Literature DB >> 26824959

Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.

Fabio Arena1, Lucia Henrici De Angelis1, Antonio Cannatelli1, Vincenzo Di Pilato2, Marina Amorese1, Marco Maria D'Andrea1, Tommaso Giani1, Gian Maria Rossolini3.   

Abstract

Using aGalleria mellonellaanimal model, we compared the virulence of two sequence type 258 (ST258) KPC-producingKlebsiella pneumoniaestrains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistantmgrBmutants. With both strains, themgrBmutants did not exhibit modification in virulence. In theG. mellonellamodel, the clade 1 strain (capsular typecps-1[wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular typecps-2[wzi154, producing KPC-3]).
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 26824959      PMCID： PMC4808163          DOI： 10.1128/AAC.02981-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  KPC-producing, multidrug-resistant Klebsiella pneumoniae sequence type 258 as a typical opportunistic pathogen.

Authors:  L S Tzouvelekis; V Miriagou; S D Kotsakis; K Spyridopoulou; E Athanasiou; E Karagouni; E Tzelepi; G L Daikos
Journal:  Antimicrob Agents Chemother       Date:  2013-07-15       Impact factor: 5.191

2.  Colistin-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae belonging to the international epidemic clone ST258.

Authors:  Tatiana Bogdanovich; Jennifer M Adams-Haduch; Guo-Bao Tian; Minh Hong Nguyen; Eun Jeong Kwak; Carlene A Muto; Yohei Doi
Journal:  Clin Infect Dis       Date:  2011-08       Impact factor: 9.079

3.  Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.

Authors:  Frank R Deleo; Liang Chen; Stephen F Porcella; Craig A Martens; Scott D Kobayashi; Adeline R Porter; Kalyan D Chavda; Michael R Jacobs; Barun Mathema; Randall J Olsen; Robert A Bonomo; James M Musser; Barry N Kreiswirth
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-17       Impact factor: 11.205

4.  Modeling Klebsiella pneumoniae pathogenesis by infection of the wax moth Galleria mellonella.

Authors:  José Luis Insua; Enrique Llobet; David Moranta; Camino Pérez-Gutiérrez; Anna Tomás; Junkal Garmendia; José A Bengoechea
Journal:  Infect Immun       Date:  2013-07-08       Impact factor: 3.441

5.  Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

Authors:  Rafael López-Rojas; Juan Domínguez-Herrera; Michael J McConnell; Fernando Docobo-Peréz; Younes Smani; María Fernández-Reyes; Luis Rivas; Jerónimo Pachón
Journal:  J Infect Dis       Date:  2011-01-07       Impact factor: 5.226

Review 6.  Treatment of carbapenem-resistant Klebsiella pneumoniae: the state of the art.

Authors:  Nicola Petrosillo; Maddalena Giannella; Russell Lewis; Pierluigi Viale
Journal:  Expert Rev Anti Infect Ther       Date:  2013-02       Impact factor: 5.091

7.  Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii.

Authors:  Alejandro Beceiro; Antonio Moreno; Nathalie Fernández; Juán A Vallejo; Jesús Aranda; Ben Adler; Marina Harper; John D Boyce; Germán Bou
Journal:  Antimicrob Agents Chemother       Date:  2013-11-04       Impact factor: 5.191

8.  Growth retardation, reduced invasiveness, and impaired colistin-mediated cell death associated with colistin resistance development in Acinetobacter baumannii.

Authors:  Spyros Pournaras; Aggeliki Poulou; Konstantina Dafopoulou; Yassine Nait Chabane; Ioulia Kristo; Demosthenes Makris; Julie Hardouin; Pascal Cosette; Athanassios Tsakris; Emmanuelle Dé
Journal:  Antimicrob Agents Chemother       Date:  2013-11-18       Impact factor: 5.191

9.  In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator.

Authors:  Antonio Cannatelli; Marco Maria D'Andrea; Tommaso Giani; Vincenzo Di Pilato; Fabio Arena; Simone Ambretti; Paolo Gaibani; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2013-08-26       Impact factor: 5.191

10.  Diversity of capsular polysaccharide gene clusters in Kpc-producing Klebsiella pneumoniae clinical isolates of sequence type 258 involved in the Italian epidemic.

Authors:  Marco Maria D'Andrea; Francesco Amisano; Tommaso Giani; Viola Conte; Nagaia Ciacci; Simone Ambretti; Luisa Santoriello; Gian Maria Rossolini
Journal:  PLoS One       Date:  2014-05-13       Impact factor: 3.240
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  11 in total

1.  Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae: pharmacodynamics and morphological changes.

