Michael F Canarie1, Suzanne Barry, Christopher L Carroll, Amanda Hassinger, Sarah Kandil, Simon Li, Matthew Pinto, Stacey L Valentine, E Vincent S Faustino. 1. 1Department of Pediatrics, Yale University School of Medicine, New Haven, CT. 2Department of Pediatric Critical Care, Nemours/AI duPont Hospital for Children, Wilmington, DE. 3Department of Pediatrics, Connecticut Children's Medical Center, Hartford, CT. 4Department of Pediatrics, Women and Children's Hospital of Buffalo, Buffalo, NY. 5Division of Pediatric Critical Care Medicine, Department of Pediatrics, Maria Fareri Children's Hospital, Valhalla, NY. 6Department of Pediatrics, University of Massachusetts Memorial Medical Center, Worcester, MA. 7Division of Critical Care, Department of Anesthesia, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA.
Abstract
OBJECTIVE: Delayed enteral nutrition, defined as enteral nutrition started 48 hours or more after admission to the PICU, is associated with an inability to achieve full enteral nutrition and worse outcomes in critically ill children. We reviewed nutritional practices in six medical-surgical PICUs and determined risk factors associated with delayed enteral nutrition in critically ill children. DESIGN: Retrospective cross-sectional study using medical records as source of data. SETTING: Six medical-surgical PICUs in northeastern United States. PATIENTS: Children less than 21 years old admitted to the PICU for 72 hours or more excluding those awaiting or recovering from abdominal surgery. MEASUREMENTS AND MAIN RESULTS: A total of 444 children with a median age of 4.0 years were included in the study. Enteral nutrition was started at a median time of 20 hours after admission to the PICU. There was no significant difference in time to start enteral nutrition among the PICUs. Of those included, 88 children (19.8%) had delayed enteral nutrition. Risk factors associated with delayed enteral nutrition were noninvasive (odds ratio, 3.37; 95% CI, 1.69-6.72) and invasive positive-pressure ventilation (odds ratio, 2.06; 95% CI, 1.15-3.69), severity of illness (odds ratio for every 0.1 increase in pediatric index of mortality 2 score, 1.39; 95% CI, 1.14-1.71), procedures (odds ratio, 3.33; 95% CI, 1.67-6.64), and gastrointestinal disturbances (odds ratio, 2.05; 95% CI, 1.14-3.68) within 48 hours after admission to the PICU. Delayed enteral nutrition was associated with failure to reach full enteral nutrition while in the PICU (odds ratio, 4.09; 95% CI, 1.97-8.53). Nutrition consults were obtained in less than half of the cases, and none of the PICUs used tools to assure the adequacy of energy and protein nutrition. CONCLUSIONS: Institutions in this study initiated enteral nutrition for a high percentage of patients by 48 hours of admission. Noninvasive positive-pressure ventilation was most strongly associated with delay enteral nutrition. A better understanding of these risk factors and assessments of nutritional requirements should be explored in future prospective studies.
OBJECTIVE: Delayed enteral nutrition, defined as enteral nutrition started 48 hours or more after admission to the PICU, is associated with an inability to achieve full enteral nutrition and worse outcomes in critically ill children. We reviewed nutritional practices in six medical-surgical PICUs and determined risk factors associated with delayed enteral nutrition in critically ill children. DESIGN: Retrospective cross-sectional study using medical records as source of data. SETTING: Six medical-surgical PICUs in northeastern United States. PATIENTS: Children less than 21 years old admitted to the PICU for 72 hours or more excluding those awaiting or recovering from abdominal surgery. MEASUREMENTS AND MAIN RESULTS: A total of 444 children with a median age of 4.0 years were included in the study. Enteral nutrition was started at a median time of 20 hours after admission to the PICU. There was no significant difference in time to start enteral nutrition among the PICUs. Of those included, 88 children (19.8%) had delayed enteral nutrition. Risk factors associated with delayed enteral nutrition were noninvasive (odds ratio, 3.37; 95% CI, 1.69-6.72) and invasive positive-pressure ventilation (odds ratio, 2.06; 95% CI, 1.15-3.69), severity of illness (odds ratio for every 0.1 increase in pediatric index of mortality 2 score, 1.39; 95% CI, 1.14-1.71), procedures (odds ratio, 3.33; 95% CI, 1.67-6.64), and gastrointestinal disturbances (odds ratio, 2.05; 95% CI, 1.14-3.68) within 48 hours after admission to the PICU. Delayed enteral nutrition was associated with failure to reach full enteral nutrition while in the PICU (odds ratio, 4.09; 95% CI, 1.97-8.53). Nutrition consults were obtained in less than half of the cases, and none of the PICUs used tools to assure the adequacy of energy and protein nutrition. CONCLUSIONS: Institutions in this study initiated enteral nutrition for a high percentage of patients by 48 hours of admission. Noninvasive positive-pressure ventilation was most strongly associated with delay enteral nutrition. A better understanding of these risk factors and assessments of nutritional requirements should be explored in future prospective studies.
