Literature DB >> 23689938

Thiol-ene click chemistry for the synthesis of highly effective glycosyl sulfonamide carbonic anhydrase inhibitors.

Mohamed-Chiheb Saada1, Joanna Ombouma, Jean-Louis Montero, Claudiu T Supuran, Jean-Yves Winum.   

Abstract

Thiol-ene click chemistry has been applied for obtaining sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitors incorporating sugar moieties. Most of these new compounds were moderate CA I inhibitors, effective CA II inhibitors, and low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms CA IX and XII.

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Year:  2013        PMID： 23689938     DOI： 10.1039/c3cc42541j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.

Authors:  Nicolino Pala; Laura Micheletto; Mario Sechi; Mayank Aggarwal; Fabrizio Carta; Robert McKenna; Claudiu T Supuran
Journal:  ACS Med Chem Lett       Date:  2014-06-07       Impact factor: 4.345

2.  Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.

Authors:  Joanna Ombouma; Daniella Vullo; Pascal Dumy; Claudiu T Supuran; Jean-Yves Winum
Journal:  ACS Med Chem Lett       Date:  2015-06-02       Impact factor: 4.345

3.  Synthesis of Conformationally-Locked cis- and trans-Bicyclo[4.4.0] Mono-, Di-, and Trioxadecane Modifications of Galacto- and Glucopyranose; Experimental Limiting 3JH,H Coupling Constants for the Estimation of Carbohydrate Side Chain Populations and Beyond.

Authors:  Harsha Amarasekara; Suresh Dharuman; Takayuki Kato; David Crich
Journal:  J Org Chem       Date:  2018-01-03       Impact factor: 4.354
  3 in total

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