PURPOSE: This paper aims to investigate the efficacy of IVF with preimplantation genetic testing for aneuploidy (PGT-A), using only best-scoring blastocysts from young (≤ 35 years) infertile patients undergoingsingle blastocyst frozen embryo transfers (FET). METHOD: In this randomized controlled trial (RCT) registered 29 March 2017, 302 infertile patient-couples eligible to participate underwentautologous ICSI blastocyst freeze-all cycles. Two-hundred and twenty patient-couples satisfied the inclusion criteria (i.e., female age ≤ 35 years, two-day 5 ≥ 2BB blastocysts) and were randomized to either the PGT-A (PGT-A group, n = 109) selection arm or morphology score (morphology group, n = 111) selection arm. In both arms, the highest ranking (by morphological score) blastocysts were selected for FET. RESULTS: Of the 109 best-scoring blastocysts that underwent PGT-A, 80 were predicted to be euploid (73.4%) and were transferred in FET (euploid subgroup). There was no statistical difference in LB rate between the euploid subgroup and morphology group (56.3% vs 58.6%, odds ratio 0.91 (95% CI 0.51-1.63), p = 0.750). In a multiple logistic regression, the transfer of euploid blastocysts was not found to be a significant predictor of LB when adjusting for female age, infertility duration, antral follicle count, and blastocyst quality, with the independent odds expressed as 0.91 (95% CI 0.50-1.66, p = 0.760). CONCLUSION:In young (≤ 35 years) infertile patients with at least two ≥ 2BB blastocysts, PGT-A blastocyst selection does not result in an enhanced LB rate, with the evidence suggesting that the effectivity of PGT-A may be limited by the effectivity of TE biopsy. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT03095053.
RCT Entities:
PURPOSE: This paper aims to investigate the efficacy of IVF with preimplantation genetic testing for aneuploidy (PGT-A), using only best-scoring blastocysts from young (≤ 35 years) infertilepatients undergoing single blastocyst frozen embryo transfers (FET). METHOD: In this randomized controlled trial (RCT) registered 29 March 2017, 302 infertilepatient-couples eligible to participate underwent autologous ICSI blastocyst freeze-all cycles. Two-hundred and twenty patient-couples satisfied the inclusion criteria (i.e., female age ≤ 35 years, two-day 5 ≥ 2BB blastocysts) and were randomized to either the PGT-A (PGT-A group, n = 109) selection arm or morphology score (morphology group, n = 111) selection arm. In both arms, the highest ranking (by morphological score) blastocysts were selected for FET. RESULTS: Of the 109 best-scoring blastocysts that underwent PGT-A, 80 were predicted to be euploid (73.4%) and were transferred in FET (euploid subgroup). There was no statistical difference in LB rate between the euploid subgroup and morphology group (56.3% vs 58.6%, odds ratio 0.91 (95% CI 0.51-1.63), p = 0.750). In a multiple logistic regression, the transfer of euploid blastocysts was not found to be a significant predictor of LB when adjusting for female age, infertility duration, antral follicle count, and blastocyst quality, with the independent odds expressed as 0.91 (95% CI 0.50-1.66, p = 0.760). CONCLUSION: In young (≤ 35 years) infertilepatients with at least two ≥ 2BB blastocysts, PGT-A blastocyst selection does not result in an enhanced LB rate, with the evidence suggesting that the effectivity of PGT-A may be limited by the effectivity of TE biopsy. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT03095053.
Authors: Sebastiaan Mastenbroek; Moniek Twisk; Jannie van Echten-Arends; Birgit Sikkema-Raddatz; Johanna C Korevaar; Harold R Verhoeve; Niels E A Vogel; Eus G J M Arts; Jan W A de Vries; Patrick M Bossuyt; Charles H C M Buys; Maas Jan Heineman; Sjoerd Repping; Fulco van der Veen Journal: N Engl J Med Date: 2007-07-04 Impact factor: 91.245
Authors: Eric J Forman; Kathleen H Hong; Kathleen M Ferry; Xin Tao; Deanne Taylor; Brynn Levy; Nathan R Treff; Richard T Scott Journal: Fertil Steril Date: 2013-03-30 Impact factor: 7.329
Authors: Richard T Scott; Kathleen M Upham; Eric J Forman; Kathleen H Hong; Katherine L Scott; Deanne Taylor; Xin Tao; Nathan R Treff Journal: Fertil Steril Date: 2013-06-01 Impact factor: 7.329
Authors: Zhihong Yang; Jiaen Liu; Gary S Collins; Shala A Salem; Xiaohong Liu; Sarah S Lyle; Alison C Peck; E Scott Sills; Rifaat D Salem Journal: Mol Cytogenet Date: 2012-05-02 Impact factor: 2.009