and pulmonary epithelial lining fluid (ELF) concentrations in rats after intratracheal and intravenous administrations. ELF areas under concentration-time curve were 874 and 162 times higher after nebulization than after intravenous administration for amikacin and gentamicin, respectively. Even if both molecules appear to be good candidates for nebulization, these results demonstrate a much higher targeting advantage of nebulization for amikacin than for gentamicin.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  aminoglycosides; biopharmaceutics; nebulization

Mesh：

Substances：

Year:  2018        PMID： 30082284      PMCID： PMC6153828          DOI： 10.1128/AAC.01261-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats.

Authors:  Sandrine Marchand; Patrice Gobin; Julien Brillault; Sara Baptista; Christophe Adier; Jean-Christophe Olivier; Olivier Mimoz; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2010-06-14       Impact factor: 5.191

2.  LC/MS/MS measurement of gentamicin in bovine plasma, urine, milk, and biopsy samples taken from kidneys of standing animals.

Authors:  David N Heller; James O Peggins; Cristina B Nochetto; Michelle L Smith; O Alberto Chiesa; Keesla Moulton
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2005-07-05       Impact factor: 3.205

3.  Development of a new pre- and post-processing tool (SADAPT-TRAN) for nonlinear mixed-effects modeling in S-ADAPT.

Authors:  Jurgen Bernd Bulitta; Ayhan Bingölbali; Beom Soo Shin; Cornelia Barbara Landersdorfer
Journal:  AAPS J       Date:  2011-03-03       Impact factor: 4.009

4.  Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam.

Authors:  Sandrine Marchand; Nicolas Grégoire; Julien Brillault; Isabelle Lamarche; Patrice Gobin; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

5.  Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration.

Authors:  Shalini Yapa; Jian Li; Kashyap Patel; John W Wilson; Michael J Dooley; Johnson George; Denise Clark; Susan Poole; Elyssa Williams; Christopher J H Porter; Roger L Nation; Michelle P McIntosh
Journal:  Antimicrob Agents Chemother       Date:  2014-02-18       Impact factor: 5.191

6.  Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 2. Colistin.

Authors:  Aline Vidal Lacerda Gontijo; Nicolas Grégoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2014-05-05       Impact factor: 5.191

7.  Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.

Authors:  Aline Vidal Lacerda Gontijo; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Patrice Gobin; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2014-05-05       Impact factor: 5.191

8.  Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin.

Authors:  Sandrine Marchand; Nicolas Grégoire; Julien Brillault; Isabelle Lamarche; Patrice Gobin; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2015-08-03       Impact factor: 5.191

9.  Global survey on nebulization of antimicrobial agents in mechanically ventilated patients: a call for international guidelines.

Authors:  C Solé-Lleonart; J A Roberts; J Chastre; G Poulakou; L B Palmer; S Blot; T Felton; M Bassetti; C-E Luyt; J M Pereira; J Riera; T Welte; H Qiu; J-J Rouby; J Rello
Journal:  Clin Microbiol Infect       Date:  2015-12-23       Impact factor: 8.067
  9 in total
  3 in total

1.  Pulmonary Pharmacokinetics of Oseltamivir Carboxylate in Rats after Nebulization or Intravenous Administration of Its Prodrug, Oseltamivir Phosphate.

Authors:  Romain Carrez; Julien Brillault; Nicolas Grégoire; Isabelle Lamarche; Julian Laroche; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2019-05-24       Impact factor: 5.191

2.  Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus.

Authors:  Shachi Mehta; Vincent Aranzana-Climent; Blandine Rammaert; Nicolas Grégoire; Sandrine Marchand; William Couet; Julien M Buyck
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

3.  Optimized Extraction of Amikacin from Murine Whole Blood.

Authors:  Roccaldo Sardella; Styliani Xiroudaki; Laura Mercolini; Samuele Sabbatini; Claudia Monari; Stefano Perito; Federica Ianni; Anna Vecchiarelli; Stefano Giovagnoli
Journal:  Molecules       Date:  2021-01-27       Impact factor: 4.411
  3 in total

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