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Literature DB >> 35050719

Antibacterial pyrazoles: tackling resistant bacteria.

Abstract

Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole derivatives target different metabolic pathways of both Gram-positive and Gram-negative bacteria.

Entities: Chemical

Keywords: Acinetobacter baumannii; ESKAPE pathogens; MRSA; antibacterial; antibiotics; antimicrobials; bacterial resistance; drug-resistant; pyrazole

Mesh：

Substances：

Year: 2022 PMID： 35050719 PMCID： PMC8890142 DOI： 10.4155/fmc-2021-0275

Source DB: PubMed Journal: Future Med Chem ISSN： 1756-8919 Impact factor: 3.808

99 in total

1. Identification of non-fermenting Gram-negative bacteria of clinical importance by an oligonucleotide array.

Authors: Siou Cing Su; Mario Vaneechoutte; Lenie Dijkshoorn; Yu Fang Wei; Ya Lei Chen; Tsung Chain Chang
Journal: J Med Microbiol Date: 2009-05 Impact factor: 2.472

2. The introduction of 'chemotherapy' using arsphenamine - the first magic bullet.

Authors: K J Williams
Journal: J R Soc Med Date: 2009-08 Impact factor: 5.344

3. Carbapenem and Colistin Resistance in Enterobacter: Determinants and Clones.

Authors: Zhiyong Zong; Yu Feng; Alan McNally
Journal: Trends Microbiol Date: 2021-01-08 Impact factor: 17.079

4. A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase.

Authors: Tomasz L Czarny; Eric D Brown
Journal: ACS Infect Dis Date: 2016-05-24 Impact factor: 5.084

5. New INH-pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity.

Authors: Nagabhushana Nayak; Jurupula Ramprasad; Udayakumar Dalimba
Journal: Bioorg Med Chem Lett Date: 2015-10-21 Impact factor: 2.823

Review 6. Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens.

Authors: Sirijan Santajit; Nitaya Indrawattana
Journal: Biomed Res Int Date: 2016-05-05 Impact factor: 3.411

7. Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus.

Authors: Rawan Alnufaie; Nickolas Alsup; Hansa Raj Kc; Matthew Newman; Jedidiah Whitt; Steven Andrew Chambers; David Gilmore; Mohammad A Alam
Journal: J Antibiot (Tokyo) Date: 2020-06-29 Impact factor: 2.649

8. Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria.

Authors: Jedidiah Whitt; Cameron Duke; Mohamad Akbar Ali; Steven A Chambers; Md Mahbub Kabir Khan; David Gilmore; Mohammad A Alam
Journal: ACS Omega Date: 2019-08-21

2 in total

1. Potent and Broad-Spectrum Bactericidal Activity of a Nanotechnologically Manipulated Novel Pyrazole.

Authors: Silvana Alfei; Debora Caviglia; Alessia Zorzoli; Danilo Marimpietri; Andrea Spallarossa; Matteo Lusardi; Guendalina Zuccari; Anna Maria Schito
Journal: Biomedicines Date: 2022-04-15

2. Enhanced Antibacterial Activity of a Cationic Macromolecule by Its Complexation with a Weakly Active Pyrazole Derivative.

Authors: Anna Maria Schito; Debora Caviglia; Chiara Brullo; Alessia Zorzoli; Danilo Marimpietri; Silvana Alfei
Journal: Biomedicines Date: 2022-07-06

2 in total