| Literature DB >> 16720584 |
Xavier Solé1, Elisabet Guinó, Joan Valls, Raquel Iniesta, Víctor Moreno.
Abstract
SUMMARY: A web-based application has been designed from a genetic epidemiology point of view to analyze association studies. Main capabilities include descriptive analysis, test for Hardy-Weinberg equilibrium and linkage disequilibrium. Analysis of association is based on linear or logistic regression according to the response variable (quantitative or binary disease status, respectively). Analysis of single SNPs: multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive), and analysis of interactions (gene-gene or gene-environment). Analysis of multiple SNPs: haplotype frequency estimation, analysis of association of haplotypes with the response, including analysis of interactions. AVAILABILITY: http://bioinfo.iconcologia.net/SNPstats. Source code for local installation is available under GNU license.Mesh：
Substances：
Year: 2006 PMID： 16720584 DOI： 10.1093/bioinformatics/btl268
Source DB: PubMed Journal: Bioinformatics ISSN： 1367-4803 Impact factor: 6.937