Liang Fang1,2, Minjie Wu1, Hengyu Ke2, Anand Kumar1, Shaolin Yang1,3,4. 1. Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA. 2. School of Electronic Information, Wuhan University, Wuhan, Hubei, China. 3. Department of Radiology, University of Illinois at Chicago, Chicago, Illinois, USA. 4. Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA.
Abstract
PURPOSE: MR spectroscopy (MRS) can benefit from multi-element coil arrays with enhanced signal-to-noise ratio (SNR). However, how to combine the MRS data in an optimized way from a multi-element coil array has been studied much less than MRI. A recently published method and routine combination methods have detrimental effects on SNR. We present herein a new method for optimal combination of multi-coil MRS data. METHODS: Based on an analytical solution for maximizing the SNR of the combined spectrum, a new method called "adaptively optimized combination (AOC)" of MRS data from phased array coils was developed in which the inversion of the full noise correlation matrix was incorporated into the coil weighting coefficients. Simulations were carried out to demonstrate the superior performance of the proposed AOC method in various noise scenarios. Validation experiments on human subjects were performed with different voxel locations and sizes on a 3T MRI scanner using an eight-element phased array head coil. RESULTS: Compared with a recently published method (i.e., weighting with the ratio of signal to the square of noise) and routine methods, our proposed AOC method adaptively and robustly produced significant SNR improvement in the combined spectra. CONCLUSION: The simulation and human experiments demonstrate that the proposed AOC method represents the theoretical optimal combination of MR spectroscopic data from multi-element coil arrays. Magn Reson Med 75:2235-2244, 2016.
PURPOSE: MR spectroscopy (MRS) can benefit from multi-element coil arrays with enhanced signal-to-noise ratio (SNR). However, how to combine the MRS data in an optimized way from a multi-element coil array has been studied much less than MRI. A recently published method and routine combination methods have detrimental effects on SNR. We present herein a new method for optimal combination of multi-coilMRS data. METHODS: Based on an analytical solution for maximizing the SNR of the combined spectrum, a new method called "adaptively optimized combination (AOC)" of MRS data from phased array coils was developed in which the inversion of the full noise correlation matrix was incorporated into the coil weighting coefficients. Simulations were carried out to demonstrate the superior performance of the proposed AOC method in various noise scenarios. Validation experiments on human subjects were performed with different voxel locations and sizes on a 3T MRI scanner using an eight-element phased array head coil. RESULTS: Compared with a recently published method (i.e., weighting with the ratio of signal to the square of noise) and routine methods, our proposed AOC method adaptively and robustly produced significant SNR improvement in the combined spectra. CONCLUSION: The simulation and human experiments demonstrate that the proposed AOC method represents the theoretical optimal combination of MR spectroscopic data from multi-element coil arrays. Magn Reson Med 75:2235-2244, 2016.
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