Peng Xia1, Bin Li2, Tingting Geng3, Zhiping Deng4, Chengxue Dang4, Dongmin Chang4, Longli Kang5, Tianbo Jin6, Chao Chen7. 1. Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710061, China ; School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China. 2. Department of Oncology, First Affiliated Hospital, Xi'an Medical College Xi'an 710077, China. 3. National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China ; Department of endocrinology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710069, China. 4. Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710061, China. 5. Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University Xianyang, 712082, China ; Department of Genetics, Yale University School of Medicine New Haven, CT 06520 USA. 6. School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China ; Department of endocrinology, First Affiliated Hospital, Xi'an Jiaotong University Xi'an 710069, China. 7. School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
Abstract
AIMS AND BACKGROUND: Breast cancer is one of the most common neoplasms among women in many developing countries including China, and is the leading cause of female cancer-related deaths worldwide. METHODS: In the current study, we analyzed the relationship between 14 tag single-nucleotide polymorphisms (tSNPs) and breast cancer risk in the Han Chinese population including 185 breast cancer patients and 199 healthy women controls on the different types of breast cancer and menopausal status. RESULTS: Overall, we found rs2981579 in the FGFR2 gene, and rs2380205 were associated with breast cancer susceptibility. CONCLUSIONS: These findings indicate that FGFR2 was associated with breast cancer risk in the Han Chinese population, support the hypothesis that the applicability of a common susceptibility locus must be confirmed among genetically different populations.
AIMS AND BACKGROUND:Breast cancer is one of the most common neoplasms among women in many developing countries including China, and is the leading cause of female cancer-related deaths worldwide. METHODS: In the current study, we analyzed the relationship between 14 tag single-nucleotide polymorphisms (tSNPs) and breast cancer risk in the Han Chinese population including 185 breast cancerpatients and 199 healthy women controls on the different types of breast cancer and menopausal status. RESULTS: Overall, we found rs2981579 in the FGFR2 gene, and rs2380205 were associated with breast cancer susceptibility. CONCLUSIONS: These findings indicate that FGFR2 was associated with breast cancer risk in the Han Chinese population, support the hypothesis that the applicability of a common susceptibility locus must be confirmed among genetically different populations.
Entities:
Keywords:
FGFR2; Single nucleotide polymorphism (SNP); breast cancer; case-control studies
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