Kemal Ozgur1, Murat Berkkanoglu2, Hasan Bulut2, Peter Humaidan3, Kevin Coetzee2. 1. Antalya IVF, Özel Antalya Tüp Bebek Merkezi, Antalya, Turkey. Electronic address: kemalozg@yahoo.com. 2. Antalya IVF, Özel Antalya Tüp Bebek Merkezi, Antalya, Turkey. 3. The Fertility Clinic, Skive Regional Hospital and Faculty of Health, Aarhus University, Aarhus, Denmark.
Abstract
OBJECTIVE: To investigate the possible effect of controlled ovarian stimulation on the perinatal outcomes of assisted reproductive technology pregnancies, by comparing the outcomes from fresh ET with frozen ET (FET) with blastocysts of similar quality. DESIGN: Retrospective observational study. SETTING: Private fertility center. PATIENT(S): Seven hundred eighty-four fresh transfers and 382 vitrified-warmed double blastocyst transfers. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Miscarriage, perinatal mortality, preterm delivery, live birth, live-birth weights, and gestational age of live births. RESULT(S): FET resulted in higher implantation rates (51.5% vs. 40.6%), higher live-birth rates per transfer (56.8% vs. 44.3%), and lower ectopic pregnancy rates (0.32% vs. 1.80%). FET pregnancies also had higher day 14 βhCG levels per implantation (148.2 vs. 176.2 IU/L) and higher infant birth weights (singletons Δ109.4 g, twins Δ124 g). Female infants benefitted the most in terms of birth weight. Miscarriage, premature delivery, perinatal morbidity, and live birth per pregnancy were all nonsignificantly different between fresh ET and FET. CONCLUSION(S): Clinically significant differences between the peri-implantation and perinatal outcomes of fresh ET and FET suggest better endometrial receptivity and placentation in FET cycles.
OBJECTIVE: To investigate the possible effect of controlled ovarian stimulation on the perinatal outcomes of assisted reproductive technology pregnancies, by comparing the outcomes from fresh ET with frozen ET (FET) with blastocysts of similar quality. DESIGN: Retrospective observational study. SETTING: Private fertility center. PATIENT(S): Seven hundred eighty-four fresh transfers and 382 vitrified-warmed double blastocyst transfers. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Miscarriage, perinatal mortality, preterm delivery, live birth, live-birth weights, and gestational age of live births. RESULT(S): FET resulted in higher implantation rates (51.5% vs. 40.6%), higher live-birth rates per transfer (56.8% vs. 44.3%), and lower ectopic pregnancy rates (0.32% vs. 1.80%). FET pregnancies also had higher day 14 βhCG levels per implantation (148.2 vs. 176.2 IU/L) and higher infant birth weights (singletons Δ109.4 g, twins Δ124 g). Female infants benefitted the most in terms of birth weight. Miscarriage, premature delivery, perinatal morbidity, and live birth per pregnancy were all nonsignificantly different between fresh ET and FET. CONCLUSION(S): Clinically significant differences between the peri-implantation and perinatal outcomes of fresh ET and FET suggest better endometrial receptivity and placentation in FET cycles.
Authors: Kemal Ozgur; Murat Berkkanoglu; Hasan Bulut; Peter Humaidan; Kevin Coetzee Journal: J Assist Reprod Genet Date: 2015-12-23 Impact factor: 3.412
Authors: Kemal Ozgur; Hasan Bulut; Murat Berkkanoglu; Peter Humaidan; Kevin Coetzee Journal: J Assist Reprod Genet Date: 2017-09-22 Impact factor: 3.412
Authors: Julia F Litzky; Sheree L Boulet; Navid Esfandiari; Yujia Zhang; Dmitry M Kissin; Regan N Theiler; Carmen J Marsit Journal: Am J Obstet Gynecol Date: 2017-12-29 Impact factor: 8.661