Literature DB >> 26202124

Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant.

Tommaso Giani1, Fabio Arena1, Guendalina Vaggelli2, Viola Conte1, Adriana Chiarelli1, Lucia Henrici De Angelis1, Rossella Fornaini3, Maddalena Grazzini4, Fabrizio Niccolini4, Patrizia Pecile2, Gian Maria Rossolini5.   

Abstract

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26202124      PMCID： PMC4572530          DOI： 10.1128/JCM.01017-15

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  24 in total

1.  Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258.

Authors:  Tatiana Bogdanovich; Jennifer M Adams-Haduch; Guo-Bao Tian; Minh Hong Nguyen; Eun Jeong Kwak; Carlene A Muto; Yohei Doi
Journal:  Clin Infect Dis       Date:  2011-08       Impact factor: 9.079

2.  In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment.

Authors:  Antonio Cannatelli; Vincenzo Di Pilato; Tommaso Giani; Fabio Arena; Simone Ambretti; Paolo Gaibani; Marco Maria D'Andrea; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2014-05-19       Impact factor: 5.191

3.  Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study.

Authors:  Olympia Zarkotou; Spyros Pournaras; Evangelia Voulgari; Georgios Chrysos; Athanassios Prekates; Dionysios Voutsinas; Katerina Themeli-Digalaki; Athanassios Tsakris
Journal:  J Clin Microbiol       Date:  2010-04-07       Impact factor: 5.948

Review 4.  Colistin resistance in Klebsiella pneumoniae.

Authors:  Young-Mi Ah; Ah-Jung Kim; Ju-Yeun Lee
Journal:  Int J Antimicrob Agents       Date:  2014-04-12       Impact factor: 5.283

5.  Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.

Authors:  Meredith S Wright; Yo Suzuki; Marcus B Jones; Steven H Marshall; Susan D Rudin; David van Duin; Keith Kaye; Michael R Jacobs; Robert A Bonomo; Mark D Adams
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

6.  Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014.

Authors:  M Monaco; T Giani; M Raffone; F Arena; A Garcia-Fernandez; S Pollini; H Grundmann; A Pantosti; G M Rossolini
Journal:  Euro Surveill       Date:  2014-10-23

Review 7.  Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.

Authors:  L S Tzouvelekis; A Markogiannakis; M Psichogiou; P T Tassios; G L Daikos
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

8.  Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems.

Authors:  George L Daikos; Sophia Tsaousi; Leonidas S Tzouvelekis; Ioannis Anyfantis; Mina Psichogiou; Athina Argyropoulou; Ioanna Stefanou; Vana Sypsa; Vivi Miriagou; Martha Nepka; Sarah Georgiadou; Antonis Markogiannakis; Dimitris Goukos; Athanasios Skoutelis
Journal:  Antimicrob Agents Chemother       Date:  2014-02-10       Impact factor: 5.191

9.  The role of colonization pressure in the dissemination of colistin or tigecycline resistant KPC-producing Klebsiella pneumoniae in critically ill patients.

Authors:  M Papadimitriou-Olivgeris; M Christofidou; F Fligou; C Bartzavali; T Vrettos; K S Filos; M Marangos; E D Anastassiou
Journal:  Infection       Date:  2014-07-10       Impact factor: 3.553

10.  Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011.

Authors:  T Giani; B Pini; F Arena; V Conte; S Bracco; R Migliavacca; A Pantosti; L Pagani; F Luzzaro; G M Rossolini
Journal:  Euro Surveill       Date:  2013-05-30
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  48 in total

1.  Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.

Authors:  Fabio Arena; Lucia Henrici De Angelis; Antonio Cannatelli; Vincenzo Di Pilato; Marina Amorese; Marco Maria D'Andrea; Tommaso Giani; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

2.  Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1.

Authors:  Sue C Nang; Mei-Ling Han; Heidi H Yu; Jiping Wang; Von Vergel L Torres; Chongshan Dai; Tony Velkov; Marina Harper; Jian Li
Journal:  J Antimicrob Chemother       Date:  2019-11-01       Impact factor: 5.790

Review 3.  Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.

Authors:  Laurent Poirel; Aurélie Jayol; Patrice Nordmann
Journal:  Clin Microbiol Rev       Date:  2017-04       Impact factor: 26.132

4.  Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA.

Authors:  Astrid V Cienfuegos-Gallet; Liang Chen; Barry N Kreiswirth; J Natalia Jiménez
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

5.  Meropenem for treating KPC-producing Klebsiella pneumoniae bloodstream infections: Should we get to the PK/PD root of the paradox?

Authors:  Valerio Del Bono; Daniele Roberto Giacobbe; Anna Marchese; Andrea Parisini; Carmen Fucile; Erika Coppo; Valeria Marini; Antonio Arena; Alexandre Molin; Antonietta Martelli; Angelo Gratarola; Claudio Viscoli; Paolo Pelosi; Francesca Mattioli
Journal:  Virulence       Date:  2016-07-18       Impact factor: 5.882

6.  Rapid Detection of Polymyxin-Resistant Enterobacteriaceae from Blood Cultures.

Authors:  Aurélie Jayol; Véronique Dubois; Laurent Poirel; Patrice Nordmann
Journal:  J Clin Microbiol       Date:  2016-06-15       Impact factor: 5.948

7.  Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: De Novo or Drug Exposure?

Authors:  Nenad Macesic; Brian Nelson; Anne-Catrin Uhlemann
Journal:  Clin Infect Dis       Date:  2017-08-15       Impact factor: 9.079

Review 8.  MCR: modern colistin resistance.

Authors:  I Caniaux; A van Belkum; G Zambardi; L Poirel; M F Gros
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-11-21       Impact factor: 3.267

9.  Polymyxin Resistance in Klebsiella pneumoniae: Complexity at Every Level.

Authors:  Yohei Doi; David van Duin
Journal:  Clin Infect Dis       Date:  2020-05-06       Impact factor: 9.079

10.  Synergistic activity of synthetic N-terminal peptide of human lactoferrin in combination with various antibiotics against carbapenem-resistant Klebsiella pneumoniae strains.

Authors:  P Morici; W Florio; C Rizzato; E Ghelardi; A Tavanti; G M Rossolini; A Lupetti
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-05-03       Impact factor: 3.267
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