Literature DB >> 26191368

Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to β-Lactam Antibiotics.

Xi-Le Hu1, Dan Li2, Lei Shao2, Xiaojing Dong2, Xiao-Peng He1, Guo-Rong Chen1, Daijie Chen2.   

Abstract

We show here that a series of triazolyl glycolipid derivatives modularly synthesized by a "click" reaction have the ability to increase the susceptibility of a drug-resistant bacterium to β-lactam antibiotics. We determine that the glycolipids can suppress the minimal inhibitory concentration of a number of ineffective β-lactams, upward of 256-fold, for methicillin-resistant Staphylococuss aureus (MRSA). The mechanism of action has been preliminarily probed and discussed.

Entities:  

Keywords:  MRSA; Triazolyl glycolipid; click reaction; superbacteria; β-lactams

Year:  2015        PMID： 26191368      PMCID： PMC4499819          DOI： 10.1021/acsmedchemlett.5b00142

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  29 in total

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3.  The bacteria fight back.

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4.  Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A.

Authors:  Tomasz A Łeski; Alexander Tomasz
Journal:  J Bacteriol       Date:  2005-03       Impact factor: 3.490

5.  Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.

Authors:  Cui Li; Xiao-Peng He; Yin-Jie Zhang; Zhen Li; Li-Xin Gao; Xiao-Xin Shi; Juan Xie; Jia Li; Guo-Rong Chen; Yun Tang
Journal:  Eur J Med Chem       Date:  2011-06-25       Impact factor: 6.514

6.  Synthesis of novel 6-triazologlycolipids via click chemistry and their preliminary cytotoxicity assessments.

Authors:  Hai-Lin Zhang; Xiao-Peng He; Li Sheng; Yuan Yao; Wei Zhang; Xiao-Xin Shi; Jia Li; Guo-Rong Chen
Journal:  Mol Divers       Date:  2011-06-05       Impact factor: 2.943

7.  Iron(III) chloride as an efficient catalyst for stereoselective synthesis of glycosyl azides and a cocatalyst with Cu(0) for the subsequent click chemistry.

Authors:  Santosh B Salunke; N Seshu Babu; Chien-Tien Chen
Journal:  Chem Commun (Camb)       Date:  2011-08-15       Impact factor: 6.222

8.  Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

Authors:  Tyler L Harris; Roberta J Worthington; Christian Melander
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-09       Impact factor: 15.336

Review 9.  Waves of resistance: Staphylococcus aureus in the antibiotic era.

Authors:  Henry F Chambers; Frank R Deleo
Journal:  Nat Rev Microbiol       Date:  2009-09       Impact factor: 60.633

Review 10.  CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitors.

Authors:  X-P He; J Xie; Y Tang; J Li; G-R Chen
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530
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  1 in total

Review 1.  Antibacterial pyrazoles: tackling resistant bacteria.

Authors:  Mohammad A Alam
Journal:  Future Med Chem       Date:  2022-01-20       Impact factor: 3.808
  1 in total

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