Literature DB >> 26239912

Regenerative cellular therapies for neurologic diseases.

Michael Levy1, Nicholas Boulis2, Mahendra Rao3, Clive N Svendsen4.   

Abstract

The promise of stem cell regeneration has been the hope of many neurologic patients with permanent damage to the central nervous system. There are hundreds of stem cell trials worldwide intending to test the regenerative capacity of stem cells in various neurological conditions from Parkinson's disease to multiple sclerosis. Although no stem cell therapy is clinically approved for use in any human disease indication, patients are seeking out trials and asking clinicians for guidance. This review summarizes the current state of regenerative stem cell transplantation divided into seven conditions for which trials are currently active: demyelinating diseases/spinal cord injury, amyotrophic lateral sclerosis, stroke, Parkinson's disease, Huntington's disease, macular degeneration and peripheral nerve diseases. This article is part of a Special Issue entitled SI: PSC and the brain.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Neurologic disease; Regeneration; Stem cell

Mesh：

Year:  2015        PMID： 26239912      PMCID： PMC4733583          DOI： 10.1016/j.brainres.2015.06.053

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  68 in total

Review 1.  Stem cells as a potential treatment of neurological disorders.

Authors:  Yu-Tzu Tai; Clive N Svendsen
Journal:  Curr Opin Pharmacol       Date:  2004-02       Impact factor: 5.547

Review 2.  Amyotrophic lateral sclerosis: an update on recent genetic insights.

Authors:  Yohei Iguchi; Masahisa Katsuno; Kensuke Ikenaka; Shinsuke Ishigaki; Gen Sobue
Journal:  J Neurol       Date:  2013-10-02       Impact factor: 4.849

Review 3.  Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.

Authors:  Rajesh Ambasudhan; Nima Dolatabadi; Anthony Nutter; Eliezer Masliah; Scott R Mckercher; Stuart A Lipton
Journal:  J Comp Neurol       Date:  2014-05-07       Impact factor: 3.215

4.  Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Authors:  Abdellatif Benraiss; Michael J Toner; Qiwu Xu; Elodie Bruel-Jungerman; Eloise H Rogers; Fushun Wang; Aris N Economides; Beverly L Davidson; Ryoichiro Kageyama; Maiken Nedergaard; Steven A Goldman
Journal:  Cell Stem Cell       Date:  2013-06-06       Impact factor: 24.633

5.  Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial.

Authors:  Kameshwar Prasad; Alka Sharma; Ajay Garg; Sujata Mohanty; Shinjini Bhatnagar; Sharat Johri; Kunwar Karni Singh; Velu Nair; Ravi Shankar Sarkar; Sankar Prasad Gorthi; Kaukab Maqbool Hassan; Sudesh Prabhakar; Neelam Marwaha; Niranjan Khandelwal; Usha Kant Misra; Jayantee Kalita; Soniya Nityanand
Journal:  Stroke       Date:  2014-11-06       Impact factor: 7.914

6.  Transplanted neural stem cells promote axonal regeneration through chronically denervated peripheral nerves.

Authors:  Walter Heine; Katherine Conant; John W Griffin; Ahmet Höke
Journal:  Exp Neurol       Date:  2004-10       Impact factor: 5.330

Review 7.  Development of human embryonic stem cell therapies for age-related macular degeneration.

Authors:  Amanda-Jayne F Carr; Matthew J K Smart; Conor M Ramsden; Michael B Powner; Lyndon da Cruz; Peter J Coffey
Journal:  Trends Neurosci       Date:  2013-04-17       Impact factor: 13.837

8.  Human neural stem cell transplants improve motor function in a rat model of Huntington's disease.

Authors:  Jodi L McBride; Soshana P Behrstock; Er-Yun Chen; Rebekah J Jakel; Irwin Siegel; Clive N Svendsen; Jeffrey H Kordower
Journal:  J Comp Neurol       Date:  2004-07-19       Impact factor: 3.215

9.  A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease.

Authors:  C Warren Olanow; Christopher G Goetz; Jeffrey H Kordower; A Jon Stoessl; Vesna Sossi; Mitchell F Brin; Kathleen M Shannon; G Michael Nauert; Daniel P Perl; James Godbold; Thomas B Freeman
Journal:  Ann Neurol       Date:  2003-09       Impact factor: 10.422

