Literature DB >> 26191373

Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.

Joanna Ombouma1, Daniella Vullo2, Pascal Dumy1, Claudiu T Supuran3, Jean-Yves Winum1.   

Abstract

A general approach for the synthesis of carbonic anhydrases glycoinhibitors belonging to an aminoxysulfonamide series is presented using a Ferrier sulfonamidoglycosylation reaction on glycals. All the compounds showed good in vitro inhibitory activity against four human carbonic anhydrase isoforms, with selectivity against the cytosolic (hCA II) vs the tumor associated (hCA IX and XII) enzymes.

Entities:  

Keywords:  Ferrier rearrangement; Glycoinhibitor; aminoxysulfonamide; carbonic anhydrase; zinc binding function

Year:  2015        PMID： 26191373      PMCID： PMC4499834          DOI： 10.1021/acsmedchemlett.5b00175

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


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