Indications for adaptation to differently high vitamin C supplies in guinea pigs. 2. Development of hepatic amounts of microsomal protein and cytochromes (P-450, b5) after altered dosing.

Guinea pigs longlastingly (6-8 weeks) supplied with 680 mg/100 g vitamin in the food and for ten weeks thereafter exposed to: 5 mg/100 g: show no ability to maintain the amounts of hepatic microsomal cytochrome P-450 20 mg/100 g: show the typical symptom of an evolving adaptation by an overshoot of the amounts of hepatic microsomal cytochrome P-450.