Edward Vincent S Faustino1, Sheila Hanson, Philip C Spinella, Marisa Tucci, Sarah H O'Brien, Antonio Rodriguez Nunez, Michael Yung, Edward Truemper, Li Qin, Simon Li, Kimberly Marohn, Adrienne G Randolph. 1. 1Department of Pediatrics, Yale School of Medicine, New Haven, CT. 2Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, WI. 3Department of Pediatrics, Washington University at St. Louis School of Medicine, St. Louis, MO. 4Department of Pediatrics, CHU Sainte-Justine University of Montreal, Montreal, QC, Canada. 5Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH. 6Pediatric Intensive Care Unit, University of Santiago de Compostela, Santiago de Compostela, Spain. 7Pediatric Intensive Care Unit, Women's and Children's Hospital, Adelaide, South Australia, Australia. 8Department of Pediatrics, Children's Hospital and Medical Center, Omaha, NE. 9Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT. 10Department of Pediatrics, New York Medical College Maria Fareri Children's Hospital, Valhalla, NY. 11Department of Anesthesia, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA.
Abstract
OBJECTIVES: Although critically ill children are at increased risk for developing deep venous thrombosis, there are few pediatric studies establishing the prevalence of thrombosis or the efficacy of thromboprophylaxis. We tested the hypothesis that thromboprophylaxis is infrequently used in critically ill children even for those in whom it is indicated. DESIGN: Prospective multinational cross-sectional study over four study dates in 2012. SETTING: Fifty-nine PICUs in Australia, Canada, New Zealand, Portugal, Singapore, Spain, and the United States. PATIENTS: All patients less than 18 years old in the PICU during the study dates and times were included in the study, unless the patients were 1) boarding in the unit waiting for a bed outside the PICU or 2) receiving therapeutic anticoagulation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 2,484 children in the study, 2,159 (86.9%) had greater than or equal to 1 risk factor for thrombosis. Only 308 children (12.4%) were receiving pharmacologic thromboprophylaxis (e.g., aspirin, low-molecular-weight heparin, or unfractionated heparin). Of 430 children indicated to receive pharmacologic thromboprophylaxis based on consensus recommendations, only 149 (34.7%) were receiving it. Mechanical thromboprophylaxis was used in 156 of 655 children (23.8%) 8 years old or older, the youngest age for that device. Using nonlinear mixed effects model, presence of cyanotic congenital heart disease (odds ratio, 7.35; p < 0.001) and spinal cord injury (odds ratio, 8.85; p = 0.008) strongly predicted the use of pharmacologic and mechanical thromboprophylaxis, respectively. CONCLUSIONS: Thromboprophylaxis is infrequently used in critically ill children. This is true even for children at high risk of thrombosis where consensus guidelines recommend pharmacologic thromboprophylaxis.
OBJECTIVES: Although critically ill children are at increased risk for developing deep venous thrombosis, there are few pediatric studies establishing the prevalence of thrombosis or the efficacy of thromboprophylaxis. We tested the hypothesis that thromboprophylaxis is infrequently used in critically ill children even for those in whom it is indicated. DESIGN: Prospective multinational cross-sectional study over four study dates in 2012. SETTING: Fifty-nine PICUs in Australia, Canada, New Zealand, Portugal, Singapore, Spain, and the United States. PATIENTS: All patients less than 18 years old in the PICU during the study dates and times were included in the study, unless the patients were 1) boarding in the unit waiting for a bed outside the PICU or 2) receiving therapeutic anticoagulation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 2,484 children in the study, 2,159 (86.9%) had greater than or equal to 1 risk factor for thrombosis. Only 308 children (12.4%) were receiving pharmacologic thromboprophylaxis (e.g., aspirin, low-molecular-weight heparin, or unfractionated heparin). Of 430 children indicated to receive pharmacologic thromboprophylaxis based on consensus recommendations, only 149 (34.7%) were receiving it. Mechanical thromboprophylaxis was used in 156 of 655 children (23.8%) 8 years old or older, the youngest age for that device. Using nonlinear mixed effects model, presence of cyanotic congenital heart disease (odds ratio, 7.35; p < 0.001) and spinal cord injury (odds ratio, 8.85; p = 0.008) strongly predicted the use of pharmacologic and mechanical thromboprophylaxis, respectively. CONCLUSIONS: Thromboprophylaxis is infrequently used in critically ill children. This is true even for children at high risk of thrombosis where consensus guidelines recommend pharmacologic thromboprophylaxis.
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Norman A Johanson; Paul F Lachiewicz; Jay R Lieberman; Paul A Lotke; Javad Parvizi; Vincent Pellegrini; Theodore A Stringer; Paul Tornetta; Robert H Haralson; William C Watters Journal: J Bone Joint Surg Am Date: 2009-07 Impact factor: 5.284
Authors: Patricia Massicotte; Jim A Julian; Michael Gent; Karen Shields; Velma Marzinotto; Barbara Szechtman; Anthony K Chan; Maureen Andrew Journal: Thromb Res Date: 2003-01-25 Impact factor: 3.944
Authors: Rakesh Patel; Deborah J Cook; Maureen O Meade; Lauren E Griffith; Geeta Mehta; Graeme M Rocker; John C Marshall; Rick Hodder; Claudio M Martin; Daren K Heyland; Sharon Peters; John Muscedere; Mark Soth; Nicole Campbell; Gordon H Guyatt Journal: J Crit Care Date: 2005-12 Impact factor: 3.425
Authors: Alexander T Cohen; Victor F Tapson; Jean-Francois Bergmann; Samuel Z Goldhaber; Ajay K Kakkar; Bruno Deslandes; Wei Huang; Maksim Zayaruzny; Leigh Emery; Frederick A Anderson Journal: Lancet Date: 2008-02-02 Impact factor: 79.321
Authors: Scott L Weiss; Julie C Fitzgerald; Edward Vincent Faustino; Marino S Festa; Ericka L Fink; Philippe Jouvet; Jenny L Bush; Niranjan Kissoon; John Marshall; Vinay M Nadkarni; Neal J Thomas Journal: Pediatr Crit Care Med Date: 2014-09 Impact factor: 3.624
Authors: Amee M Bigelow; Katherine T Flynn-O'Brien; Pippa M Simpson; Mahua Dasgupta; Sheila J Hanson Journal: Pediatr Crit Care Med Date: 2018-09 Impact factor: 3.624
Authors: Victoria C Ziesenitz; Tatjana Welzel; Madelé van Dyk; Patrick Saur; Matthias Gorenflo; Johannes N van den Anker Journal: Paediatr Drugs Date: 2022-09-02 Impact factor: 3.930
Authors: Sara-Jane N Onyeama; Sheila J Hanson; Mahua Dasgupta; Raymond G Hoffmann; Edward Vincent S Faustino Journal: Pediatr Crit Care Med Date: 2016-08 Impact factor: 3.624
Authors: Michael F Canarie; Suzanne Barry; Christopher L Carroll; Amanda Hassinger; Sarah Kandil; Simon Li; Matthew Pinto; Stacey L Valentine; E Vincent S Faustino Journal: Pediatr Crit Care Med Date: 2015-10 Impact factor: 3.624