10.  The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease.

Authors:  Roger A Barker; Sarah L Mason; Timothy P Harrower; Rachel A Swain; Aileen K Ho; Barbara J Sahakian; Raj Mathur; Sohier Elneil; Steven Thornton; Carrie Hurrelbrink; Richard J Armstrong; Pam Tyers; Emma Smith; Adrian Carpenter; Paola Piccini; Yen F Tai; David J Brooks; Nicola Pavese; Colin Watts; John D Pickard; Anne E Rosser; Stephen B Dunnett
Journal:  J Neurol Neurosurg Psychiatry       Date:  2013-01-23       Impact factor: 10.154
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  14 in total

Review 1.  What's new in neuromyelitis optica? A short review for the clinical neurologist.

Authors:  Daniel Whittam; Martin Wilson; Shahd Hamid; Geoff Keir; Maneesh Bhojak; Anu Jacob
Journal:  J Neurol       Date:  2017-03-13       Impact factor: 4.849

Review 2.  Stem Cell Therapy for the Central Nervous System in Lysosomal Storage Diseases.

Authors:  Faez Siddiqi; John H Wolfe
Journal:  Hum Gene Ther       Date:  2016-07-13       Impact factor: 5.695

3.  Treatment of Neuromyelitis Optica Spectrum Disorder: Acute, Preventive, and Symptomatic.

Authors:  Remi A Kessler; Maureen A Mealy; Michael Levy
Journal:  Curr Treat Options Neurol       Date:  2016-01       Impact factor: 3.598

Review 4.  Reprogramming of Keratinocytes as Donor or Target Cells Holds Great Promise for Cell Therapy and Regenerative Medicine.

Authors:  Yuehou Zhang; Wenzhi Hu; Kui Ma; Cuiping Zhang; Xiaobing Fu
Journal:  Stem Cell Rev Rep       Date:  2019-10       Impact factor: 5.739

Review 5.  Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA.

Authors:  Paul J Kemp; David J Rushton; Polina L Yarova; Christian Schnell; Charlene Geater; Jane M Hancock; Annalena Wieland; Alis Hughes; Luned Badder; Emma Cope; Daniela Riccardi; Andrew D Randall; Jonathan T Brown; Nicholas D Allen; Vsevolod Telezhkin
Journal:  J Physiol       Date:  2016-11-15       Impact factor: 5.182

6.  Enhanced neuroprotective efficacy of bone marrow mesenchymal stem cells co-overexpressing BDNF and VEGF in a rat model of cardiac arrest-induced global cerebral ischemia.

Authors:  Lili Zhou; Qingming Lin; Peng Wang; Lan Yao; Kahong Leong; Zhiqun Tan; Zitong Huang
Journal:  Cell Death Dis       Date:  2017-05-11       Impact factor: 8.469

7.  Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies.

Authors:  Natalie R S Goldberg; Samuel E Marsh; Joseph Ochaba; Brandon C Shelley; Hayk Davtyan; Leslie M Thompson; Joan S Steffan; Clive N Svendsen; Mathew Blurton-Jones
Journal:  Stem Cells Transl Med       Date:  2017-02-22       Impact factor: 6.940

Review 8.  Efficacy and safety of rituximab in neuromyelitis optica: Review of evidence.

Authors:  Masoud Etemadifar; Mehri Salari; Omid Mirmosayyeb; Mehdi Serati; Roham Nikkhah; Mozhde Askari; Emad Fayyazi
Journal:  J Res Med Sci       Date:  2017-02-16       Impact factor: 1.852

9.  Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice.

Authors:  Anita Lakatos; Natalie R S Goldberg; Mathew Blurton-Jones
Journal:  Acta Neuropathol Commun       Date:  2017-03-10       Impact factor: 7.801

Review 10.  3-D Bioprinting of Neural Tissue for Applications in Cell Therapy and Drug Screening.

Authors:  Michaela Thomas; Stephanie M Willerth
Journal:  Front Bioeng Biotechnol       Date:  2017-11-17
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