Clifford R Jack1, Josephine Barnes2, Matt A Bernstein3, Bret J Borowski3, James Brewer4, Shona Clegg2, Anders M Dale4, Owen Carmichael5, Christopher Ching6, Charles DeCarli7, Rahul S Desikan8, Christine Fennema-Notestine9, Anders M Fjell10, Evan Fletcher7, Nick C Fox2, Jeff Gunter3, Boris A Gutman6, Dominic Holland4, Xue Hua6, Philip Insel11, Kejal Kantarci3, Ron J Killiany12, Gunnar Krueger13, Kelvin K Leung14, Scott Mackin15, Pauline Maillard7, Ian B Malone2, Niklas Mattsson16, Linda McEvoy8, Marc Modat17, Susanne Mueller18, Rachel Nosheny18, Sebastien Ourselin17, Norbert Schuff18, Matthew L Senjem3, Alix Simonson11, Paul M Thompson6, Dan Rettmann19, Prashanthi Vemuri3, Kristine Walhovd10, Yansong Zhao20, Samantha Zuk3, Michael Weiner21. 1. Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: jack.clifford@mayo.edu. 2. Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK. 3. Department of Radiology, Mayo Clinic, Rochester, MN, USA. 4. Department of Neuroscience, University of California at San Diego, La Jolla, CA, USA. 5. Department of Neurology, University of California at Davis, Davis, CA, USA. 6. Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Marina del Rey, CA, USA. 7. Department of Neurology, University of California at Davis, Davis, CA, USA; Center for Neuroscience, University of California at Davis, Davis, CA, USA. 8. Department of Radiology, University of California at San Diego, La Jolla, CA, USA. 9. Department of Radiology, University of California at San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA. 10. Department of Psychology, University of Oslo, Oslo, Norway. 11. Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. 12. Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. 13. Siemens Medical Solutions, Boston, MA, USA. 14. Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom. 15. Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA. 16. Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden. 17. Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, UK; Translational Imaging Group, Centre for Medical Image Computing, University College London, London, United Kingdom. 18. Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA. 19. MR Applications and Workflow, GE Healthcare, Rochester, MN, USA. 20. Philips Healthcare, Cleveland, OH, USA. 21. Department of Radiology and Biomedical Imaging, Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Psychiatry, University of California at San Francisco, San Francisco, CA, USA; Department of Radiology, University of California at San Francisco, San Francisco, CA, USA; Department of Medicine, University of California at San Francisco, San Francisco, CA, USA; Department of Neurology, University of California at San Francisco, San Francisco, CA, USA.
Abstract
INTRODUCTION: Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. METHODS: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. RESULTS: Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. DISCUSSION: Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.
INTRODUCTION:Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. METHODS: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. RESULTS: Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. DISCUSSION: Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.
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