Authors: Amanda Y Leong; Kristina R Cartwright; Gonzalo Garcia Guerra; Ari R Joffe; Vera C Mazurak; Bodil M K Larsen Journal: Pediatr Crit Care Med Date: 2014-02 Impact factor: 3.624
Authors: Theresa A Mikhailov; Evelyn M Kuhn; Jennifer Manzi; Melissa Christensen; Maureen Collins; Ann-Marie Brown; Ronald Dechert; Matthew C Scanlon; Martin K Wakeham; Praveen S Goday Journal: JPEN J Parenter Enteral Nutr Date: 2014-01-08 Impact factor: 4.016
Authors: Edward Vincent S Faustino; Sheila Hanson; Philip C Spinella; Marisa Tucci; Sarah H O'Brien; Antonio Rodriguez Nunez; Michael Yung; Edward Truemper; Li Qin; Simon Li; Kimberly Marohn; Adrienne G Randolph Journal: Crit Care Med Date: 2014-05 Impact factor: 7.598
Authors: Jessie M Hulst; Koen F Joosten; Dick Tibboel; Johannes B van Goudoever Journal: Curr Opin Clin Nutr Metab Care Date: 2006-05 Impact factor: 4.294
Authors: Monica S Vavilala; Mary A Kernic; Jin Wang; Nithya Kannan; Richard B Mink; Mark S Wainwright; Jonathan I Groner; Michael J Bell; Christopher C Giza; Douglas F Zatzick; Richard G Ellenbogen; Linda Ng Boyle; Pamela H Mitchell; Frederick P Rivara Journal: Crit Care Med Date: 2014-10 Impact factor: 7.598
Authors: Nilesh M Mehta; Lori J Bechard; Naomi Cahill; Miao Wang; Andrew Day; Christopher P Duggan; Daren K Heyland Journal: Crit Care Med Date: 2012-07 Impact factor: 7.598
Authors: Christine M Hardy Framson; Neal S LeLeiko; Gerard E Dallal; Ronenn Roubenoff; Linda K Snelling; Johanna T Dwyer Journal: Pediatr Crit Care Med Date: 2007-05 Impact factor: 3.624
Authors: Vijay Srinivasan; Natalie R Hasbani; Nilesh M Mehta; Sharon Y Irving; Sarah B Kandil; H Christine Allen; Katri V Typpo; Natalie Z Cvijanovich; E Vincent S Faustino; David Wypij; Michael S D Agus; Vinay M Nadkarni Journal: Pediatr Crit Care Med Date: 2020-03 Impact factor: 3.624
Authors: Lyvonne N Tume; Frederic V Valla; Koen Joosten; Corinne Jotterand Chaparro; Lynne Latten; Luise V Marino; Isobel Macleod; Clémence Moullet; Nazima Pathan; Shancy Rooze; Joost van Rosmalen; Sascha C A T Verbruggen Journal: Intensive Care Med Date: 2020-02-20 Impact factor: 17.440
Authors: Tomasz Nabialek; Lyvonne N Tume; Eloise Cercueil; Claire Morice; Lionel Bouvet; Florent Baudin; Frederic V Valla Journal: Front Pediatr Date: 2022-05-11 Impact factor: 3.569