Literature DB >> 26177256

Long non-coding RNA and chromatin remodeling.

Pei Han1,2, Ching-Pin Chang1,3,4.   

Abstract

Long noncoding RNAs (lncRNAs) are pivotal regulators of genome structure and gene expression. LncRNAs can directly interact with chromatin-modifying enzymes and nucleosome-remodeling factors to control chromatin structure and accessibility of genetic information. Moreover, lncRNA expression can be controlled by chromatin-remodeling factors, suggesting a feedback circuit of regulation. Here, we discuss the recent advances of lncRNA studies, focusing on the function and mechanism of lncRNA-chromatin interactions.

Keywords:  RNA therapeutics; chromatin modification; chromatin remodeling; human diseases; lncRNA promoter; lncRNA regulation; long non-coding RNA

Mesh：

Substances：

Year:  2015        PMID： 26177256      PMCID： PMC4829272          DOI： 10.1080/15476286.2015.1063770

Source DB:  PubMed          Journal:  RNA Biol        ISSN： 1547-6286            Impact factor:   4.652


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