| Literature DB >> 28507118 |
Astrid V Cienfuegos-Gallet1, Liang Chen2, Barry N Kreiswirth2, J Natalia Jiménez3.
Abstract
Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.Entities:
Keywords: Klebsiella pneumoniae; carbapenem resistance; colistin resistance; mgrB
Mesh:
Substances:
Year: 2017 PMID: 28507118 PMCID: PMC5527652 DOI: 10.1128/AAC.00404-17
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191