Yan Ling1, Cheng Peng2, Chenguang Liu3, Na Zhang3, Shouwei Yue4. 1. Department of Rehabilitation, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road Jinan, 250012, P.R. China ; Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, China. 2. Department of General surgery, Qilu Hospital of Shandong University Jinan 250102, Shandong, China. 3. Research Center of Sports Rehabilitation of Shandong Jinan 250012, Shandong, China. 4. Department of Rehabilitation, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road Jinan, 250012, P.R. China.
Abstract
OBJECTIVES: Post-operative stiffness is common after rotator cuff repair, given the difference in susceptibility and severity, the genetic factors may be involved. Interleukin 6 (IL-6) and Matrix metalloproteinases 3 (MMP-3) were previous found as key cytokines in the pathologies of adhesive capsulitis. The present study aims to investigate whether variants within the IL-6 and MMP-3 gene contributed to post-operative stiffness in a Chinese Han population. METHODS: A total of 188 patients diagnosed with rotator cuff tears treated with mini-open surgery were enrolled in this study, among which 87 patients were diagnosed as post-operative stiffness and the remaining 101 patients as controls. All subjects were genotyped for IL-6 and MMP-3 SNPs. RESULTS: The rs1800796 of IL-6 and rs679620 of MMP-3 were found significantly associated with increased susceptibility and severity of post-operative stiffness. CONCLUSION: The rs1800796 SNP of IL-6 and rs650108 SNP of MMP-3 were associated with increased risk of post-operative stiffness susceptibility and severity. This finding can be used in guiding the rehabilitation procedure after rotator cuff surgery, in another word, those with the genetic susceptibility factors should receive a more radical rehabilitation procedure and those without the susceptibility factors can be more conservative.
OBJECTIVES: Post-operative stiffness is common after rotator cuff repair, given the difference in susceptibility and severity, the genetic factors may be involved. Interleukin 6 (IL-6) and Matrix metalloproteinases 3 (MMP-3) were previous found as key cytokines in the pathologies of adhesive capsulitis. The present study aims to investigate whether variants within the IL-6 and MMP-3 gene contributed to post-operative stiffness in a Chinese Han population. METHODS: A total of 188 patients diagnosed with rotator cuff tears treated with mini-open surgery were enrolled in this study, among which 87 patients were diagnosed as post-operative stiffness and the remaining 101 patients as controls. All subjects were genotyped for IL-6 and MMP-3 SNPs. RESULTS: The rs1800796 of IL-6 and rs679620 of MMP-3 were found significantly associated with increased susceptibility and severity of post-operative stiffness. CONCLUSION: The rs1800796 SNP of IL-6 and rs650108 SNP of MMP-3 were associated with increased risk of post-operative stiffness susceptibility and severity. This finding can be used in guiding the rehabilitation procedure after rotator cuff surgery, in another word, those with the genetic susceptibility factors should receive a more radical rehabilitation procedure and those without the susceptibility factors can be more conservative.
Authors: Davide Cucchi; Antongiulio Marmotti; Silvana De Giorgi; Alberto Costa; Rocco D'Apolito; Marco Conca; Alessandro Russo; Maristella F Saccomanno; Laura de Girolamo Journal: Joints Date: 2017-12-11