Literature DB >> 23746982

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Abdellatif Benraiss1, Michael J Toner, Qiwu Xu, Elodie Bruel-Jungerman, Eloise H Rogers, Fushun Wang, Aris N Economides, Beverly L Davidson, Ryoichiro Kageyama, Maiken Nedergaard, Steven A Goldman.   

Abstract

Huntington's disease (HD) is a neurodegenerative disease characterized in part by the loss of striatopallidal medium spiny projection neurons (MSNs). Expression of BDNF and noggin via intracerebroventricular (ICV) delivery in an adenoviral vector triggers the addition of new neurons to the neostriatum. In this study, we found that a single ICV injection of the adeno-associated viruses AAV4-BDNF and AAV4-noggin triggered the sustained recruitment of new MSNs in both wild-type and R6/2 mice, a model of HD. Mice treated with AAV4-BDNF/noggin or with BDNF and noggin proteins actively recruited subependymal progenitor cells to form new MSNs that matured and achieved circuit integration. Importantly, the AAV4-BDNF/noggin-treated R6/2 mice showed delayed deterioration of motor function and substantially increased survival. In addition, squirrel monkeys given ICV injections of adenoviral BDNF/noggin showed similar addition of striatal neurons. Induced neuronal addition may therefore represent a promising avenue for disease amelioration in HD.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23746982      PMCID： PMC4051319          DOI： 10.1016/j.stem.2013.04.014

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  41 in total

1.  High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain.

Authors:  H M Keyoung; N S Roy; A Benraiss; A Louissaint; A Suzuki; M Hashimoto; W K Rashbaum; H Okano; S A Goldman
Journal:  Nat Biotechnol       Date:  2001-09       Impact factor: 54.908

2.  Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice.

Authors:  G J Klapstein; R S Fisher; H Zanjani; C Cepeda; E S Jokel; M F Chesselet; M S Levine
Journal:  J Neurophysiol       Date:  2001-12       Impact factor: 2.714

3.  Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain.

Authors:  A Benraiss; E Chmielnicki; K Lerner; D Roh; S A Goldman
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

Review 4.  Cellular therapy and induced neuronal replacement for Huntington's disease.

Authors:  Abdellatif Benraiss; Steven A Goldman
Journal:  Neurotherapeutics       Date:  2011-10       Impact factor: 7.620

5.  Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease.

Authors:  M Turmaine; A Raza; A Mahal; L Mangiarini; G P Bates; S W Davies
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

6.  Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients.

Authors:  Stephenie Paine-Saunders; Beth L Viviano; Aris N Economides; Scott Saunders
Journal:  J Biol Chem       Date:  2001-11-12       Impact factor: 5.157

7.  Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression.

Authors:  Y Dai; E M Schwarz; D Gu; W W Zhang; N Sarvetnick; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

8.  A fully humanized transgenic mouse model of Huntington disease.

Authors:  Amber L Southwell; Simon C Warby; Jeffrey B Carroll; Crystal N Doty; Niels H Skotte; Weining Zhang; Erika B Villanueva; Vlad Kovalik; Yuanyun Xie; Mahmoud A Pouladi; Jennifer A Collins; X William Yang; Sonia Franciosi; Michael R Hayden
Journal:  Hum Mol Genet       Date:  2012-09-21       Impact factor: 6.150

9.  A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.

Authors:  Libo Yu-Taeger; Elisabeth Petrasch-Parwez; Alexander P Osmand; Adriana Redensek; Silke Metzger; Laura E Clemens; Larry Park; David Howland; Carsten Calaminus; Xiaofeng Gu; Bernd Pichler; X William Yang; Olaf Riess; Huu Phuc Nguyen
Journal:  J Neurosci       Date:  2012-10-31       Impact factor: 6.167

10.  Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

Authors:  B L Davidson; C S Stein; J A Heth; I Martins; R M Kotin; T A Derksen; J Zabner; A Ghodsi; J A Chiorini
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205
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  27 in total

1.  Increased Olfactory Bulb BDNF Expression Does Not Rescue Deficits in Olfactory Neurogenesis in the Huntington's Disease R6/2 Mouse.

Authors:  Shamayra Smail; Dalbir Bahga; Brittnee McDole; Kathleen Guthrie
Journal:  Chem Senses       Date:  2016-01-18       Impact factor: 3.160

2.  Human-derived neural progenitors functionally replace astrocytes in adult mice.

Authors:  Hong Chen; Kun Qian; Wei Chen; Baoyang Hu; Lisle W Blackbourn; Zhongwei Du; Lixiang Ma; Huisheng Liu; Karla M Knobel; Melvin Ayala; Su-Chun Zhang
Journal:  J Clin Invest       Date:  2015-02-02       Impact factor: 14.808

Review 3.  In vivo reprogramming for tissue repair.

Authors:  Christophe Heinrich; Francesca M Spagnoli; Benedikt Berninger
Journal:  Nat Cell Biol       Date:  2015-03       Impact factor: 28.824

Review 4.  Prospects for engineering neurons from local neocortical cell populations as cell-mediated therapy for neurological disorders.

Authors:  Stanley Bazarek; Daniel A Peterson
Journal:  J Comp Neurol       Date:  2014-05-13       Impact factor: 3.215

Review 5.  Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Authors:  Ira J Fox; George Q Daley; Steven A Goldman; Johnny Huard; Timothy J Kamp; Massimo Trucco
Journal:  Science       Date:  2014-08-22       Impact factor: 47.728

Review 6.  Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease.

Authors:  Abigail Mariga; Mariela Mitre; Moses V Chao
Journal:  Neurobiol Dis       Date:  2016-03-22       Impact factor: 5.996

Review 7.  Adeno-associated virus-mediated cancer gene therapy: current status.

Authors:  Jingfeng Luo; Yuxuan Luo; Jihong Sun; Yurong Zhou; Yajing Zhang; Xiaoming Yang
Journal:  Cancer Lett       Date:  2014-11-10       Impact factor: 8.679

8.  Dopaminergic innervation of the human subventricular zone: a comparison between Huntington's chorea and Parkinson's disease.

Authors:  Martin Parent; C Bédard; E Pourcher
Journal:  Am J Neurodegener Dis       Date:  2013-09-18

Review 9.  Regenerative cellular therapies for neurologic diseases.

Authors:  Michael Levy; Nicholas Boulis; Mahendra Rao; Clive N Svendsen
Journal:  Brain Res       Date:  2015-07-31       Impact factor: 3.252

10.  Transplanted neural progenitors bridge gaps to benefit cord-injured monkeys.

Authors:  Steven A Goldman
Journal:  Nat Med       Date:  2018-04-10       Impact factor: 53.440
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