Authors:  Rajnikant Sharma; Saloni Patel; Cely Abboud; John Diep; Neang S Ly; Jason M Pogue; Keith S Kaye; Jian Li; Gauri G Rao
Journal:  Int J Antimicrob Agents       Date:  2016-12-23       Impact factor: 5.283

2.  Octapeptin C4 and polymyxin resistance occur via distinct pathways in an epidemic XDR Klebsiella pneumoniae ST258 isolate.

Authors:  Miranda E Pitt; Minh Duc Cao; Mark S Butler; Soumya Ramu; Devika Ganesamoorthy; Mark A T Blaskovich; Lachlan J M Coin; Matthew A Cooper
Journal:  J Antimicrob Chemother       Date:  2019-03-01       Impact factor: 5.790

3.  Differences in Inflammatory Response Induced by Two Representatives of Clades of the Pandemic ST258 Klebsiella pneumoniae Clonal Lineage Producing KPC-Type Carbapenemases.

Authors:  Giuseppe Castronovo; Ann Maria Clemente; Alberto Antonelli; Marco Maria D'Andrea; Michele Tanturli; Eloisa Perissi; Sara Paccosi; Astrid Parenti; Federico Cozzolino; Gian Maria Rossolini; Maria Gabriella Torcia
Journal:  PLoS One       Date:  2017-01-12       Impact factor: 3.240

4.  Multifactorial chromosomal variants regulate polymyxin resistance in extensively drug-resistant Klebsiella pneumoniae.

Authors:  Miranda E Pitt; Alysha G Elliott; Minh Duc Cao; Devika Ganesamoorthy; Ilias Karaiskos; Helen Giamarellou; Cely S Abboud; Mark A T Blaskovich; Matthew A Cooper; Lachlan J M Coin
Journal:  Microb Genom       Date:  2018-02-12

Review 5.  Infections caused by carbapenem-resistant Klebsiella pneumoniae with hypermucoviscous phenotype: A case report and literature review.

Authors:  Fabio Arena; Lucia Henrici De Angelis; Marco Maria D'Andrea; Antonio Cannatelli; Lucina Fossati; Vincenzo Di Pilato; Tommaso Giani; Rossana Cavallo; Gian Maria Rossolini
Journal:  Virulence       Date:  2017-02-23       Impact factor: 5.882

6.  Molecular Epidemiology and Virulence Profiles of Colistin-Resistant Klebsiella pneumoniae Blood Isolates From the Hospital Agency "Ospedale dei Colli," Naples, Italy.

Authors:  Eliana P Esposito; Matteo Cervoni; Mariano Bernardo; Valeria Crivaro; Susanna Cuccurullo; Francesco Imperi; Raffaele Zarrilli
Journal:  Front Microbiol       Date:  2018-07-16       Impact factor: 5.640

7.  Predicting Phenotypic Polymyxin Resistance in Klebsiella pneumoniae through Machine Learning Analysis of Genomic Data.

Authors:  Nenad Macesic; Oliver J Bear Don't Walk; Itsik Pe'er; Nicholas P Tatonetti; Anton Y Peleg; Anne-Catrin Uhlemann
Journal:  mSystems       Date:  2020-05-26       Impact factor: 6.496

8.  Effects of the Antimicrobial Peptide LL-37 and Innate Effector Mechanisms in Colistin-Resistant Klebsiella pneumoniae With mgrB Insertions.

Authors:  Hissa M Al-Farsi; Salma Al-Adwani; Sultan Ahmed; Carmen Vogt; Anoop T Ambikan; Anna Leber; Amina Al-Jardani; Saleh Al-Azri; Zakariya Al-Muharmi; Muhammet S Toprak; Christian G Giske; Peter Bergman
Journal:  Front Microbiol       Date:  2019-11-14       Impact factor: 5.640

9.  φBO1E, a newly discovered lytic bacteriophage targeting carbapenemase-producing Klebsiella pneumoniae of the pandemic Clonal Group 258 clade II lineage.

Authors:  Marco Maria D'Andrea; Pasquale Marmo; Lucia Henrici De Angelis; Mattia Palmieri; Nagaia Ciacci; Gustavo Di Lallo; Elisa Demattè; Elisa Vannuccini; Pietro Lupetti; Gian Maria Rossolini; Maria Cristina Thaller
Journal:  Sci Rep       Date:  2017-06-01       Impact factor: 4.379

10.  Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains.

Authors:  Ning Dong; Xuemei Yang; Rong Zhang; Edward Wai-Chi Chan; Sheng Chen
Journal:  Emerg Microbes Infect       Date:  2018-08-12       Impact factor: 7.163
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