OBJECTIVES: To determine the optimal effective dose of sodium pyruvate in maintaining the vital signs following hemorrhagic shock (HS) in rats. MATERIALS AND METHODS: Anesthetized, male Sprague-Dawley rats underwent computer-controlled HS for 30 minute followed by fluid resuscitation with either hypertonic saline, or sodium pyruvate solutions of 0.5 M, 1.0 M, 2.0 M, and 4.0 M at a rate of 5ml/kg/h (60 minute) and subsequent blood infusion (60 minute). The results were compared with sham and non- resuscitated groups. The animals were continuously monitored for mean arterial pressure, systolic and diastolic pressure, heart rate, pulse pressure, temperature, shock index and Kerdo index (KI). RESULTS: The Sham group remained stable throughout the experiment. Non-resuscitated HS animals did not survive for the entire experiment due to non-viable vital signs and poor shock and KI. All fluids were effective in normalizing the vital signs when shed blood was used adjunctively. Sodium pyruvate 2.0 M was most effective, and 4.0 M solution was least effective in improving the vital signs after HS. CONCLUSIONS: Future studies should be directed to use 2.0 M sodium pyruvate adjuvant for resuscitation on multiorgan failure and survival rate in HS.
OBJECTIVES: To determine the optimal effective dose of sodium pyruvate in maintaining the vital signs following hemorrhagic shock (HS) in rats. MATERIALS AND METHODS: Anesthetized, male Sprague-Dawley rats underwent computer-controlled HS for 30 minute followed by fluid resuscitation with either hypertonic saline, or sodium pyruvate solutions of 0.5 M, 1.0 M, 2.0 M, and 4.0 M at a rate of 5ml/kg/h (60 minute) and subsequent blood infusion (60 minute). The results were compared with sham and non- resuscitated groups. The animals were continuously monitored for mean arterial pressure, systolic and diastolic pressure, heart rate, pulse pressure, temperature, shock index and Kerdo index (KI). RESULTS: The Sham group remained stable throughout the experiment. Non-resuscitated HS animals did not survive for the entire experiment due to non-viable vital signs and poor shock and KI. All fluids were effective in normalizing the vital signs when shed blood was used adjunctively. Sodium pyruvate 2.0 M was most effective, and 4.0 M solution was least effective in improving the vital signs after HS. CONCLUSIONS: Future studies should be directed to use 2.0 M sodium pyruvate adjuvant for resuscitation on multiorgan failure and survival rate in HS.
Authors: Hasan B Alam; Kathleen Stanton; Elena Koustova; David Burris; Norman Rich; Peter Rhee Journal: Resuscitation Date: 2004-01 Impact factor: 5.262
Authors: R Bellamy; P Safar; S A Tisherman; R Basford; S P Bruttig; A Capone; M A Dubick; L Ernster; B G Hattler; P Hochachka; M Klain; P M Kochanek; W A Kofke; J R Lancaster; F X McGowan; P R Oeltgen; J W Severinghaus; M J Taylor; H Zar Journal: Crit Care Med Date: 1996-02 Impact factor: 7.598
Authors: Joseph F Kelly; Amber E Ritenour; Daniel F McLaughlin; Karen A Bagg; Amy N Apodaca; Craig T Mallak; Lisa Pearse; Mary M Lawnick; Howard R Champion; Charles E Wade; John B Holcomb Journal: J Trauma Date: 2008-02