| Literature DB >> 26192084 |
Alan Urban1,2, Clara Dussaux1,2, Guillaume Martel1, Clément Brunner1,2,3, Emilie Mace4, Gabriel Montaldo1,2.
Abstract
Innovative imaging methods help to investigate the complex relationship between brain activity and behavior in freely moving animals. Functional ultrasound (fUS) is an imaging modality suitable for recording cerebral blood volume (CBV) dynamics in the whole brain but has so far been used only in head-fixed and anesthetized rodents. We designed a fUS device for tethered brain imaging in freely moving rats based on a miniaturized ultrasound probe and a custom-made ultrasound scanner. We monitored CBV changes in rats during various behavioral states such as quiet rest, after whisker or visual stimulations, and in a food-reinforced operant task. We show that fUS imaging in freely moving rats could efficiently decode brain activity in real time.Entities:
Mesh：
Year: 2015 PMID： 26192084 DOI： 10.1038/nmeth.3482
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547