Fredrick J Bohanon1, Amy A Mrazek1, Mohamed T Shabana1, Sarah Mims1, Geetha L Radhakrishnan2, George C Kramer3, Ravi S Radhakrishnan4. 1. Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA. 2. Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA. 3. Department of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA. 4. Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA; Department of Pediatrics, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555, USA. Electronic address: rsradhak@utmb.edu.
Abstract
BACKGROUND: Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups. METHODS: With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain. RESULTS: HRV measurements in time domain, heart rate, and pulse oximetry (SpO2) were significantly different in septic patients vs nonseptic controls. CONCLUSIONS: These results indicate that nonconventional vital signs such as HRV are more sensitive than traditionally used vital signs, such as cardiac output and mean arterial pressure, in the confirmation of sepsis in extremely low birth weight neonates. HRV may allow for earlier identification of septic physiology.
BACKGROUND:Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups. METHODS: With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain. RESULTS: HRV measurements in time domain, heart rate, and pulse oximetry (SpO2) were significantly different in septic patients vs nonseptic controls. CONCLUSIONS: These results indicate that nonconventional vital signs such as HRV are more sensitive than traditionally used vital signs, such as cardiac output and mean arterial pressure, in the confirmation of sepsis in extremely low birth weight neonates. HRV may allow for earlier identification of septic physiology.
Authors: R Shayn Martin; Patrick R Norris; Patrick D Kilgo; Preston R Miller; J Jason Hoth; J Wayne Meredith; Michael C Chang; John A Morris Journal: J Trauma Date: 2006-05
Authors: Li Liu; Shefali Oza; Daniel Hogan; Jamie Perin; Igor Rudan; Joy E Lawn; Simon Cousens; Colin Mathers; Robert E Black Journal: Lancet Date: 2014-09-30 Impact factor: 79.321
Authors: Leena B Mithal; Ram Yogev; Hannah L Palac; Daniel Kaminsky; Ilan Gur; Karen K Mestan Journal: Early Hum Dev Date: 2018-01-23 Impact factor: 2.079
Authors: Alissa L Meister; Fumiyuki C Gardner; Kirsteen N Browning; R Alberto Travagli; Charles Palmer; Kim Kopenhaver Doheny Journal: Adv Neonatal Care Date: 2021-12-01 Impact factor: 1.874
Authors: Aaron J Masino; Mary Catherine Harris; Daniel Forsyth; Svetlana Ostapenko; Lakshmi Srinivasan; Christopher P Bonafide; Fran Balamuth; Melissa Schmatz; Robert W Grundmeier Journal: PLoS One Date: 2019-02-22 Impact factor: 3.240
Authors: Stephanie C Garbern; Gabin Mbanjumucyo; Christian Umuhoza; Vinay K Sharma; James Mackey; Oliver Tang; Kyle D Martin; Francois R Twagirumukiza; Samantha L Rosman; Natalie McCall; Stephan W Wegerich; Adam C Levine Journal: Digit Health Date: 2019-09-30